Influence of a Heterologous (ChAdOx1-nCoV-19/BNT162b2) or Homologous (BNT162b2/BNT162b2) Vaccination Regimen on the Antibody and T Cell Response to a Third Vaccination with BNT162b2
Emerging numbers of SARS-CoV-2 infections are currently combated with a third vaccination. Considering the different vaccination regimens used for the first two vaccine doses, we addressed whether the previous vaccination influences the immune response to the booster. Participants for this prospecti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/5/788 |
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| author | Rieke Reiter Pia Von Blanckenburg Reinier Mutters Julia Thiemer Reinhard Geßner Ulf Seifart |
| author_facet | Rieke Reiter Pia Von Blanckenburg Reinier Mutters Julia Thiemer Reinhard Geßner Ulf Seifart |
| author_sort | Rieke Reiter |
| collection | DOAJ |
| description | Emerging numbers of SARS-CoV-2 infections are currently combated with a third vaccination. Considering the different vaccination regimens used for the first two vaccine doses, we addressed whether the previous vaccination influences the immune response to the booster. Participants for this prospective study were recruited from among healthcare workers. N = 20 participants were previously vaccinated with two doses of BNT162b2, and n = 53 received a priming dose of ChAdOx1-nCoV-19 followed by a BNT162b2 dose. Participants were vaccinated with a third dose of BNT162b2 in December 2021. Antibody concentrations were determined after vaccination, and in a subset of n = 19 participants, T cell responses were evaluated. Anti-S concentrations and IFNγ production increased during the first 21 days. The choice of the first and second vaccineshad no influence on the final outcome of the booster vaccination. Before booster vaccination, antibody concentrations were lower for older participants but increased more strongly over time. |
| first_indexed | 2024-03-10T01:39:02Z |
| format | Article |
| id | doaj.art-08d7fdd9b0804fd4bd122f730ab3a849 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T01:39:02Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-08d7fdd9b0804fd4bd122f730ab3a8492023-11-23T13:27:16ZengMDPI AGVaccines2076-393X2022-05-0110578810.3390/vaccines10050788Influence of a Heterologous (ChAdOx1-nCoV-19/BNT162b2) or Homologous (BNT162b2/BNT162b2) Vaccination Regimen on the Antibody and T Cell Response to a Third Vaccination with BNT162b2Rieke Reiter0Pia Von Blanckenburg1Reinier Mutters2Julia Thiemer3Reinhard Geßner4Ulf Seifart5Institute of Laboratory Medicine, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, GermanyDepartment of Clinical Psychology and Psychotherapy, Philipps University Marburg, Gutenbergstr. 18, 35041 Marburg, GermanyInstitute of Medical Microbiology and Hygiene, Philipps University Marburg, Hans-Meerwein-Str. 2, 35043 Marburg, GermanyKlinik Sonnenblick, Amöneburgerstr. 1-6, 35043 Marburg, GermanyInstitute of Laboratory Medicine, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, GermanyKlinik Sonnenblick, Amöneburgerstr. 1-6, 35043 Marburg, GermanyEmerging numbers of SARS-CoV-2 infections are currently combated with a third vaccination. Considering the different vaccination regimens used for the first two vaccine doses, we addressed whether the previous vaccination influences the immune response to the booster. Participants for this prospective study were recruited from among healthcare workers. N = 20 participants were previously vaccinated with two doses of BNT162b2, and n = 53 received a priming dose of ChAdOx1-nCoV-19 followed by a BNT162b2 dose. Participants were vaccinated with a third dose of BNT162b2 in December 2021. Antibody concentrations were determined after vaccination, and in a subset of n = 19 participants, T cell responses were evaluated. Anti-S concentrations and IFNγ production increased during the first 21 days. The choice of the first and second vaccineshad no influence on the final outcome of the booster vaccination. Before booster vaccination, antibody concentrations were lower for older participants but increased more strongly over time.https://www.mdpi.com/2076-393X/10/5/788SARS-CoV-2boosterthird vaccinationBNT162b2ChAdOx1-nCoV-19T cell response |
| spellingShingle | Rieke Reiter Pia Von Blanckenburg Reinier Mutters Julia Thiemer Reinhard Geßner Ulf Seifart Influence of a Heterologous (ChAdOx1-nCoV-19/BNT162b2) or Homologous (BNT162b2/BNT162b2) Vaccination Regimen on the Antibody and T Cell Response to a Third Vaccination with BNT162b2 Vaccines SARS-CoV-2 booster third vaccination BNT162b2 ChAdOx1-nCoV-19 T cell response |
| title | Influence of a Heterologous (ChAdOx1-nCoV-19/BNT162b2) or Homologous (BNT162b2/BNT162b2) Vaccination Regimen on the Antibody and T Cell Response to a Third Vaccination with BNT162b2 |
| title_full | Influence of a Heterologous (ChAdOx1-nCoV-19/BNT162b2) or Homologous (BNT162b2/BNT162b2) Vaccination Regimen on the Antibody and T Cell Response to a Third Vaccination with BNT162b2 |
| title_fullStr | Influence of a Heterologous (ChAdOx1-nCoV-19/BNT162b2) or Homologous (BNT162b2/BNT162b2) Vaccination Regimen on the Antibody and T Cell Response to a Third Vaccination with BNT162b2 |
| title_full_unstemmed | Influence of a Heterologous (ChAdOx1-nCoV-19/BNT162b2) or Homologous (BNT162b2/BNT162b2) Vaccination Regimen on the Antibody and T Cell Response to a Third Vaccination with BNT162b2 |
| title_short | Influence of a Heterologous (ChAdOx1-nCoV-19/BNT162b2) or Homologous (BNT162b2/BNT162b2) Vaccination Regimen on the Antibody and T Cell Response to a Third Vaccination with BNT162b2 |
| title_sort | influence of a heterologous chadox1 ncov 19 bnt162b2 or homologous bnt162b2 bnt162b2 vaccination regimen on the antibody and t cell response to a third vaccination with bnt162b2 |
| topic | SARS-CoV-2 booster third vaccination BNT162b2 ChAdOx1-nCoV-19 T cell response |
| url | https://www.mdpi.com/2076-393X/10/5/788 |
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