Gradually shifting clinical phenomics in migraine spectrum: a cross-sectional, multicenter study of 5438 patients
Abstract Background The aim of the study was to investigate whether MwoA and MwA are different manifestations of a single disease, distinct clinical entities, or located at two poles of a spectrum. Methods In this cross-sectional study, 5438 patients from 10 hospitals in China were included: 4651 we...
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10194-022-01461-5 |
| _version_ | 1811222903846338560 |
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| author | Ye Ran Ziming Yin Yajun Lian Yanmei Xu Yajie Li Jiale Liu Qun Gu Fanhong Yan Zhaoli Ge Yu Lian Dongmei Hu Sufen Chen Yangyang Wang Xiaolin Wang Rongfei Wang Xiaoyan Chen Jing Liu Mingjie Zhang Xun Han Wei Xie Zhe Yu Ya Cao Yingji Li Ke Li Zhao Dong Shengyuan Yu |
| author_facet | Ye Ran Ziming Yin Yajun Lian Yanmei Xu Yajie Li Jiale Liu Qun Gu Fanhong Yan Zhaoli Ge Yu Lian Dongmei Hu Sufen Chen Yangyang Wang Xiaolin Wang Rongfei Wang Xiaoyan Chen Jing Liu Mingjie Zhang Xun Han Wei Xie Zhe Yu Ya Cao Yingji Li Ke Li Zhao Dong Shengyuan Yu |
| author_sort | Ye Ran |
| collection | DOAJ |
| description | Abstract Background The aim of the study was to investigate whether MwoA and MwA are different manifestations of a single disease, distinct clinical entities, or located at two poles of a spectrum. Methods In this cross-sectional study, 5438 patients from 10 hospitals in China were included: 4651 were diagnosed with migraine without aura (MwoA) and 787 with migraine with aura (MwA). We used a validated standardized electronic survey to collect multidimensional data on headache characteristics and evaluated the similarities and differences between migraine subtypes. To distinguish migraine subtypes, we employed correlational analysis, factor analysis of mixed data (FAMD), and decision tree analysis. Results Compared to MwA, MwoA had more severe headaches, predominantly affected females, were more easily produced by external factors, and were more likely to have accompanying symptoms and premonitory neck stiffness. Patients with MwA are heterogeneous, according to correlation analysis; FAMD divided the subjects into three clear clusters. The majority of the differences between MwoA and MwA were likewise seen when typical aura with migraine headache (AWM) and typical aura with non-migraine headache (AWNM) were compared. Furthermore, decision trees analysis revealed that the chaotic MwA data reduced the decision tree’s accuracy in distinguishing MwoA from MwA, which was significantly increased by splitting MwA into AWM and AWNM. Conclusions The clinical phenomics of headache phenotype varies gradually from MwoA to AWM and AWNM, and AWM is a mid-state between MwoA and AWNM. We tend to regard migraine as a spectrum disorder, and speculate that different migraine subtypes have different “predominant regions” that generate attacks. |
| first_indexed | 2024-04-12T08:22:44Z |
| format | Article |
| id | doaj.art-08dcc29aec6e46ebb1ed49c25c1067b2 |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-04-12T08:22:44Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-08dcc29aec6e46ebb1ed49c25c1067b22022-12-22T03:40:30ZengBMCThe Journal of Headache and Pain1129-23691129-23772022-07-0123111410.1186/s10194-022-01461-5Gradually shifting clinical phenomics in migraine spectrum: a cross-sectional, multicenter study of 5438 patientsYe Ran0Ziming Yin1Yajun Lian2Yanmei Xu3Yajie Li4Jiale Liu5Qun Gu6Fanhong Yan7Zhaoli Ge8Yu Lian9Dongmei Hu10Sufen Chen11Yangyang Wang12Xiaolin Wang13Rongfei Wang14Xiaoyan Chen15Jing Liu16Mingjie Zhang17Xun Han18Wei Xie19Zhe Yu20Ya Cao21Yingji Li22Ke Li23Zhao Dong24Shengyuan Yu25Department of Neurology, International Headache Center, Chinese PLA General HospitalSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and TechnologyDepartment of Neurology, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Neurology, Dingyuan General HospitalDiagnostic Ultrasound Centre, The Centre Hospital of Jilin CityDepartment of neurology, The Centre Hospital of Jilin CityDepartment of Neurology, Huzhou First Peolple’s HospitalDepartment of Neurology, Linyi jinluo HospitalDepartment of Neurology, Shenzhen Second People’s HospitalDepartment of Neurology, Inner Mongolia Xing’an League people’s hospitalDepartment of Neurology, The Second Affiliated Hospital of Shandong First Medical universityDepartment of Neurology, Changsha Central Hospital Affiliated to University of South ChinaPediatric Center, Chinese