Maternal and Fetal Outcomes in Pregnancies affected by Bone and Soft Tissue Tumors
Abstract Objective This study was aimed to describe perinatal outcome of a cohort of pregnant patients with bone and soft tissue tumors and to compare the current series with our group's previously reported experience. Methods Pregnant women diagnosed before and during...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2018-10-01
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| Series: | American Journal of Perinatology Reports |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676289 |
| _version_ | 1818324552710619136 |
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| author | Ernesto Antonio Figueiro-Filho Hythem Al-Sum Jacqueline Parrish Jay S. Wunder Cynthia Maxwell |
| author_facet | Ernesto Antonio Figueiro-Filho Hythem Al-Sum Jacqueline Parrish Jay S. Wunder Cynthia Maxwell |
| author_sort | Ernesto Antonio Figueiro-Filho |
| collection | DOAJ |
| description | Abstract
Objective This study was aimed to describe perinatal outcome of a cohort of pregnant patients with bone and soft tissue tumors and to compare the current series with our group's previously reported experience.
Methods Pregnant women diagnosed before and during pregnancy were identified, retrospectively, for the years 2004 to 2014. Relevant maternal and neonatal data were collected.
Results Forty-eight patients were identified. Ten cases were diagnosed during pregnancy. Pelvis, abdomen, and extremities were the most common tumor locations. Osteosarcoma, liposarcoma, and Ewing's sarcoma were the most common histological types and comprise more than 50% of the cases. Metastases occurred in nine cases. Most of the cases (60%) were treated surgically during pregnancy and delivery occurred at term. Chemotherapy was delayed until after delivery. There were no perinatal or infant deaths. Patients presented with advanced maternal disease in 18% in previous report (1983–2003) versus 40% in present report (2004–2014). Metastases were present in 40% and maternal death rate was approximately 20% in both cohorts.
Conclusion Pregnant women with bone and soft tissue tumors are candidates for standard surgical management during pregnancy. Other treatments, such as chemotherapy and radiotherapy must be evaluated for each woman on a case-by-case basis. Iatrogenic prematurity was common in our findings. |
| first_indexed | 2024-12-13T11:30:24Z |
| format | Article |
| id | doaj.art-08d4d58cbd9b444d811e4c52f58e2ee0 |
| institution | Directory Open Access Journal |
| issn | 2157-6998 2157-7005 |
| language | English |
| last_indexed | 2024-12-13T11:30:24Z |
| publishDate | 2018-10-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | American Journal of Perinatology Reports |
| spelling | doaj.art-08d4d58cbd9b444d811e4c52f58e2ee02022-12-21T23:47:56ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052018-10-010804e343e34810.1055/s-0038-1676289Maternal and Fetal Outcomes in Pregnancies affected by Bone and Soft Tissue TumorsErnesto Antonio Figueiro-Filho0Hythem Al-Sum1Jacqueline Parrish2Jay S. Wunder3Cynthia Maxwell4Division of Maternal-Fetal Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaDivision of Maternal-Fetal Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi ArabiaDivision of Maternal-Fetal Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaMusculoskeletal Oncology Unit, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaDivision of Maternal-Fetal Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaAbstract Objective This study was aimed to describe perinatal outcome of a cohort of pregnant patients with bone and soft tissue tumors and to compare the current series with our group's previously reported experience. Methods Pregnant women diagnosed before and during pregnancy were identified, retrospectively, for the years 2004 to 2014. Relevant maternal and neonatal data were collected. Results Forty-eight patients were identified. Ten cases were diagnosed during pregnancy. Pelvis, abdomen, and extremities were the most common tumor locations. Osteosarcoma, liposarcoma, and Ewing's sarcoma were the most common histological types and comprise more than 50% of the cases. Metastases occurred in nine cases. Most of the cases (60%) were treated surgically during pregnancy and delivery occurred at term. Chemotherapy was delayed until after delivery. There were no perinatal or infant deaths. Patients presented with advanced maternal disease in 18% in previous report (1983–2003) versus 40% in present report (2004–2014). Metastases were present in 40% and maternal death rate was approximately 20% in both cohorts. Conclusion Pregnant women with bone and soft tissue tumors are candidates for standard surgical management during pregnancy. Other treatments, such as chemotherapy and radiotherapy must be evaluated for each woman on a case-by-case basis. Iatrogenic prematurity was common in our findings.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676289sarcomascancerpregnancyoutcomesperinatal |
| spellingShingle | Ernesto Antonio Figueiro-Filho Hythem Al-Sum Jacqueline Parrish Jay S. Wunder Cynthia Maxwell Maternal and Fetal Outcomes in Pregnancies affected by Bone and Soft Tissue Tumors American Journal of Perinatology Reports sarcomas cancer pregnancy outcomes perinatal |
| title | Maternal and Fetal Outcomes in Pregnancies affected by Bone and Soft Tissue Tumors |
| title_full | Maternal and Fetal Outcomes in Pregnancies affected by Bone and Soft Tissue Tumors |
| title_fullStr | Maternal and Fetal Outcomes in Pregnancies affected by Bone and Soft Tissue Tumors |
| title_full_unstemmed | Maternal and Fetal Outcomes in Pregnancies affected by Bone and Soft Tissue Tumors |
| title_short | Maternal and Fetal Outcomes in Pregnancies affected by Bone and Soft Tissue Tumors |
| title_sort | maternal and fetal outcomes in pregnancies affected by bone and soft tissue tumors |
| topic | sarcomas cancer pregnancy outcomes perinatal |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676289 |
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