Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil
Hemoglobinopathies are hereditary disorders of the hemoglobin molecule with a high prevalence worldwide. Brazil has a prevalence of 0.1 to 0.3% of newborns with sickle cell anemia and 20.0 to 25.0% of heterozygous alpha2 thalassemia among African Brazilians. In the present study, we investigated the...
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| Format: | Article |
| Language: | English |
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Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
2005-01-01
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| Series: | Cadernos de Saúde Pública |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2005000100032 |
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| author | Adorno Elisângela Vitória Couto Fábio David Moura Neto José Pereira de Menezes Joelma Figueiredo Rêgo Marco Reis Mitermayer Galvão dos Gonçalves Marilda Souza |
| author_facet | Adorno Elisângela Vitória Couto Fábio David Moura Neto José Pereira de Menezes Joelma Figueiredo Rêgo Marco Reis Mitermayer Galvão dos Gonçalves Marilda Souza |
| author_sort | Adorno Elisângela Vitória |
| collection | DOAJ |
| description | Hemoglobinopathies are hereditary disorders of the hemoglobin molecule with a high prevalence worldwide. Brazil has a prevalence of 0.1 to 0.3% of newborns with sickle cell anemia and 20.0 to 25.0% of heterozygous alpha2 thalassemia among African Brazilians. In the present study, we investigated the presence of variant hemoglobins and alpha2(3.7 Kb) and alpha2(4.2 Kb) thalassemia in newborns from Salvador, Bahia, Brazil. Samples of umbilical cord blood from a total of 590 newborns were analyzed, of which 57 (9.8%) were FAS; 36 (6.5%) FAC; one (0.2%) SF; and five (0.9%) FSC. One hundred fourteen (22.2%) newborns had alpha2(3.7 Kb) thalassemia, of whom 101 (19.7%) were heterozygous and 13 (2.5%) homozygous, showing statistical significance for hematological data between newborns with normal alpha genes and alpha2(3.7 Kb) thalassemia carriers. The alpha2(4.2 Kb) thalassemia was not found. Frequencies found in the present study confirm that hemoglobinopathies are a public health problem in Brazil, emphasizing the need for neonatal screening and genetic counseling programs. |
| first_indexed | 2024-12-20T12:02:06Z |
| format | Article |
| id | doaj.art-08cb1aee4d1945bb8241252e32212b83 |
| institution | Directory Open Access Journal |
| issn | 0102-311X 1678-4464 |
| language | English |
| last_indexed | 2024-12-20T12:02:06Z |
| publishDate | 2005-01-01 |
| publisher | Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz |
| record_format | Article |
| series | Cadernos de Saúde Pública |
| spelling | doaj.art-08cb1aee4d1945bb8241252e32212b832022-12-21T19:41:30ZengEscola Nacional de Saúde Pública, Fundação Oswaldo CruzCadernos de Saúde Pública0102-311X1678-44642005-01-01211292298Hemoglobinopathies in newborns from Salvador, Bahia, Northeast BrazilAdorno Elisângela VitóriaCouto Fábio DavidMoura Neto José Pereira deMenezes Joelma FigueiredoRêgo MarcoReis Mitermayer Galvão dosGonçalves Marilda SouzaHemoglobinopathies are hereditary disorders of the hemoglobin molecule with a high prevalence worldwide. Brazil has a prevalence of 0.1 to 0.3% of newborns with sickle cell anemia and 20.0 to 25.0% of heterozygous alpha2 thalassemia among African Brazilians. In the present study, we investigated the presence of variant hemoglobins and alpha2(3.7 Kb) and alpha2(4.2 Kb) thalassemia in newborns from Salvador, Bahia, Brazil. Samples of umbilical cord blood from a total of 590 newborns were analyzed, of which 57 (9.8%) were FAS; 36 (6.5%) FAC; one (0.2%) SF; and five (0.9%) FSC. One hundred fourteen (22.2%) newborns had alpha2(3.7 Kb) thalassemia, of whom 101 (19.7%) were heterozygous and 13 (2.5%) homozygous, showing statistical significance for hematological data between newborns with normal alpha genes and alpha2(3.7 Kb) thalassemia carriers. The alpha2(4.2 Kb) thalassemia was not found. Frequencies found in the present study confirm that hemoglobinopathies are a public health problem in Brazil, emphasizing the need for neonatal screening and genetic counseling programs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2005000100032HemoglobinopathiesSickle Cell AnemiaThalassemiaNewborn Infant |
| spellingShingle | Adorno Elisângela Vitória Couto Fábio David Moura Neto José Pereira de Menezes Joelma Figueiredo Rêgo Marco Reis Mitermayer Galvão dos Gonçalves Marilda Souza Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil Cadernos de Saúde Pública Hemoglobinopathies Sickle Cell Anemia Thalassemia Newborn Infant |
| title | Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil |
| title_full | Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil |
| title_fullStr | Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil |
| title_full_unstemmed | Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil |
| title_short | Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil |
| title_sort | hemoglobinopathies in newborns from salvador bahia northeast brazil |
| topic | Hemoglobinopathies Sickle Cell Anemia Thalassemia Newborn Infant |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2005000100032 |
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