PLA General HospitalDepartment of Neurology, International Headache Center, Chinese PLA General HospitalDepartment of Neurology, International Headache Center, Chinese PLA General HospitalDepartment of Neurology, International Headache Center, Chinese PLA General HospitalDepartment of Neurology, International Headache Center, Chinese PLA General HospitalDepartment of Neurology, International Headache Center, Chinese PLA General HospitalDepartment of Neurology, International Headache Center, Chinese PLA General HospitalDepartment of Neurology, International Headache Center, Chinese PLA General HospitalDepartment of Neurology, International Headache Center, Chinese PLA General HospitalDepartment of Neurology, International Headache Center, Chinese PLA General HospitalDepartment of Neurology, International Headache Center, Chinese PLA General HospitalDepartment of Neurology, International Headache Center, Chinese PLA General HospitalDepartment of Neurology, International Headache Center, Chinese PLA General HospitalDepartment of Neurology, International Headache Center, Chinese PLA General HospitalAbstract Background The aim of the study was to investigate whether MwoA and MwA are different manifestations of a single disease, distinct clinical entities, or located at two poles of a spectrum. Methods In this cross-sectional study, 5438 patients from 10 hospitals in China were included: 4651 were diagnosed with migraine without aura (MwoA) and 787 with migraine with aura (MwA). We used a validated standardized electronic survey to collect multidimensional data on headache characteristics and evaluated the similarities and differences between migraine subtypes. To distinguish migraine subtypes, we employed correlational analysis, factor analysis of mixed data (FAMD), and decision tree analysis. Results Compared to MwA, MwoA had more severe headaches, predominantly affected females, were more easily produced by external factors, and were more likely to have accompanying symptoms and premonitory neck stiffness. Patients with MwA are heterogeneous, according to correlation analysis; FAMD divided the subjects into three clear clusters. The majority of the differences between MwoA and MwA were likewise seen when typical aura with migraine headache (AWM) and typical aura with non-migraine headache (AWNM) were compared. Furthermore, decision trees analysis revealed that the chaotic MwA data reduced the decision tree’s accuracy in distinguishing MwoA from MwA, which was significantly increased by splitting MwA into AWM and AWNM. Conclusions The clinical phenomics of headache phenotype varies gradually from MwoA to AWM and AWNM, and AWM is a mid-state between MwoA and AWNM. We tend to regard migraine as a spectrum disorder, and speculate that different migraine subtypes have different “predominant regions” that generate attacks.https://doi.org/10.1186/s10194-022-01461-5MigraineMigraine auraMigraine pathophysiologyFactor analysis of mixed dataDecision tree analysis |
| spellingShingle | Ye Ran Ziming Yin Yajun Lian Yanmei Xu Yajie Li Jiale Liu Qun Gu Fanhong Yan Zhaoli Ge Yu Lian Dongmei Hu Sufen Chen Yangyang Wang Xiaolin Wang Rongfei Wang Xiaoyan Chen Jing Liu Mingjie Zhang Xun Han Wei Xie Zhe Yu Ya Cao Yingji Li Ke Li Zhao Dong Shengyuan Yu Gradually shifting clinical phenomics in migraine spectrum: a cross-sectional, multicenter study of 5438 patients The Journal of Headache and Pain Migraine Migraine aura Migraine pathophysiology Factor analysis of mixed data Decision tree analysis |
| title | Gradually shifting clinical phenomics in migraine spectrum: a cross-sectional, multicenter study of 5438 patients |
| title_full | Gradually shifting clinical phenomics in migraine spectrum: a cross-sectional, multicenter study of 5438 patients |
| title_fullStr | Gradually shifting clinical phenomics in migraine spectrum: a cross-sectional, multicenter study of 5438 patients |
| title_full_unstemmed | Gradually shifting clinical phenomics in migraine spectrum: a cross-sectional, multicenter study of 5438 patients |
| title_short | Gradually shifting clinical phenomics in migraine spectrum: a cross-sectional, multicenter study of 5438 patients |
| title_sort | gradually shifting clinical phenomics in migraine spectrum a cross sectional multicenter study of 5438 patients |
| topic | Migraine Migraine aura Migraine pathophysiology Factor analysis of mixed data Decision tree analysis |
| url | https://doi.org/10.1186/s10194-022-01461-5 |
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