Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder
Abstract Impulsive behaviours are common symptoms of attention-deficit hyperactivity disorder (ADHD). Although previous studies have suggested functional models of impulsive behaviour, a full explanation of impulsivity in ADHD remains elusive. To investigate the detailed mechanisms behind impulsive...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-018-24944-5 |
| _version_ | 1818421796947361792 |
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| author | Saori C. Tanaka Noriaki Yahata Ayako Todokoro Yuki Kawakubo Yukiko Kano Yukika Nishimura Ayaka Ishii-Takahashi Fumio Ohtake Kiyoto Kasai |
| author_facet | Saori C. Tanaka Noriaki Yahata Ayako Todokoro Yuki Kawakubo Yukiko Kano Yukika Nishimura Ayaka Ishii-Takahashi Fumio Ohtake Kiyoto Kasai |
| author_sort | Saori C. Tanaka |
| collection | DOAJ |
| description | Abstract Impulsive behaviours are common symptoms of attention-deficit hyperactivity disorder (ADHD). Although previous studies have suggested functional models of impulsive behaviour, a full explanation of impulsivity in ADHD remains elusive. To investigate the detailed mechanisms behind impulsive behaviour in ADHD, we applied an economic intertemporal choice task involving gains and losses to adults with ADHD and healthy controls and measured brain activity by functional magnetic resonance imaging. In the intertemporal choice of future gains, we observed no behavioural or neural difference between the two groups. In the intertemporal choice of future losses, adults with ADHD exhibited higher discount rates than the control participants. Furthermore, a comparison of brain activity representing the sensitivity of future loss in the two groups revealed significantly lower activity in the striatum and higher activity in the amygdala in adults with ADHD than in controls. Our preliminary findings suggest that an altered size sensitivity to future loss is involved in apparent impulsive choice behaviour in adults with ADHD and shed light on the multifaceted impulsivity underlying ADHD. |
| first_indexed | 2024-12-14T13:16:04Z |
| format | Article |
| id | doaj.art-08dcff9774934d0ba03116b6c547becc |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T13:16:04Z |
| publishDate | 2018-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-08dcff9774934d0ba03116b6c547becc2022-12-21T23:00:04ZengNature PortfolioScientific Reports2045-23222018-04-018111110.1038/s41598-018-24944-5Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorderSaori C. Tanaka0Noriaki Yahata1Ayako Todokoro2Yuki Kawakubo3Yukiko Kano4Yukika Nishimura5Ayaka Ishii-Takahashi6Fumio Ohtake7Kiyoto Kasai8ATR Brain Information Communication Research Laboratory GroupDepartment of Neuropsychiatry, Graduate School of Medicine, The University of TokyoDepartment of Child Neuropsychiatry, Graduate School of Medicine, The University of TokyoDepartment of Child Neuropsychiatry, Graduate School of Medicine, The University of TokyoDepartment of Child Neuropsychiatry, Graduate School of Medicine, The University of TokyoDepartment of Neuropsychiatry, Graduate School of Medicine, The University of TokyoDepartment of Child Neuropsychiatry, Graduate School of Medicine, The University of TokyoGraduate School of Economics, Osaka University, 1-7 Machikaneyamacho, ToyonakaDepartment of Neuropsychiatry, Graduate School of Medicine, The University of TokyoAbstract Impulsive behaviours are common symptoms of attention-deficit hyperactivity disorder (ADHD). Although previous studies have suggested functional models of impulsive behaviour, a full explanation of impulsivity in ADHD remains elusive. To investigate the detailed mechanisms behind impulsive behaviour in ADHD, we applied an economic intertemporal choice task involving gains and losses to adults with ADHD and healthy controls and measured brain activity by functional magnetic resonance imaging. In the intertemporal choice of future gains, we observed no behavioural or neural difference between the two groups. In the intertemporal choice of future losses, adults with ADHD exhibited higher discount rates than the control participants. Furthermore, a comparison of brain activity representing the sensitivity of future loss in the two groups revealed significantly lower activity in the striatum and higher activity in the amygdala in adults with ADHD than in controls. Our preliminary findings suggest that an altered size sensitivity to future loss is involved in apparent impulsive choice behaviour in adults with ADHD and shed light on the multifaceted impulsivity underlying ADHD.https://doi.org/10.1038/s41598-018-24944-5 |
| spellingShingle | Saori C. Tanaka Noriaki Yahata Ayako Todokoro Yuki Kawakubo Yukiko Kano Yukika Nishimura Ayaka Ishii-Takahashi Fumio Ohtake Kiyoto Kasai Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder Scientific Reports |
| title | Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder |
| title_full | Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder |
| title_fullStr | Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder |
| title_full_unstemmed | Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder |
| title_short | Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder |
| title_sort | preliminary evidence of altered neural response during intertemporal choice of losses in adult attention deficit hyperactivity disorder |
| url | https://doi.org/10.1038/s41598-018-24944-5 |
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