Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation
Traditional inert materials used in internal fixation have caused many complications and generally require removal with secondary surgeries. Biodegradable materials, such as magnesium (Mg)-, iron (Fe)- and zinc (Zn)-based alloys, open up a new pathway to address those issues. During the last decades...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/4/164 |
| _version_ | 1797456974656307200 |
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| author | Yang Liu Tianming Du Aike Qiao Yongliang Mu Haisheng Yang |
| author_facet | Yang Liu Tianming Du Aike Qiao Yongliang Mu Haisheng Yang |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | Traditional inert materials used in internal fixation have caused many complications and generally require removal with secondary surgeries. Biodegradable materials, such as magnesium (Mg)-, iron (Fe)- and zinc (Zn)-based alloys, open up a new pathway to address those issues. During the last decades, Mg-based alloys have attracted much attention by researchers. However, the issues with an over-fast degradation rate and release of hydrogen still need to be overcome. Zn alloys have comparable mechanical properties with traditional metal materials, e.g., titanium (Ti), and have a moderate degradation rate, potentially serving as a good candidate for internal fixation materials, especially at load-bearing sites of the skeleton. Emerging Zn-based alloys and composites have been developed in recent years and in vitro and in vivo studies have been performed to explore their biodegradability, mechanical property, and biocompatibility in order to move towards the ultimate goal of clinical application in fracture fixation. This article seeks to offer a review of related research progress on Zn-based biodegradable materials, which may provide a useful reference for future studies on Zn-based biodegradable materials targeting applications in orthopedic internal fixation. |
| first_indexed | 2024-03-09T16:15:29Z |
| format | Article |
| id | doaj.art-08d42c3f8c6e40b5ae60878390d9a1ad |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:15:29Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-08d42c3f8c6e40b5ae60878390d9a1ad2023-11-24T15:48:43ZengMDPI AGJournal of Functional Biomaterials2079-49832022-09-0113416410.3390/jfb13040164Zinc-Based Biodegradable Materials for Orthopaedic Internal FixationYang Liu0Tianming Du1Aike Qiao2Yongliang Mu3Haisheng Yang4Department of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, ChinaDepartment of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, ChinaDepartment of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, ChinaSchool of Metallurgy, Northeastern University, Shenyang 110819, ChinaDepartment of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, ChinaTraditional inert materials used in internal fixation have caused many complications and generally require removal with secondary surgeries. Biodegradable materials, such as magnesium (Mg)-, iron (Fe)- and zinc (Zn)-based alloys, open up a new pathway to address those issues. During the last decades, Mg-based alloys have attracted much attention by researchers. However, the issues with an over-fast degradation rate and release of hydrogen still need to be overcome. Zn alloys have comparable mechanical properties with traditional metal materials, e.g., titanium (Ti), and have a moderate degradation rate, potentially serving as a good candidate for internal fixation materials, especially at load-bearing sites of the skeleton. Emerging Zn-based alloys and composites have been developed in recent years and in vitro and in vivo studies have been performed to explore their biodegradability, mechanical property, and biocompatibility in order to move towards the ultimate goal of clinical application in fracture fixation. This article seeks to offer a review of related research progress on Zn-based biodegradable materials, which may provide a useful reference for future studies on Zn-based biodegradable materials targeting applications in orthopedic internal fixation.https://www.mdpi.com/2079-4983/13/4/164Zinc-based biodegradable materialsorthopedic implantbiodegradabilitymechanical propertybiocompatibility |
| spellingShingle | Yang Liu Tianming Du Aike Qiao Yongliang Mu Haisheng Yang Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation Journal of Functional Biomaterials Zinc-based biodegradable materials orthopedic implant biodegradability mechanical property biocompatibility |
| title | Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation |
| title_full | Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation |
| title_fullStr | Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation |
| title_full_unstemmed | Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation |
| title_short | Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation |
| title_sort | zinc based biodegradable materials for orthopaedic internal fixation |
| topic | Zinc-based biodegradable materials orthopedic implant biodegradability mechanical property biocompatibility |
| url | https://www.mdpi.com/2079-4983/13/4/164 |
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