Downregulation of mitochondrial complex I induces ROS production in colorectal cancer subtypes that differently controls migration

Downregulation of mitochondrial complex I induces ROS production in colorectal cancer subtypes that differently controls migration

Abstract Background Colorectal cancer (CRC) can be classified into four molecular subtypes (CMS) among which CMS1 is associated with the best prognosis, while CMS4, the mesenchymal subtype, has the worst outcome. Although mitochondria are considered to be hubs of numerous signaling pathways, the stu...

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Bibliographic Details
Main Authors: Jean Bastin, Marine Sroussi, Ivan Nemazanyy, Pierre Laurent-Puig, Sophie Mouillet-Richard, Fatima Djouadi
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Translational Medicine
Subjects:
Colorectal cancer
Mitochondria
Complex I
Reactive oxygen species
SOD2
Consensus Molecular Subtypes (CMS)
Online Access:https://doi.org/10.1186/s12967-023-04341-x

Internet

https://doi.org/10.1186/s12967-023-04341-x

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