New anticoagulants for the prevention and treatment of venous thromboembolism
Simon J McRae, Jeffrey S GinsbergDepartment of Medicine, McMaster University, Hamilton, ON, CanadaAbstract: Anticoagulant therapy is effective at preventing the development of venous thromboembolism in high-risk patients, and reduces morbidity and mortality in individuals with established thromboemb...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2005-04-01
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| Series: | Vascular Health and Risk Management |
| Online Access: | https://www.dovepress.com/new-anticoagulants-for-the-prevention-and-treatment-of-venous-thromboe-peer-reviewed-article-VHRM |
| _version_ | 1818238560592986112 |
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| author | Simon J McRae Jeffrey S Ginsberg |
| author_facet | Simon J McRae Jeffrey S Ginsberg |
| author_sort | Simon J McRae |
| collection | DOAJ |
| description | Simon J McRae, Jeffrey S GinsbergDepartment of Medicine, McMaster University, Hamilton, ON, CanadaAbstract: Anticoagulant therapy is effective at preventing the development of venous thromboembolism in high-risk patients, and reduces morbidity and mortality in individuals with established thromboembolic disease. Vitamin K antagonists and heparins are currently the most commonly used anticoagulant drugs, but they have practical limitations. Therefore, new antithrombotic agents with predictable dose-responses (thereby decreasing the need for monitoring without compromising efficacy or safety), ideally available in an oral formulation and with a rapidly reversible anticoagulant effect, are needed. New drugs fulfilling some of the above criteria have been developed and have proven to be effective agents for the treatment and prevention of venous thromboembolism.Keywords: venous thromboembolism, anticoagulants, antithrombotic |
| first_indexed | 2024-12-12T12:43:36Z |
| format | Article |
| id | doaj.art-08c7ba76d1334ca58dfd6bdba9ff6f30 |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-12T12:43:36Z |
| publishDate | 2005-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-08c7ba76d1334ca58dfd6bdba9ff6f302022-12-22T00:24:10ZengDove Medical PressVascular Health and Risk Management1178-20482005-04-01Volume 141531364New anticoagulants for the prevention and treatment of venous thromboembolismSimon J McRaeJeffrey S GinsbergSimon J McRae, Jeffrey S GinsbergDepartment of Medicine, McMaster University, Hamilton, ON, CanadaAbstract: Anticoagulant therapy is effective at preventing the development of venous thromboembolism in high-risk patients, and reduces morbidity and mortality in individuals with established thromboembolic disease. Vitamin K antagonists and heparins are currently the most commonly used anticoagulant drugs, but they have practical limitations. Therefore, new antithrombotic agents with predictable dose-responses (thereby decreasing the need for monitoring without compromising efficacy or safety), ideally available in an oral formulation and with a rapidly reversible anticoagulant effect, are needed. New drugs fulfilling some of the above criteria have been developed and have proven to be effective agents for the treatment and prevention of venous thromboembolism.Keywords: venous thromboembolism, anticoagulants, antithrombotichttps://www.dovepress.com/new-anticoagulants-for-the-prevention-and-treatment-of-venous-thromboe-peer-reviewed-article-VHRM |
| spellingShingle | Simon J McRae Jeffrey S Ginsberg New anticoagulants for the prevention and treatment of venous thromboembolism Vascular Health and Risk Management |
| title | New anticoagulants for the prevention and treatment of venous thromboembolism |
| title_full | New anticoagulants for the prevention and treatment of venous thromboembolism |
| title_fullStr | New anticoagulants for the prevention and treatment of venous thromboembolism |
| title_full_unstemmed | New anticoagulants for the prevention and treatment of venous thromboembolism |
| title_short | New anticoagulants for the prevention and treatment of venous thromboembolism |
| title_sort | new anticoagulants for the prevention and treatment of venous thromboembolism |
| url | https://www.dovepress.com/new-anticoagulants-for-the-prevention-and-treatment-of-venous-thromboe-peer-reviewed-article-VHRM |
| work_keys_str_mv | AT simonjmcrae newanticoagulantsforthepreventionandtreatmentofvenousthromboembolism AT jeffreysginsberg newanticoagulantsforthepreventionandtreatmentofvenousthromboembolism |