Recombinant botulinum neurotoxin serotype A1 in vivo characterization

Recombinant botulinum neurotoxin serotype A1 in vivo characterization

Abstract Clinically used botulinum neurotoxins (BoNTs) are natural products of Clostridium botulinum. A novel, recombinant BoNT type A1 (rBoNT/A1; IPN10260) has been synthesized using the native amino acid sequence expressed in Escherichia coli and has previously been characterized in vitro and ex v...

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Main Authors: Cindy Périer, Vincent Martin, Sylvie Cornet, Christine Favre‐Guilmard, Marie‐Noelle Rocher, Julien Bindler, Stéphanie Wagner, Emile Andriambeloson, Brian B. Rudkin, Rudy Marty, Alban Vignaud, Matthew Beard, Stephane Lezmi, Mikhail Kalinichev
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Pharmacology Research & Perspectives
Subjects:
botulinum
muscle
neurotoxin
recombinant
rodent
SNAP25
Online Access:https://doi.org/10.1002/prp2.857

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