YAP1 is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Pancreatic Cancer
Yes-associated protein-1 (YAP1) is an important effector of the Hippo pathway and has crosstalk with other cancer signaling pathways. It induces an immunosuppressive tumor microenvironment by activating pathways in several cellular components. However, the mechanisms by which it drives immune infilt...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.625731/full |
| _version_ | 1818734332352659456 |
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| author | Kai Sun Xue-de Zhang Xiao-yang Liu Pei Lu |
| author_facet | Kai Sun Xue-de Zhang Xiao-yang Liu Pei Lu |
| author_sort | Kai Sun |
| collection | DOAJ |
| description | Yes-associated protein-1 (YAP1) is an important effector of the Hippo pathway and has crosstalk with other cancer signaling pathways. It induces an immunosuppressive tumor microenvironment by activating pathways in several cellular components. However, the mechanisms by which it drives immune infiltration in pancreatic cancer remain poorly understood. We analyzed the expression of YAP1 as well as its prognostic value and correlations with immune infiltrates in various cancers, with a focus on pancreatic cancer. In particular, using the Oncomine database and Gene Expression Profiling Interactive Analysis (GEPIA) database, we found that YAP1 is differentially expressed between tumor tissues and control tissues in a number of cancers and in particular, is elevated in pancreatic cancer. Using the Kaplan–Meier plotter, GEPIA, and Long-term Outcome and Gene Expression Profiling database of pan-cancers (LOGpc), we further established the prognostic value of YAP1. We found that YAP1 expression was significantly related to outcomes in multiple types of cancer based on data from The Cancer Genome Atlas, particularly in pancreatic cancer. Correlations between YAP1 and immune cell infiltration and immune cell marker expression were examined using Tumor Immune Estimation Resource and GEPIA. High expression levels of YAP1 were significantly associated with a variety of immune markers and immune cell subsets in pancreatic cancer. These results suggest that YAP1 is correlated with patient outcomes and tumor immune cell infiltration in multiple cancer types and is a valuable prognostic biomarker in pancreatic cancer. |
| first_indexed | 2024-12-18T00:03:41Z |
| format | Article |
| id | doaj.art-08cc79967aa04812a8957b6ee1006fd6 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-18T00:03:41Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-08cc79967aa04812a8957b6ee1006fd62022-12-21T21:27:53ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-06-01810.3389/fmolb.2021.625731625731YAP1 is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Pancreatic CancerKai Sun0Xue-de Zhang1Xiao-yang Liu2Pei Lu3Department of Oncology, Liuzhou People’s Hospital, Liuzhou, ChinaDepartment of Hematology and Oncology, Beilun District People’s Hospital, Ningbo, ChinaDepartment of General Surgery, People's Hospital of Gansu Province, Lanzhou, ChinaDepartment of Oncology, Liuzhou People’s Hospital, Liuzhou, ChinaYes-associated protein-1 (YAP1) is an important effector of the Hippo pathway and has crosstalk with other cancer signaling pathways. It induces an immunosuppressive tumor microenvironment by activating pathways in several cellular components. However, the mechanisms by which it drives immune infiltration in pancreatic cancer remain poorly understood. We analyzed the expression of YAP1 as well as its prognostic value and correlations with immune infiltrates in various cancers, with a focus on pancreatic cancer. In particular, using the Oncomine database and Gene Expression Profiling Interactive Analysis (GEPIA) database, we found that YAP1 is differentially expressed between tumor tissues and control tissues in a number of cancers and in particular, is elevated in pancreatic cancer. Using the Kaplan–Meier plotter, GEPIA, and Long-term Outcome and Gene Expression Profiling database of pan-cancers (LOGpc), we further established the prognostic value of YAP1. We found that YAP1 expression was significantly related to outcomes in multiple types of cancer based on data from The Cancer Genome Atlas, particularly in pancreatic cancer. Correlations between YAP1 and immune cell infiltration and immune cell marker expression were examined using Tumor Immune Estimation Resource and GEPIA. High expression levels of YAP1 were significantly associated with a variety of immune markers and immune cell subsets in pancreatic cancer. These results suggest that YAP1 is correlated with patient outcomes and tumor immune cell infiltration in multiple cancer types and is a valuable prognostic biomarker in pancreatic cancer.https://www.frontiersin.org/articles/10.3389/fmolb.2021.625731/fullpancreatic cancerHippo pathwayprognosisYes-associated protein-1tumor infiltration |
| spellingShingle | Kai Sun Xue-de Zhang Xiao-yang Liu Pei Lu YAP1 is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Pancreatic Cancer Frontiers in Molecular Biosciences pancreatic cancer Hippo pathway prognosis Yes-associated protein-1 tumor infiltration |
| title | YAP1 is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Pancreatic Cancer |
| title_full | YAP1 is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Pancreatic Cancer |
| title_fullStr | YAP1 is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Pancreatic Cancer |
| title_full_unstemmed | YAP1 is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Pancreatic Cancer |
| title_short | YAP1 is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Pancreatic Cancer |
| title_sort | yap1 is a prognostic biomarker and correlated with immune cell infiltration in pancreatic cancer |
| topic | pancreatic cancer Hippo pathway prognosis Yes-associated protein-1 tumor infiltration |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.625731/full |
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