The role of the GABA system in amphetamine-type stimulant use disorders
Abuse of amphetamine-type stimulants (ATS) has become a global public health problem. ATS causes severe neurotoxicity, which could lead to addiction and could induce psychotic disorders or cognitive dysfunctions. However, until now, there has been a lack of effective medicines for treating ATS-relat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-05-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00162/full |
| _version_ | 1818694958582857728 |
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| author | Dongliang eJiao Yao eLiu Xiaohong eLi Jinggen eLiu Min eZhao |
| author_facet | Dongliang eJiao Yao eLiu Xiaohong eLi Jinggen eLiu Min eZhao |
| author_sort | Dongliang eJiao |
| collection | DOAJ |
| description | Abuse of amphetamine-type stimulants (ATS) has become a global public health problem. ATS causes severe neurotoxicity, which could lead to addiction and could induce psychotic disorders or cognitive dysfunctions. However, until now, there has been a lack of effective medicines for treating ATS-related problems. Findings from recent studies indicate that in addition to the traditional dopamine-ergic system, the GABA (gamma-aminobutyric acid)-ergic system plays an important role in ATS abuse. However the exact mechanisms of the GABA-ergic system in amphetamine-type stimulant use disorders are not fully understood. This review discusses the role of the GABA-ergic system in ATS use disorders, including ATS induced psychotic disorders and cognitive dysfunctions. We conclude that the GABA-ergic system are importantly involved in the development of ATS use disorders through multiple pathways, and that therapies or medicines that target specific members of the GABA-ergic system may be novel effective interventions for the treatment of ATS use disorders. |
| first_indexed | 2024-12-17T13:37:51Z |
| format | Article |
| id | doaj.art-08d51c3be9ed4b4281c301e138376d33 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-17T13:37:51Z |
| publishDate | 2015-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-08d51c3be9ed4b4281c301e138376d332022-12-21T21:46:22ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-05-01910.3389/fncel.2015.00162136870The role of the GABA system in amphetamine-type stimulant use disordersDongliang eJiao0Yao eLiu1Xiaohong eLi2Jinggen eLiu3Min eZhao4State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of SciencesState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of SciencesState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of SciencesState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of SciencesState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of SciencesAbuse of amphetamine-type stimulants (ATS) has become a global public health problem. ATS causes severe neurotoxicity, which could lead to addiction and could induce psychotic disorders or cognitive dysfunctions. However, until now, there has been a lack of effective medicines for treating ATS-related problems. Findings from recent studies indicate that in addition to the traditional dopamine-ergic system, the GABA (gamma-aminobutyric acid)-ergic system plays an important role in ATS abuse. However the exact mechanisms of the GABA-ergic system in amphetamine-type stimulant use disorders are not fully understood. This review discusses the role of the GABA-ergic system in ATS use disorders, including ATS induced psychotic disorders and cognitive dysfunctions. We conclude that the GABA-ergic system are importantly involved in the development of ATS use disorders through multiple pathways, and that therapies or medicines that target specific members of the GABA-ergic system may be novel effective interventions for the treatment of ATS use disorders.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00162/fullNeuronsDrug abusepsychoticCognitive dysfunctionsGABA systemamphetamine-type stimulant use disorders |
| spellingShingle | Dongliang eJiao Yao eLiu Xiaohong eLi Jinggen eLiu Min eZhao The role of the GABA system in amphetamine-type stimulant use disorders Frontiers in Cellular Neuroscience Neurons Drug abuse psychotic Cognitive dysfunctions GABA system amphetamine-type stimulant use disorders |
| title | The role of the GABA system in amphetamine-type stimulant use disorders |
| title_full | The role of the GABA system in amphetamine-type stimulant use disorders |
| title_fullStr | The role of the GABA system in amphetamine-type stimulant use disorders |
| title_full_unstemmed | The role of the GABA system in amphetamine-type stimulant use disorders |
| title_short | The role of the GABA system in amphetamine-type stimulant use disorders |
| title_sort | role of the gaba system in amphetamine type stimulant use disorders |
| topic | Neurons Drug abuse psychotic Cognitive dysfunctions GABA system amphetamine-type stimulant use disorders |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00162/full |
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