Associations between omega-3 polyunsaturated fatty acids supplementation and surgical prognosis in patients with gastrointestinal cancer: A systematic review and meta-analysis
Background: Surgical resection remains the primary treatment for gastrointestinal (GI) cancer, omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to improve the prognosis of patients undergoing gastrointestinal tumor surgery. This meta-analysis aims to explore the efficacy of n-3 PUF...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Food Chemistry: Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666566222000272 |
| _version_ | 1828748010768564224 |
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| author | Shuai Lu Zhenpeng Yang Huazhen Tang Xibo Sun Bing Wang Jinxiu Qu Yuying Wang Penghui Yang Benqiang Rao |
| author_facet | Shuai Lu Zhenpeng Yang Huazhen Tang Xibo Sun Bing Wang Jinxiu Qu Yuying Wang Penghui Yang Benqiang Rao |
| author_sort | Shuai Lu |
| collection | DOAJ |
| description | Background: Surgical resection remains the primary treatment for gastrointestinal (GI) cancer, omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to improve the prognosis of patients undergoing gastrointestinal tumor surgery. This meta-analysis aims to explore the efficacy of n-3 PUFAs on GI cancer patients undergoing surgery. Methods: A systematic search of PubMed, Cochrane Library databases, EMBASE (until December 2021) was conducted. PRISMA checklist was followed. The data were analyzed by RevMan v5.3.0. Results: A total of ten RCTs articles including 663 patients were studied. The analysis demonstrated that the n-3 PUFAs group significantly reduced levels of interleukin-6 (IL-6) (P = 0.001), C-reactive protein (CRP) (P < 0.00001), tumor necrosis factor-ɑ (TNF-α) (P = 0.0003) compared with the control group. and higher levels of CD4+T cells (P = 0.03), CD8+T cells (P = 0.02) and CD4+/CD8+ratio (P = 0.03) compared with the control group. but there was no significant difference in infection complications rate (P = 0.50) and the level of prealbumin (P = 0.80), albumin (P = 0.21), retinol-binding protein(P = 0.80) between the two groups. In addition, the n-3 PUFAs group significantly reduced the length of hospital stay (P = 0.007). Conclusion: Our meta-analysis shows that n-3 PUFAs can effectively improve the immune function of patients undergoing gastrointestinal cancer surgery, reduce inflammatory response and reduce the length of hospital stay, But it has no significant impact on the incidence of infectious-related complications and the level of nutrient protein. |
| first_indexed | 2024-04-14T04:53:36Z |
| format | Article |
| id | doaj.art-08cf113691204ccb8e9118028cb97f57 |
| institution | Directory Open Access Journal |
| issn | 2666-5662 |
| language | English |
| last_indexed | 2024-04-14T04:53:36Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Chemistry: Molecular Sciences |
| spelling | doaj.art-08cf113691204ccb8e9118028cb97f572022-12-22T02:11:12ZengElsevierFood Chemistry: Molecular Sciences2666-56622022-07-014100099Associations between omega-3 polyunsaturated fatty acids supplementation and surgical prognosis in patients with gastrointestinal cancer: A systematic review and meta-analysisShuai Lu0Zhenpeng Yang1Huazhen Tang2Xibo Sun3Bing Wang4Jinxiu Qu5Yuying Wang6Penghui Yang7Benqiang Rao8Department of General Surgery, Beijing Shijitan Hospital Affiliated Capital Medical University, Beijing 100038, China; Key Laboratory of Cancer Foods for Special Medical Purpose (FSMP) for State Market Regulation, Beijing 100038, ChinaDepartment of General Surgery, Beijing Shijitan Hospital Affiliated Capital Medical University, Beijing 100038, China; Key Laboratory of Cancer Foods for Special Medical Purpose (FSMP) for State Market Regulation, Beijing 100038, ChinaDepartment of General Surgery, Beijing Shijitan Hospital Affiliated Capital Medical University, Beijing 100038, China; Key Laboratory of Cancer Foods for Special Medical Purpose (FSMP) for State Market Regulation, Beijing 100038, ChinaDepartment of Breast Surgery, The Second Affiliated Hospital of Shandong First Medical University, Shandong 271000, ChinaDepartment of General Surgery, Beijing Shijitan Hospital Affiliated Capital Medical University, Beijing 100038, China; Key Laboratory of Cancer Foods for Special Medical Purpose (FSMP) for State Market Regulation, Beijing 100038, ChinaDepartment of General Surgery, Beijing Shijitan Hospital Affiliated Capital Medical University, Beijing 100038, China; Key Laboratory of Cancer Foods for Special Medical Purpose (FSMP) for State Market Regulation, Beijing 100038, ChinaDepartment of General Surgery, Beijing Shijitan Hospital Affiliated Capital Medical