Allogeneic Mesenchymal Stromal Cells Significantly Increase Type 1 Regulatory T Cells, Decrease Effector Th17 Cells, and Decrease Aneurysm Volume in a Dose-dependent Fashion in Patients With Small Abdominal Aortic Aneurysms: Results of the Phase I Aneurysm Repression With Mesenchymal Stromal Cells (the Arrest Trial)
Main Authors: | , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-01-01
|
Series: | JVS - Vascular Science |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2666350323000639 |
_version_ | 1827395206250496000 |
---|---|
author | Humraaz Samra Katherin Leckie Leni Moldovan Kristen Wanczyk Lava Timsina Mithun Sinha Imran Khan Mohammed Ravi Mylvaganam Anush Motaganahalli Paul Territo Ashley Gutwein Raghunandan Motaganahalli Michael P. Murphy |
author_facet | Humraaz Samra Katherin Leckie Leni Moldovan Kristen Wanczyk Lava Timsina Mithun Sinha Imran Khan Mohammed Ravi Mylvaganam Anush Motaganahalli Paul Territo Ashley Gutwein Raghunandan Motaganahalli Michael P. Murphy |
author_sort | Humraaz Samra |
collection | DOAJ |
first_indexed | 2024-03-08T18:29:21Z |
format | Article |
id | doaj.art-08e187218ffc478d81fd15b1a894ca40 |
institution | Directory Open Access Journal |
issn | 2666-3503 |
language | English |
last_indexed | 2024-03-08T18:29:21Z |
publishDate | 2023-01-01 |
publisher | Elsevier |
record_format | Article |
series | JVS - Vascular Science |
spelling | doaj.art-08e187218ffc478d81fd15b1a894ca402023-12-30T04:45:01ZengElsevierJVS - Vascular Science2666-35032023-01-014100159Allogeneic Mesenchymal Stromal Cells Significantly Increase Type 1 Regulatory T Cells, Decrease Effector Th17 Cells, and Decrease Aneurysm Volume in a Dose-dependent Fashion in Patients With Small Abdominal Aortic Aneurysms: Results of the Phase I Aneurysm Repression With Mesenchymal Stromal Cells (the Arrest Trial)Humraaz Samra0Katherin Leckie1Leni Moldovan2Kristen Wanczyk3Lava Timsina4Mithun Sinha5Imran Khan Mohammed6Ravi Mylvaganam7Anush Motaganahalli8Paul Territo9Ashley Gutwein10Raghunandan Motaganahalli11Michael P. Murphy12Indiana University, Indianapolis, INIndiana University, Indianapolis, INIUPUI AND VAMC, Indianapolis, INIUPUI AND VAMC, Indianapolis, INIndiana University, Indianapolis, INIndiana University, Indianapolis, INIndiana University, Indianapolis, INMassachusetts General Hospital, Boston, MAIndiana University, Indianapolis, INIndiana University, Indianapolis, INIndiana University, Indianapolis, INIndiana University, Indianapolis, INIndiana University, Indianapolis, INhttp://www.sciencedirect.com/science/article/pii/S2666350323000639 |
spellingShingle | Humraaz Samra Katherin Leckie Leni Moldovan Kristen Wanczyk Lava Timsina Mithun Sinha Imran Khan Mohammed Ravi Mylvaganam Anush Motaganahalli Paul Territo Ashley Gutwein Raghunandan Motaganahalli Michael P. Murphy Allogeneic Mesenchymal Stromal Cells Significantly Increase Type 1 Regulatory T Cells, Decrease Effector Th17 Cells, and Decrease Aneurysm Volume in a Dose-dependent Fashion in Patients With Small Abdominal Aortic Aneurysms: Results of the Phase I Aneurysm Repression With Mesenchymal Stromal Cells (the Arrest Trial) JVS - Vascular Science |
title | Allogeneic Mesenchymal Stromal Cells Significantly Increase Type 1 Regulatory T Cells, Decrease Effector Th17 Cells, and Decrease Aneurysm Volume in a Dose-dependent Fashion in Patients With Small Abdominal Aortic Aneurysms: Results of the Phase I Aneurysm Repression With Mesenchymal Stromal Cells (the Arrest Trial) |
title_full | Allogeneic Mesenchymal Stromal Cells Significantly Increase Type 1 Regulatory T Cells, Decrease Effector Th17 Cells, and Decrease Aneurysm Volume in a Dose-dependent Fashion in Patients With Small Abdominal Aortic Aneurysms: Results of the Phase I Aneurysm Repression With Mesenchymal Stromal Cells (the Arrest Trial) |
title_fullStr | Allogeneic Mesenchymal Stromal Cells Significantly Increase Type 1 Regulatory T Cells, Decrease Effector Th17 Cells, and Decrease Aneurysm Volume in a Dose-dependent Fashion in Patients With Small Abdominal Aortic Aneurysms: Results of the Phase I Aneurysm Repression With Mesenchymal Stromal Cells (the Arrest Trial) |
title_full_unstemmed | Allogeneic Mesenchymal Stromal Cells Significantly Increase Type 1 Regulatory T Cells, Decrease Effector Th17 Cells, and Decrease Aneurysm Volume in a Dose-dependent Fashion in Patients With Small Abdominal Aortic Aneurysms: Results of the Phase I Aneurysm Repression With Mesenchymal Stromal Cells (the Arrest Trial) |
