Tacrolimus in Solution as an Option to Inflammatory Conditions of the Scalp
Introduction: Several dermatological diseases lead to inflammatory conditions of the scalp. Most of these afflictions are recalcitrant and require long term maintenance treatment. Objectives: We present a case series where topical tacrolimus was used in a solution vehicle for these conditions. Met...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Mattioli1885
2023-04-01
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| Series: | Dermatology Practical & Conceptual |
| Subjects: | |
| Online Access: | https://dpcj.org/index.php/dpc/article/view/2664 |
| _version_ | 1827954901139849216 |
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| author | Camila Scharf Gaetano Licata Giulia Briatico Sebastiano Pellerone Giuseppe Argenziano Caterina Mariarosaria Giorgio |
| author_facet | Camila Scharf Gaetano Licata Giulia Briatico Sebastiano Pellerone Giuseppe Argenziano Caterina Mariarosaria Giorgio |
| author_sort | Camila Scharf |
| collection | DOAJ |
| description | Introduction: Several dermatological diseases lead to inflammatory conditions of the scalp. Most of these afflictions are recalcitrant and require long term maintenance treatment.
Objectives: We present a case series where topical tacrolimus was used in a solution vehicle for these conditions.
Methods: A total of 22 patients (aged 24-90 years) with confirmed diagnosis of lichen planus pilaris (LPP),discoid lupus (DL),frontal fibrosing alopecia (FFA),erosive pustulosis of the scalp (EPS) or folliculitis decalvans (FD) were evaluated and treated with tacrolimus solution (0.1%) applied twice daily for 1 month, then once daily for another month and alternate days for 4 months. Efficacy was evaluated by an investigator global assessment,clinical and dermoscopic evaluation at weeks 4,8 and 24.The safety assessment included monitoring of all adverse events.
Results: The study included 13 patients with LPP, 2 with DL, 2 with FD, 2 with EPS and 3 with AFF.After 1 month, 14 patients (63.6%) had a good response and 7 (31.8%) had excellent response.After 2 months, 16 patients (72.7%) had excellent response, and this response was persistent after 6 months of treatment.
Conclusions: Tacrolimus in solution,even if not yet commercially available,was an effective and well tolerated alternative for the maintenance treatment of inflammatory conditions of the scalp.
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| first_indexed | 2024-04-09T14:36:29Z |
| format | Article |
| id | doaj.art-08cfa1ea9c974577a20911bb3a5906af |
| institution | Directory Open Access Journal |
| issn | 2160-9381 |
| language | English |
| last_indexed | 2024-04-09T14:36:29Z |
| publishDate | 2023-04-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj.art-08cfa1ea9c974577a20911bb3a5906af2023-05-03T12:00:37ZengMattioli1885Dermatology Practical & Conceptual2160-93812023-04-0113210.5826/dpc.1302a89Tacrolimus in Solution as an Option to Inflammatory Conditions of the ScalpCamila Scharf0Gaetano Licata1Giulia Briatico2Sebastiano Pellerone3Giuseppe Argenziano4Caterina Mariarosaria Giorgio5Dermatology Unit, University of Campania L.Vanvitelli, Naples, Italy Dermatology Department, ASST Spedali Civili di Brescia, University of Brescia, Brescia, ItalyDermatology Unit, University of Campania L.Vanvitelli, Naples, Italy Dermatology Unit, University of Campania L.Vanvitelli, Naples, Italy Dermatology Unit, University of Campania L.Vanvitelli, Naples, Italy Dermatology Unit, University of Campania L.Vanvitelli, Naples, Italy Introduction: Several dermatological diseases lead to inflammatory conditions of the scalp. Most of these afflictions are recalcitrant and require long term maintenance treatment. Objectives: We present a case series where topical tacrolimus was used in a solution vehicle for these conditions. Methods: A total of 22 patients (aged 24-90 years) with confirmed diagnosis of lichen planus pilaris (LPP),discoid lupus (DL),frontal fibrosing alopecia (FFA),erosive pustulosis of the scalp (EPS) or folliculitis decalvans (FD) were evaluated and treated with tacrolimus solution (0.1%) applied twice daily for 1 month, then once daily for another month and alternate days for 4 months. Efficacy was evaluated by an investigator global assessment,clinical and dermoscopic evaluation at weeks 4,8 and 24.The safety assessment included monitoring of all adverse events. Results: The study included 13 patients with LPP, 2 with DL, 2 with FD, 2 with EPS and 3 with AFF.After 1 month, 14 patients (63.6%) had a good response and 7 (31.8%) had excellent response.After 2 months, 16 patients (72.7%) had excellent response, and this response was persistent after 6 months of treatment. Conclusions: Tacrolimus in solution,even if not yet commercially available,was an effective and well tolerated alternative for the maintenance treatment of inflammatory conditions of the scalp. https://dpcj.org/index.php/dpc/article/view/2664TacrolimusLichen Planus PilarisDiscoid LupusFrontal Fibrosing AlopeciaFolliculitis Decalvans |
| spellingShingle | Camila Scharf Gaetano Licata Giulia Briatico Sebastiano Pellerone Giuseppe Argenziano Caterina Mariarosaria Giorgio Tacrolimus in Solution as an Option to Inflammatory Conditions of the Scalp Dermatology Practical & Conceptual Tacrolimus Lichen Planus Pilaris Discoid Lupus Frontal Fibrosing Alopecia Folliculitis Decalvans |
| title | Tacrolimus in Solution as an Option to Inflammatory Conditions of the Scalp |
| title_full | Tacrolimus in Solution as an Option to Inflammatory Conditions of the Scalp |
| title_fullStr | Tacrolimus in Solution as an Option to Inflammatory Conditions of the Scalp |
| title_full_unstemmed | Tacrolimus in Solution as an Option to Inflammatory Conditions of the Scalp |
| title_short | Tacrolimus in Solution as an Option to Inflammatory Conditions of the Scalp |
| title_sort | tacrolimus in solution as an option to inflammatory conditions of the scalp |
| topic | Tacrolimus Lichen Planus Pilaris Discoid Lupus Frontal Fibrosing Alopecia Folliculitis Decalvans |
| url | https://dpcj.org/index.php/dpc/article/view/2664 |
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