University, Beijing 100038, China; Key Laboratory of Cancer Foods for Special Medical Purpose (FSMP) for State Market Regulation, Beijing 100038, ChinaThe Fifth Medical Center of PLA General Hospital, Beijing 100039, China; Corresponding authors at: The Fifth Medical Center of PLA General Hospital, Beijing 100039, China (P. Yang); Department of General Surgery, Beijing Shijitan Hospital Affiliated Capital Medical University, Beijing 100038, China; Key Laboratory of Cancer Foods for Special Medical Purpose (FSMP) for State Market Regulation, Beijing 100038, China (B. Rao).Department of General Surgery, Beijing Shijitan Hospital Affiliated Capital Medical University, Beijing 100038, China; Key Laboratory of Cancer Foods for Special Medical Purpose (FSMP) for State Market Regulation, Beijing 100038, China; Corresponding authors at: The Fifth Medical Center of PLA General Hospital, Beijing 100039, China (P. Yang); Department of General Surgery, Beijing Shijitan Hospital Affiliated Capital Medical University, Beijing 100038, China; Key Laboratory of Cancer Foods for Special Medical Purpose (FSMP) for State Market Regulation, Beijing 100038, China (B. Rao).Background: Surgical resection remains the primary treatment for gastrointestinal (GI) cancer, omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to improve the prognosis of patients undergoing gastrointestinal tumor surgery. This meta-analysis aims to explore the efficacy of n-3 PUFAs on GI cancer patients undergoing surgery. Methods: A systematic search of PubMed, Cochrane Library databases, EMBASE (until December 2021) was conducted. PRISMA checklist was followed. The data were analyzed by RevMan v5.3.0. Results: A total of ten RCTs articles including 663 patients were studied. The analysis demonstrated that the n-3 PUFAs group significantly reduced levels of interleukin-6 (IL-6) (P = 0.001), C-reactive protein (CRP) (P < 0.00001), tumor necrosis factor-ɑ (TNF-α) (P = 0.0003) compared with the control group. and higher levels of CD4+T cells (P = 0.03), CD8+T cells (P = 0.02) and CD4+/CD8+ratio (P = 0.03) compared with the control group. but there was no significant difference in infection complications rate (P = 0.50) and the level of prealbumin (P = 0.80), albumin (P = 0.21), retinol-binding protein(P = 0.80) between the two groups. In addition, the n-3 PUFAs group significantly reduced the length of hospital stay (P = 0.007). Conclusion: Our meta-analysis shows that n-3 PUFAs can effectively improve the immune function of patients undergoing gastrointestinal cancer surgery, reduce inflammatory response and reduce the length of hospital stay, But it has no significant impact on the incidence of infectious-related complications and the level of nutrient protein.http://www.sciencedirect.com/science/article/pii/S2666566222000272Omega-3 fatty acidsGastrointestinal cancerImmune functionInflammatory response |
| spellingShingle | Shuai Lu Zhenpeng Yang Huazhen Tang Xibo Sun Bing Wang Jinxiu Qu Yuying Wang Penghui Yang Benqiang Rao Associations between omega-3 polyunsaturated fatty acids supplementation and surgical prognosis in patients with gastrointestinal cancer: A systematic review and meta-analysis Food Chemistry: Molecular Sciences Omega-3 fatty acids Gastrointestinal cancer Immune function Inflammatory response |
| title | Associations between omega-3 polyunsaturated fatty acids supplementation and surgical prognosis in patients with gastrointestinal cancer: A systematic review and meta-analysis |
| title_full | Associations between omega-3 polyunsaturated fatty acids supplementation and surgical prognosis in patients with gastrointestinal cancer: A systematic review and meta-analysis |
| title_fullStr | Associations between omega-3 polyunsaturated fatty acids supplementation and surgical prognosis in patients with gastrointestinal cancer: A systematic review and meta-analysis |
| title_full_unstemmed | Associations between omega-3 polyunsaturated fatty acids supplementation and surgical prognosis in patients with gastrointestinal cancer: A systematic review and meta-analysis |
| title_short | Associations between omega-3 polyunsaturated fatty acids supplementation and surgical prognosis in patients with gastrointestinal cancer: A systematic review and meta-analysis |
| title_sort | associations between omega 3 polyunsaturated fatty acids supplementation and surgical prognosis in patients with gastrointestinal cancer a systematic review and meta analysis |
| topic | Omega-3 fatty acids Gastrointestinal cancer Immune function Inflammatory response |
| url | http://www.sciencedirect.com/science/article/pii/S2666566222000272 |
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