Acute restraint stress impairs histamine type 2 receptor ability to increase the excitability of medium spiny neurons in the nucleus accumbens

Acute restraint stress impairs histamine type 2 receptor ability to increase the excitability of medium spiny neurons in the nucleus accumbens

Histamine, a monoamine implicated in stress-related arousal states, is synthesized in neurons exclusively located in the hypothalamic tuberomammillary nucleus (TMN) from where they diffusely innervate striatal and mesolimbic networks including the nucleus accumbens (NAc), a vital node in the limbic...

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Bibliographic Details
Main Authors: Giuseppe Aceto, Luca Nardella, Giacomo Lazzarino, Barbara Tavazzi, Alessia Bertozzi, Simona Nanni, Claudia Colussi, Marcello D'Ascenzo, Claudio Grassi
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Neurobiology of Disease
Subjects:
Acute restraint stress
Histamine
H2 receptor
Kv4.2
Nucleus accumbens
Intrinsic excitability
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122003242

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