Correlation of lactate dehydrogenase levels with outcome in patients with pre-eclampsia
Background: Pregnancy causes profound anatomical, physiological and metabolic changes in maternal tissues. Lactate dehydrogenase (LDH) is an intracellular enzyme. Hence, the present study was undertaken for assessing and correlating LDH levels with outcome in patients with preeclampsia. Materials an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Advances in Human Biology |
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| Online Access: | http://www.aihbonline.com/article.asp?issn=2321-8568;year=2020;volume=10;issue=3;spage=149;epage=152;aulast= |
| _version_ | 1828877251505029120 |
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| author | Balgopal Singh Bhati Nooren Mirza Praveen Kumar Choudhary |
| author_facet | Balgopal Singh Bhati Nooren Mirza Praveen Kumar Choudhary |
| author_sort | Balgopal Singh Bhati |
| collection | DOAJ |
| description | Background: Pregnancy causes profound anatomical, physiological and metabolic changes in maternal tissues. Lactate dehydrogenase (LDH) is an intracellular enzyme. Hence, the present study was undertaken for assessing and correlating LDH levels with outcome in patients with preeclampsia. Materials and Methods: A total of 60 pregnant women with pre-eclampsia (PE) were included in the present study. Among these 60 patients, 30 patients were mild PE while the remaining 30 patients were of severe PE. Another set of 30 subjects of normotensive pregnancy were included as controlled group. Blood samples were obtained from all the subjects and were sent to laboratory where auto-analyser was used for the evaluation of serum LDH levels. Follow-up was done and outcome was recorded in all the patients. All the results were recorded into Microsoft excel sheet and were analysed by SPSS software. Results: Mean LDH levels amongst subjects of normotensive group, mild PE group and severe PE group was found to be 169.2 IU/L, 338.4 IU/L and 629.7 IU/L, respectively. Non-significant results were obtained while comparing the mean gestational age of the patients divided on the basis of mean LDH levels. Significant results were obtained while comparing the neonatal complications and neonatal mortality amongst patients divided on the basis of LDH levels. Conclusion: Significant alteration of LDH levels occurs in PE patients. In addition, higher levels of LDH levels are significantly associated with worse outcome in PE patients. |
| first_indexed | 2024-12-13T08:36:45Z |
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| institution | Directory Open Access Journal |
| issn | 2321-8568 2348-4691 |
| language | English |
| last_indexed | 2024-12-13T08:36:45Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Advances in Human Biology |
| spelling | doaj.art-08dbc8a68bc2427bbf7a588eb5e86ad52022-12-21T23:53:37ZengWolters Kluwer Medknow PublicationsAdvances in Human Biology2321-85682348-46912020-01-0110314915210.4103/AIHB.AIHB_46_20Correlation of lactate dehydrogenase levels with outcome in patients with pre-eclampsiaBalgopal Singh BhatiNooren MirzaPraveen Kumar ChoudharyBackground: Pregnancy causes profound anatomical, physiological and metabolic changes in maternal tissues. Lactate dehydrogenase (LDH) is an intracellular enzyme. Hence, the present study was undertaken for assessing and correlating LDH levels with outcome in patients with preeclampsia. Materials and Methods: A total of 60 pregnant women with pre-eclampsia (PE) were included in the present study. Among these 60 patients, 30 patients were mild PE while the remaining 30 patients were of severe PE. Another set of 30 subjects of normotensive pregnancy were included as controlled group. Blood samples were obtained from all the subjects and were sent to laboratory where auto-analyser was used for the evaluation of serum LDH levels. Follow-up was done and outcome was recorded in all the patients. All the results were recorded into Microsoft excel sheet and were analysed by SPSS software. Results: Mean LDH levels amongst subjects of normotensive group, mild PE group and severe PE group was found to be 169.2 IU/L, 338.4 IU/L and 629.7 IU/L, respectively. Non-significant results were obtained while comparing the mean gestational age of the patients divided on the basis of mean LDH levels. Significant results were obtained while comparing the neonatal complications and neonatal mortality amongst patients divided on the basis of LDH levels. Conclusion: Significant alteration of LDH levels occurs in PE patients. In addition, higher levels of LDH levels are significantly associated with worse outcome in PE patients.http://www.aihbonline.com/article.asp?issn=2321-8568;year=2020;volume=10;issue=3;spage=149;epage=152;aulast=lactate dehydrogenaseoutcomepre-eclampsia |
| spellingShingle | Balgopal Singh Bhati Nooren Mirza Praveen Kumar Choudhary Correlation of lactate dehydrogenase levels with outcome in patients with pre-eclampsia Advances in Human Biology lactate dehydrogenase outcome pre-eclampsia |
| title | Correlation of lactate dehydrogenase levels with outcome in patients with pre-eclampsia |
| title_full | Correlation of lactate dehydrogenase levels with outcome in patients with pre-eclampsia |
| title_fullStr | Correlation of lactate dehydrogenase levels with outcome in patients with pre-eclampsia |
| title_full_unstemmed | Correlation of lactate dehydrogenase levels with outcome in patients with pre-eclampsia |
| title_short | Correlation of lactate dehydrogenase levels with outcome in patients with pre-eclampsia |
| title_sort | correlation of lactate dehydrogenase levels with outcome in patients with pre eclampsia |
| topic | lactate dehydrogenase outcome pre-eclampsia |
| url | http://www.aihbonline.com/article.asp?issn=2321-8568;year=2020;volume=10;issue=3;spage=149;epage=152;aulast= |
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