HIV-1 with multiple CCR5/CXCR4 chimeric receptor use is predictive of immunological failure in infected children.

HIV-1 with multiple CCR5/CXCR4 chimeric receptor use is predictive of immunological failure in infected children.

BACKGROUND: HIV-1 R5 viruses are characterized by a large phenotypic variation, that is reflected by the mode of coreceptor use. The ability of R5 HIV-1 to infect target cells expressing chimeric receptors between CCR5 and CXCR4 (R5(broad) viruses), was shown to correlate with disease stage in HIV-1...

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Bibliographic Details
Main Authors: Mariangela Cavarelli, Ingrid Karlsson, Marisa Zanchetta, Liselotte Antonsson, Anna Plebani, Carlo Giaquinto, Eva Maria Fenyö, Anita De Rossi, Gabriella Scarlatti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2538568?pdf=render

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