Discovery of Novel Pleuromutilin Derivatives as Potent Antibacterial Agents for the Treatment of MRSA Infection

Discovery of Novel Pleuromutilin Derivatives as Potent Antibacterial Agents for the Treatment of MRSA Infection

A series of novel pleuromutilin derivatives containing nitrogen groups on the side chain of C14 were synthesized under mild conditions. Most of the synthesized derivatives displayed potent antibacterial activities. Compound <b>9</b> was found to be the most active antibacterial derivativ...

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Bibliographic Details
Main Authors: Han-Qing Fang, Jie Zeng, Shou-Kai Wang, Xiao Wang, Fang Chen, Bo Li, Jie Liu, Zhen Jin, Ya-Hong Liu, You-Zhi Tang
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
antibacterial activity
MRSA
pleuromutilin
SPR
50S ribosome
Online Access:https://www.mdpi.com/1420-3049/27/3/931

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