Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation
Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem ce...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-03-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4923/11/3/117 |
| _version_ | 1828359193383403520 |
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| author | Werner Götz Edda Tobiasch Steffen Witzleben Margit Schulze |
| author_facet | Werner Götz Edda Tobiasch Steffen Witzleben Margit Schulze |
| author_sort | Werner Götz |
| collection | DOAJ |
| description | Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation. |
| first_indexed | 2024-04-14T03:38:18Z |
| format | Article |
| id | doaj.art-08ca296244054255a13067f5ca6beed1 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-14T03:38:18Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-08ca296244054255a13067f5ca6beed12022-12-22T02:14:37ZengMDPI AGPharmaceutics1999-49232019-03-0111311710.3390/pharmaceutics11030117pharmaceutics11030117Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue FormationWerner Götz0Edda Tobiasch1Steffen Witzleben2Margit Schulze3Department of Orthodontics, Oral Biology Laboratory, School of Dentistry, Rheinische Wilhelms University of Bonn, Welschnonnenstr. 17, D-53111 Bonn, GermanyDepartment of Natural Sciences, Bonn-Rhine-Sieg University of Applied Sciences, D-53359 Rheinbach, GermanyDepartment of Natural Sciences, Bonn-Rhine-Sieg University of Applied Sciences, D-53359 Rheinbach, GermanyDepartment of Natural Sciences, Bonn-Rhine-Sieg University of Applied Sciences, D-53359 Rheinbach, GermanyBioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation.http://www.mdpi.com/1999-4923/11/3/117alveolar bonebiomineralizationosteoblastosteogenesisscaffoldsiliconsilicatesstem cellstissue engineering |
| spellingShingle | Werner Götz Edda Tobiasch Steffen Witzleben Margit Schulze Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation Pharmaceutics alveolar bone biomineralization osteoblast osteogenesis scaffold silicon silicates stem cells tissue engineering |
| title | Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation |
| title_full | Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation |
| title_fullStr | Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation |
| title_full_unstemmed | Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation |
| title_short | Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation |
| title_sort | effects of silicon compounds on biomineralization osteogenesis and hard tissue formation |
| topic | alveolar bone biomineralization osteoblast osteogenesis scaffold silicon silicates stem cells tissue engineering |
| url | http://www.mdpi.com/1999-4923/11/3/117 |
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