Connexin 43 Loss Triggers Cell Cycle Entry and Invasion in Non-Neoplastic Breast Epithelium: A Role for Noncanonical Wnt Signaling

Connexin 43 Loss Triggers Cell Cycle Entry and Invasion in Non-Neoplastic Breast Epithelium: A Role for Noncanonical Wnt Signaling

(1) Background: The expression of connexin 43 (Cx43) is disrupted in breast cancer, and re-expression of this protein in human breast cancer cell lines leads to decreased proliferation and invasiveness, suggesting a tumor suppressive role. This study aims to investigate the role of Cx43 in prolifera...

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Bibliographic Details
Main Authors: Sabreen Fostok, Mirvat El-Sibai, Dana Bazzoun, Sophie Lelièvre, Rabih Talhouk
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
mammary gland
mammary epithelium
breast cancer
gap junctions
connexin 43
Wnt pathways
proliferation
motility
invasion
microenvironment
Online Access:http://www.mdpi.com/2072-6694/11/3/339

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