Evaluation of Predictors of Biochemical Recurrence in Prostate Cancer Patients, as Detected by <sup>68</sup>Ga-PSMA PET/CT
Objectives: To explore the existence of new predictors of the <sup>68</sup>Ga-Prostate-Specific Membrane Antigen (PSMA) PET/CT detection rate at biochemical recurrence (BCR) and to determine the detection rate of <sup>68</sup>Ga-PSMA PET/CT dependent of prostate-specific anti...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/1/195 |
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| author | Mads T. Christensen Mads R. Jochumsen Søren Klingenberg Karina D. Sørensen Michael Borre Kirsten Bouchelouche |
| author_facet | Mads T. Christensen Mads R. Jochumsen Søren Klingenberg Karina D. Sørensen Michael Borre Kirsten Bouchelouche |
| author_sort | Mads T. Christensen |
| collection | DOAJ |
| description | Objectives: To explore the existence of new predictors of the <sup>68</sup>Ga-Prostate-Specific Membrane Antigen (PSMA) PET/CT detection rate at biochemical recurrence (BCR) and to determine the detection rate of <sup>68</sup>Ga-PSMA PET/CT dependent of prostate-specific antigen (PSA) levels. Materials and methods: In total, 189 PCa patients scanned with <sup>68</sup>Ga-PSMA PET/CT for detection of BCR after curatively intended treatment with either radical prostatectomy (<i>n</i> = 153) or radiotherapy (<i>n</i> = 36) were included. Clinicopathological information at the time of diagnosis (PSA, clinical tumor-stage, International Society of Urological Pathology Grade Group and whether <sup>68</sup>Ga-PSMA PET/CT was used for primary staging), treatment (RT/RP and histopathology of the prostatectomies), and pre-PET PSA were collected from medical records. Results: Of the 189 <sup>68</sup>Ga-PSMA PET/CT scans, 103 (54.5%) were positive for BCR of PCa. No significant coherency was observed between detection rate and any clinicopathological variables at diagnosis. Detection rates significantly increased with rising PSA: <0.5 ng/mL = 28%, 0.5 ≤ 1 ng/mL = 39%, 1 ≤ 2 ng/mL = 64%, 2 ≤ 5 ng/mL = 87.5% and ≥5 ng/mL = 97%. Conclusions: The detection rate of PCa recurrence was strongly dependent of pre-PET PSA levels. None of the additional clinical variables acquired during primary staging, prostatectomy pathology reports, nor primary staging imaging modality affected the detection rate. |
| first_indexed | 2024-03-10T01:37:05Z |
| format | Article |
| id | doaj.art-08ca28f580354418ba114677a6e21a70 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T01:37:05Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-08ca28f580354418ba114677a6e21a702023-11-23T13:29:55ZengMDPI AGDiagnostics2075-44182022-01-0112119510.3390/diagnostics12010195Evaluation of Predictors of Biochemical Recurrence in Prostate Cancer Patients, as Detected by <sup>68</sup>Ga-PSMA PET/CTMads T. Christensen0Mads R. Jochumsen1Søren Klingenberg2Karina D. Sørensen3Michael Borre4Kirsten Bouchelouche5Department of Nuclear Medicine, PET-Centre, Aarhus University Hospital, 8200 Aarhus, DenmarkDepartment of Nuclear Medicine, PET-Centre, Aarhus University Hospital, 8200 Aarhus, DenmarkDepartment of Nuclear Medicine, PET-Centre, Aarhus University Hospital, 8200 Aarhus, DenmarkDepartment of Clinical Medicine, Aarhus University, 8000 Aarhus, DenmarkDepartment of Clinical Medicine, Aarhus University, 8000 Aarhus, DenmarkDepartment of Nuclear Medicine, PET-Centre, Aarhus University Hospital, 8200 Aarhus, DenmarkObjectives: To explore the existence of new predictors of the <sup>68</sup>Ga-Prostate-Specific Membrane Antigen (PSMA) PET/CT detection rate at biochemical recurrence (BCR) and to determine the detection rate of <sup>68</sup>Ga-PSMA PET/CT dependent of prostate-specific antigen (PSA) levels. Materials and methods: In total, 189 PCa patients scanned with <sup>68</sup>Ga-PSMA PET/CT for detection of BCR after curatively intended treatment with either radical prostatectomy (<i>n</i> = 153) or radiotherapy (<i>n</i> = 36) were included. Clinicopathological information at the time of diagnosis (PSA, clinical tumor-stage, International Society of Urological Pathology Grade Group and whether <sup>68</sup>Ga-PSMA PET/CT was used for primary staging), treatment (RT/RP and histopathology of the prostatectomies), and pre-PET PSA were collected from medical records. Results: Of the 189 <sup>68</sup>Ga-PSMA PET/CT scans, 103 (54.5%) were positive for BCR of PCa. No significant coherency was observed between detection rate and any clinicopathological variables at diagnosis. Detection rates significantly increased with rising PSA: <0.5 ng/mL = 28%, 0.5 ≤ 1 ng/mL = 39%, 1 ≤ 2 ng/mL = 64%, 2 ≤ 5 ng/mL = 87.5% and ≥5 ng/mL = 97%. Conclusions: The detection rate of PCa recurrence was strongly dependent of pre-PET PSA levels. None of the additional clinical variables acquired during primary staging, prostatectomy pathology reports, nor primary staging imaging modality affected the detection rate.https://www.mdpi.com/2075-4418/12/1/195prostate cancer<sup>68</sup>Ga-Prostate-Specific Membrane Antigen PET/CT<sup>68</sup>Ga-PSMAbiochemical recurrencedetection ratepredictors |
| spellingShingle | Mads T. Christensen Mads R. Jochumsen Søren Klingenberg Karina D. Sørensen Michael Borre Kirsten Bouchelouche Evaluation of Predictors of Biochemical Recurrence in Prostate Cancer Patients, as Detected by <sup>68</sup>Ga-PSMA PET/CT Diagnostics prostate cancer <sup>68</sup>Ga-Prostate-Specific Membrane Antigen PET/CT <sup>68</sup>Ga-PSMA biochemical recurrence detection rate predictors |
| title | Evaluation of Predictors of Biochemical Recurrence in Prostate Cancer Patients, as Detected by <sup>68</sup>Ga-PSMA PET/CT |
| title_full | Evaluation of Predictors of Biochemical Recurrence in Prostate Cancer Patients, as Detected by <sup>68</sup>Ga-PSMA PET/CT |
| title_fullStr | Evaluation of Predictors of Biochemical Recurrence in Prostate Cancer Patients, as Detected by <sup>68</sup>Ga-PSMA PET/CT |
| title_full_unstemmed | Evaluation of Predictors of Biochemical Recurrence in Prostate Cancer Patients, as Detected by <sup>68</sup>Ga-PSMA PET/CT |
| title_short | Evaluation of Predictors of Biochemical Recurrence in Prostate Cancer Patients, as Detected by <sup>68</sup>Ga-PSMA PET/CT |
| title_sort | evaluation of predictors of biochemical recurrence in prostate cancer patients as detected by sup 68 sup ga psma pet ct |
| topic | prostate cancer <sup>68</sup>Ga-Prostate-Specific Membrane Antigen PET/CT <sup>68</sup>Ga-PSMA biochemical recurrence detection rate predictors |
| url | https://www.mdpi.com/2075-4418/12/1/195 |
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