Discovery of Novel Pleuromutilin Derivatives as Potent Antibacterial Agents for the Treatment of MRSA Infection

Discovery of Novel Pleuromutilin Derivatives as Potent Antibacterial Agents for the Treatment of MRSA Infection

A series of novel pleuromutilin derivatives containing nitrogen groups on the side chain of C14 were synthesized under mild conditions. Most of the synthesized derivatives displayed potent antibacterial activities. Compound <b>9</b> was found to be the most active antibacterial derivativ...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Han-Qing Fang, Jie Zeng, Shou-Kai Wang, Xiao Wang, Fang Chen, Bo Li, Jie Liu, Zhen Jin, Ya-Hong Liu, You-Zhi Tang
Μορφή:	Άρθρο
Γλώσσα:	English
Έκδοση:	MDPI AG 2022-01-01
Σειρά:	Molecules
Θέματα:	antibacterial activity MRSA pleuromutilin SPR 50S ribosome
Διαθέσιμο Online:	https://www.mdpi.com/1420-3049/27/3/931

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ανά: Ruo-Feng Shang, κ.ά.
Έκδοση: (2014-11-01)

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ανά: Xiangyi Zuo, κ.ά.
Έκδοση: (2020-02-01)

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Έκδοση: (2023-06-01)

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ανά: Xiang-Yi Zuo, κ.ά.
Έκδοση: (2021-06-01)

Synthesis, testing, and computational modeling of pleuromutilin 1,2,3-triazole derivatives in the ribosome
ανά: Logan M. Breiner, κ.ά.
Έκδοση: (2022-12-01)

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ανά: Kerrin Hainsworth, κ.ά.
Έκδοση: (2024-10-01)

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ανά: Kenneth Sue, κ.ά.
Έκδοση: (2023-11-01)

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ανά: Jun Wang, κ.ά.
Έκδοση: (2023-05-01)

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ανά: Fabian Audu Ugbe, κ.ά.
Έκδοση: (2023-05-01)

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ανά: Kate M. J. de Mattos-Shipley, κ.ά.
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ανά: Wenxiang Wang, κ.ά.
Έκδοση: (2024-02-01)

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ανά: Chun-Liu Dong, κ.ά.
Έκδοση: (2017-08-01)

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ανά: Fabian Audu Ugbe, κ.ά.
Έκδοση: (2022-10-01)

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ανά: Kate M. J. de Mattos-Shipley, κ.ά.
Έκδοση: (2021-04-01)

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ανά: Son Thai Le, κ.ά.
Έκδοση: (2021-11-01)

Assessment of the Risk to Public Health due to Use of Antimicrobials in Pigs—An Example of Pleuromutilins in Denmark
ανά: Lis Alban, κ.ά.
Έκδοση: (2017-05-01)

Identification of a New Antimicrobial Resistance Gene Provides Fresh Insights Into Pleuromutilin Resistance in Brachyspira hyodysenteriae, Aetiological Agent of Swine Dysentery
ανά: Roderick M. Card, κ.ά.
Έκδοση: (2018-06-01)

Determination of In Vitro Antimicrobial Susceptibility for Lefamulin (Pleuromutilin) for <i>Ureaplasma</i> Spp. and <i>Mycoplasma hominis</i>
ανά: Oliver Spiller-Boulter, κ.ά.
Έκδοση: (2021-11-01)

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ανά: Chao Li, κ.ά.
Έκδοση: (2021-02-01)

Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity
ανά: Fidel Martínez-Gutiérrez, κ.ά.
Έκδοση: (2010-12-01)

Antibacterial Effect of Zataria multiflora Extract on MRSA
ανά: Maryam Motevasel, κ.ά.
Έκδοση: (2014-11-01)

Potentiation activity of multiple antibacterial agents by Salvianolate from the Chinese medicine Danshen against methicillin-resistant Staphylococcus aureus (MRSA)
ανά: Qing-Qing Liu, κ.ά.
Έκδοση: (2016-05-01)

A Comprehensive Overview of the Antibiotics Approved in the Last Two Decades: Retrospects and Prospects
ανά: Zhenfeng Shi, κ.ά.
Έκδοση: (2023-02-01)

Antibacterial activity of recently approved antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) strains: A systematic review and meta-analysis
ανά: Fei Liu, κ.ά.
Έκδοση: (2022-08-01)

Potency of xanthone derivatives as antibacterial agent against Methicillin-Resistant Staphylococcus Aureus (MRSA)
ανά: Isnatin Miladiyah, κ.ά.
Έκδοση: (2017-06-01)

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ανά: Constantia Lidwina Targanski, κ.ά.
Έκδοση: (2023-07-01)

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ανά: Xinyi Tan, κ.ά.
Έκδοση: (2021-02-01)

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ανά: Piotr Cybulski, κ.ά.
Έκδοση: (2023-10-01)

Lefamulin efficacy and safety in a pooled phase 3 clinical trial population with community-acquired bacterial pneumonia and common clinical comorbidities
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Έκδοση: (2019-05-01)

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Έκδοση: (2022-10-01)

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ανά: Hsu C, κ.ά.
Έκδοση: (2017-11-01)

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Έκδοση: (2021-07-01)