title_short | Allogeneic Mesenchymal Stromal Cells Significantly Increase Type 1 Regulatory T Cells, Decrease Effector Th17 Cells, and Decrease Aneurysm Volume in a Dose-dependent Fashion in Patients With Small Abdominal Aortic Aneurysms: Results of the Phase I Aneurysm Repression With Mesenchymal Stromal Cells (the Arrest Trial) |
title_sort | allogeneic mesenchymal stromal cells significantly increase type 1 regulatory t cells decrease effector th17 cells and decrease aneurysm volume in a dose dependent fashion in patients with small abdominal aortic aneurysms results of the phase i aneurysm repression with mesenchymal stromal cells the arrest trial |
url | http://www.sciencedirect.com/science/article/pii/S2666350323000639 |
work_keys_str_mv | AT humraazsamra allogeneicmesenchymalstromalcellssignificantlyincreasetype1regulatorytcellsdecreaseeffectorth17cellsanddecreaseaneurysmvolumeinadosedependentfashioninpatientswithsmallabdominalaorticaneurysmsresultsofthephaseianeurysmrepressionwithmesenchymalstromalcellst AT katherinleckie allogeneicmesenchymalstromalcellssignificantlyincreasetype1regulatorytcellsdecreaseeffectorth17cellsanddecreaseaneurysmvolumeinadosedependentfashioninpatientswithsmallabdominalaorticaneurysmsresultsofthephaseianeurysmrepressionwithmesenchymalstromalcellst AT lenimoldovan allogeneicmesenchymalstromalcellssignificantlyincreasetype1regulatorytcellsdecreaseeffectorth17cellsanddecreaseaneurysmvolumeinadosedependentfashioninpatientswithsmallabdominalaorticaneurysmsresultsofthephaseianeurysmrepressionwithmesenchymalstromalcellst AT kristenwanczyk allogeneicmesenchymalstromalcellssignificantlyincreasetype1regulatorytcellsdecreaseeffectorth17cellsanddecreaseaneurysmvolumeinadosedependentfashioninpatientswithsmallabdominalaorticaneurysmsresultsofthephaseianeurysmrepressionwithmesenchymalstromalcellst AT lavatimsina allogeneicmesenchymalstromalcellssignificantlyincreasetype1regulatorytcellsdecreaseeffectorth17cellsanddecreaseaneurysmvolumeinadosedependentfashioninpatientswithsmallabdominalaorticaneurysmsresultsofthephaseianeurysmrepressionwithmesenchymalstromalcellst AT mithunsinha allogeneicmesenchymalstromalcellssignificantlyincreasetype1regulatorytcellsdecreaseeffectorth17cellsanddecreaseaneurysmvolumeinadosedependentfashioninpatientswithsmallabdominalaorticaneurysmsresultsofthephaseianeurysmrepressionwithmesenchymalstromalcellst AT imrankhanmohammed allogeneicmesenchymalstromalcellssignificantlyincreasetype1regulatorytcellsdecreaseeffectorth17cellsanddecreaseaneurysmvolumeinadosedependentfashioninpatientswithsmallabdominalaorticaneurysmsresultsofthephaseianeurysmrepressionwithmesenchymalstromalcellst AT ravimylvaganam allogeneicmesenchymalstromalcellssignificantlyincreasetype1regulatorytcellsdecreaseeffectorth17cellsanddecreaseaneurysmvolumeinadosedependentfashioninpatientswithsmallabdominalaorticaneurysmsresultsofthephaseianeurysmrepressionwithmesenchymalstromalcellst AT anushmotaganahalli allogeneicmesenchymalstromalcellssignificantlyincreasetype1regulatorytcellsdecreaseeffectorth17cellsanddecreaseaneurysmvolumeinadosedependentfashioninpatientswithsmallabdominalaorticaneurysmsresultsofthephaseianeurysmrepressionwithmesenchymalstromalcellst AT paulterrito allogeneicmesenchymalstromalcellssignificantlyincreasetype1regulatorytcellsdecreaseeffectorth17cellsanddecreaseaneurysmvolumeinadosedependentfashioninpatientswithsmallabdominalaorticaneurysmsresultsofthephaseianeurysmrepressionwithmesenchymalstromalcellst AT ashleygutwein allogeneicmesenchymalstromalcellssignificantlyincreasetype1regulatorytcellsdecreaseeffectorth17cellsanddecreaseaneurysmvolumeinadosedependentfashioninpatientswithsmallabdominalaorticaneurysmsresultsofthephaseianeurysmrepressionwithmesenchymalstromalcellst AT raghunandanmotaganahalli allogeneicmesenchymalstromalcellssignificantlyincreasetype1regulatorytcellsdecreaseeffectorth17cellsanddecreaseaneurysmvolumeinadosedependentfashioninpatientswithsmallabdominalaorticaneurysmsresultsofthephaseianeurysmrepressionwithmesenchymalstromalcellst AT michaelpmurphy allogeneicmesenchymalstromalcellssignificantlyincreasetype1regulatorytcellsdecreaseeffectorth17cellsanddecreaseaneurysmvolumeinadosedependentfashioninpatientswithsmallabdominalaorticaneurysmsresultsofthephaseianeurysmrepressionwithmesenchymalstromalcellst |