Water Is an Active Element: A Randomized Double-Blind Controlled Clinical Trial Comparing Cutaneous Lipidomics in Consumers Drinking Two Different Bicarbonate-Calcic Waters (Medium-Mineral vs. Oligo-Mineral)
Despite the well-known cutaneous beneficial effect of thermal water on the skin, no data exist regarding the potential biological effect of orally consumed water on healthy skin. Thus, in this single-center, double-blind, randomized controlled clinical trial conducted on age and menstrual cycle timi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/4/1036 |
| _version_ | 1827745733533499392 |
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| author | Giovanni Damiani Ilaria Controne Hilmi Al-Shakhshir Paolo D. M. Pigatto |
| author_facet | Giovanni Damiani Ilaria Controne Hilmi Al-Shakhshir Paolo D. M. Pigatto |
| author_sort | Giovanni Damiani |
| collection | DOAJ |
| description | Despite the well-known cutaneous beneficial effect of thermal water on the skin, no data exist regarding the potential biological effect of orally consumed water on healthy skin. Thus, in this single-center, double-blind, randomized controlled clinical trial conducted on age and menstrual cycle timing-matched healthy female volunteers (24 + 24) consuming water A (oligo-mineral) or water B (medium-mineral) for 1 month (T1), the cutaneous lipidomics were compared. Interestingly, only water A consumers had a statistically significant (<i>p</i> < 0.001) change in cutaneous lipidomics, with 66 lipids different (8 decreased and 58 increased). The cutaneous lipidomics of consumers of water A vs. water B were statistically different (<i>p</i> < 0.05). Twenty cutaneous lipids were necessary to predict the water type previously consumed (AUC ~70). Our study suggests that drinking oligo-mineral water may change skin biology and may influence the cutaneous barrier, so future dermatological clinical trials should also account for the water type consumed to avoid potential confounders. |
| first_indexed | 2024-03-11T05:12:40Z |
| format | Article |
| id | doaj.art-08c7aa6a983e47798171520833ae77f8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T05:12:40Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-08c7aa6a983e47798171520833ae77f82023-11-17T18:25:37ZengMDPI AGBiomedicines2227-90592023-03-01114103610.3390/biomedicines11041036Water Is an Active Element: A Randomized Double-Blind Controlled Clinical Trial Comparing Cutaneous Lipidomics in Consumers Drinking Two Different Bicarbonate-Calcic Waters (Medium-Mineral vs. Oligo-Mineral)Giovanni Damiani0Ilaria Controne1Hilmi Al-Shakhshir2Paolo D. M. Pigatto3Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, ItalyClinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, ItalyDepartment of Dermatology, Case Western Reserve University, Cleveland, OH 44106, USAClinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, ItalyDespite the well-known cutaneous beneficial effect of thermal water on the skin, no data exist regarding the potential biological effect of orally consumed water on healthy skin. Thus, in this single-center, double-blind, randomized controlled clinical trial conducted on age and menstrual cycle timing-matched healthy female volunteers (24 + 24) consuming water A (oligo-mineral) or water B (medium-mineral) for 1 month (T1), the cutaneous lipidomics were compared. Interestingly, only water A consumers had a statistically significant (<i>p</i> < 0.001) change in cutaneous lipidomics, with 66 lipids different (8 decreased and 58 increased). The cutaneous lipidomics of consumers of water A vs. water B were statistically different (<i>p</i> < 0.05). Twenty cutaneous lipids were necessary to predict the water type previously consumed (AUC ~70). Our study suggests that drinking oligo-mineral water may change skin biology and may influence the cutaneous barrier, so future dermatological clinical trials should also account for the water type consumed to avoid potential confounders.https://www.mdpi.com/2227-9059/11/4/1036oligo-mineral watermedium-mineral waterwatersskinprecision medicinelipidomics |
| spellingShingle | Giovanni Damiani Ilaria Controne Hilmi Al-Shakhshir Paolo D. M. Pigatto Water Is an Active Element: A Randomized Double-Blind Controlled Clinical Trial Comparing Cutaneous Lipidomics in Consumers Drinking Two Different Bicarbonate-Calcic Waters (Medium-Mineral vs. Oligo-Mineral) Biomedicines oligo-mineral water medium-mineral water waters skin precision medicine lipidomics |
| title | Water Is an Active Element: A Randomized Double-Blind Controlled Clinical Trial Comparing Cutaneous Lipidomics in Consumers Drinking Two Different Bicarbonate-Calcic Waters (Medium-Mineral vs. Oligo-Mineral) |
| title_full | Water Is an Active Element: A Randomized Double-Blind Controlled Clinical Trial Comparing Cutaneous Lipidomics in Consumers Drinking Two Different Bicarbonate-Calcic Waters (Medium-Mineral vs. Oligo-Mineral) |
| title_fullStr | Water Is an Active Element: A Randomized Double-Blind Controlled Clinical Trial Comparing Cutaneous Lipidomics in Consumers Drinking Two Different Bicarbonate-Calcic Waters (Medium-Mineral vs. Oligo-Mineral) |
| title_full_unstemmed | Water Is an Active Element: A Randomized Double-Blind Controlled Clinical Trial Comparing Cutaneous Lipidomics in Consumers Drinking Two Different Bicarbonate-Calcic Waters (Medium-Mineral vs. Oligo-Mineral) |
| title_short | Water Is an Active Element: A Randomized Double-Blind Controlled Clinical Trial Comparing Cutaneous Lipidomics in Consumers Drinking Two Different Bicarbonate-Calcic Waters (Medium-Mineral vs. Oligo-Mineral) |
| title_sort | water is an active element a randomized double blind controlled clinical trial comparing cutaneous lipidomics in consumers drinking two different bicarbonate calcic waters medium mineral vs oligo mineral |
| topic | oligo-mineral water medium-mineral water waters skin precision medicine lipidomics |
| url | https://www.mdpi.com/2227-9059/11/4/1036 |
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