Hydroxychloroquine-Loaded Chitosan Nanoparticles Induce Anticancer Activity in A549 Lung Cancer Cells: Design, BSA Binding, Molecular Docking, Mechanistic, and Biological Evaluation

Hydroxychloroquine-Loaded Chitosan Nanoparticles Induce Anticancer Activity in A549 Lung Cancer Cells: Design, BSA Binding, Molecular Docking, Mechanistic, and Biological Evaluation

The current study describes the encapsulation of hydroxychloroquine, widely used in traditional medicine due to its diverse pharmacological and medicinal uses, in chitosan nanoparticles (CNPs). This work aims to combine the HCQ drug with CS NPs to generate a novel nanocomposite with improved charact...

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Bibliographic Details
Main Authors: Fawzia I. Elshami, Hadeer A. Shereef, Ibrahim M. El-Mehasseb, Shaban Y. Shaban, Rudi van Eldik
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
A549 lung cancer
nanoparticles
cell penetration
drug affinity
dissociation constants
molecular docking
Online Access:https://www.mdpi.com/1422-0067/24/18/14103

Internet

https://www.mdpi.com/1422-0067/24/18/14103

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