Direct-Acting Antiviral Drugs Reduce Fibromyalgia Symptoms in Patients with Chronic Hepatitis C
Background Fibromyalgia (FM) is a complex disorder characterized by chronic widespread pain and significant patient burden. Patients with chronic hepatitis C are reportedly predisposed to the development of FM. Direct-acting antiviral drugs (DAA) achieved a remarkable therapeutic efficacy in CHC pat...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/18/5327 |
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| author | Kuo-Tung Tang Ching-Chun Lin Yi-Hsing Chen Tsai-Ling Liao Der-Yuan Chen Sheng-Shun Yang Chia-Chang Chen |
| author_facet | Kuo-Tung Tang Ching-Chun Lin Yi-Hsing Chen Tsai-Ling Liao Der-Yuan Chen Sheng-Shun Yang Chia-Chang Chen |
| author_sort | Kuo-Tung Tang |
| collection | DOAJ |
| description | Background Fibromyalgia (FM) is a complex disorder characterized by chronic widespread pain and significant patient burden. Patients with chronic hepatitis C are reportedly predisposed to the development of FM. Direct-acting antiviral drugs (DAA) achieved a remarkable therapeutic efficacy in CHC patients. We therefore investigated the impact of DAA on FM symptoms in CHC patients. Methods We enrolled consecutive CHC patients who received DAA. FM symptoms were evaluated based on the 2016 American College of Rheumatology (ACR) fibromyalgia scale at baseline and 12 and 24 weeks after cessation of DAA therapy. Logistic regression was performed to determine the influence of HCV on FM at baseline. We also recruited individuals who underwent a health checkup examination as the control group, and calculated the standardized prevalence ratio of FM in CHC patients. Comparisons of fibromyalgia in different time points were undertaken using the Wilcoxon signed-rank test. Results A total of 33 CHC patients (15 males and 18 females) and 402 controls were recruited. All CHC patients achieved sustained virological response. Two (6%) patients and two (0.5%) controls fulfilled the diagnostic criteria for FM, and the standardized prevalence ratio was 23.9 in CHC patients. Logistic regression also showed increased odds for FM in CHC patients after adjusting for age and sex (OR: 14.4; 95%CI: 1.6, 128.0). In addition, their fibromyalgianess scale decreased at 12 and 24 weeks after DAA therapy. In conclusion, CHC patients were more likely to develop FM. Implementation of DAA therapy might improve FM symptoms in these patients. |
| first_indexed | 2024-03-09T23:36:39Z |
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| id | doaj.art-08cd43426f5847c49bf11a8e845f9f6d |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:36:39Z |
| publishDate | 2022-09-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-08cd43426f5847c49bf11a8e845f9f6d2023-11-23T16:58:50ZengMDPI AGJournal of Clinical Medicine2077-03832022-09-011118532710.3390/jcm11185327Direct-Acting Antiviral Drugs Reduce Fibromyalgia Symptoms in Patients with Chronic Hepatitis CKuo-Tung Tang0Ching-Chun Lin1Yi-Hsing Chen2Tsai-Ling Liao3Der-Yuan Chen4Sheng-Shun Yang5Chia-Chang Chen6Division of Allergy, Immunology, and Rheumatology, Taichung Veterans General Hospital, Taichung 407, TaiwanDepartment of Family Medicine, China Medical University Hospital, Taichung 404, TaiwanDivision of Allergy, Immunology, and Rheumatology, Taichung Veterans General Hospital, Taichung 407, TaiwanPh.D. Program in Translational Medicine and Rong Hsing Research Center for Translational Medicine, College of Life Sciences, National Chung Hsing University, Taichung 402, TaiwanPh.D. Program in Translational Medicine and Rong Hsing Research Center for Translational Medicine, College of Life Sciences, National Chung Hsing University, Taichung 402, TaiwanFaculty of Medicine, National Yang Ming Chiao Tung University, Taipei 112, TaiwanDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, TaiwanBackground Fibromyalgia (FM) is a complex disorder characterized by chronic widespread pain and significant patient burden. Patients with chronic hepatitis C are reportedly predisposed to the development of FM. Direct-acting antiviral drugs (DAA) achieved a remarkable therapeutic efficacy in CHC patients. We therefore investigated the impact of DAA on FM symptoms in CHC patients. Methods We enrolled consecutive CHC patients who received DAA. FM symptoms were evaluated based on the 2016 American College of Rheumatology (ACR) fibromyalgia scale at baseline and 12 and 24 weeks after cessation of DAA therapy. Logistic regression was performed to determine the influence of HCV on FM at baseline. We also recruited individuals who underwent a health checkup examination as the control group, and calculated the standardized prevalence ratio of FM in CHC patients. Comparisons of fibromyalgia in different time points were undertaken using the Wilcoxon signed-rank test. Results A total of 33 CHC patients (15 males and 18 females) and 402 controls were recruited. All CHC patients achieved sustained virological response. Two (6%) patients and two (0.5%) controls fulfilled the diagnostic criteria for FM, and the standardized prevalence ratio was 23.9 in CHC patients. Logistic regression also showed increased odds for FM in CHC patients after adjusting for age and sex (OR: 14.4; 95%CI: 1.6, 128.0). In addition, their fibromyalgianess scale decreased at 12 and 24 weeks after DAA therapy. In conclusion, CHC patients were more likely to develop FM. Implementation of DAA therapy might improve FM symptoms in these patients.https://www.mdpi.com/2077-0383/11/18/5327direct-acting antiviral drugsfibromyalgiahepatitis Cpain |
| spellingShingle | Kuo-Tung Tang Ching-Chun Lin Yi-Hsing Chen Tsai-Ling Liao Der-Yuan Chen Sheng-Shun Yang Chia-Chang Chen Direct-Acting Antiviral Drugs Reduce Fibromyalgia Symptoms in Patients with Chronic Hepatitis C Journal of Clinical Medicine direct-acting antiviral drugs fibromyalgia hepatitis C pain |
| title | Direct-Acting Antiviral Drugs Reduce Fibromyalgia Symptoms in Patients with Chronic Hepatitis C |
| title_full | Direct-Acting Antiviral Drugs Reduce Fibromyalgia Symptoms in Patients with Chronic Hepatitis C |
| title_fullStr | Direct-Acting Antiviral Drugs Reduce Fibromyalgia Symptoms in Patients with Chronic Hepatitis C |
| title_full_unstemmed | Direct-Acting Antiviral Drugs Reduce Fibromyalgia Symptoms in Patients with Chronic Hepatitis C |
| title_short | Direct-Acting Antiviral Drugs Reduce Fibromyalgia Symptoms in Patients with Chronic Hepatitis C |
| title_sort | direct acting antiviral drugs reduce fibromyalgia symptoms in patients with chronic hepatitis c |
| topic | direct-acting antiviral drugs fibromyalgia hepatitis C pain |
| url | https://www.mdpi.com/2077-0383/11/18/5327 |
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