First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
ABSTRACT Vaccines represent a remarkable success in the history of medicine since they have prevented and, in some instances, eradicated a range of infectious diseases. However, for many existing vaccines, immunogenicity is limited, requiring multiple booster doses, and we are still unable to target...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2018-08-01
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| Series: | mSphere |
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| Online Access: | https://journals.asm.org/doi/10.1128/mSphere.00214-18 |
| _version_ | 1818570132748763136 |
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| author | Francesco Borriello Simon D. van Haren Ofer Levy |
| author_facet | Francesco Borriello Simon D. van Haren Ofer Levy |
| author_sort | Francesco Borriello |
| collection | DOAJ |
| description | ABSTRACT Vaccines represent a remarkable success in the history of medicine since they have prevented and, in some instances, eradicated a range of infectious diseases. However, for many existing vaccines, immunogenicity is limited, requiring multiple booster doses, and we are still unable to target many pathogens due to intrinsic features of the microorganism, such as genetic/antigenic variability between strains, and our limited understanding of the variables that regulate vaccine responsiveness, including age- and sex-specific differences. Moreover, the traditional approach to vaccine development is often empirical, relying on inactivation of microorganisms or purification of their components, which are usually less immunogenic than the whole microorganism from which they derive. This approach has yielded multiple important vaccines but has failed to consistently generate vaccines that are sufficiently immunogenic in populations with limited immune responsiveness such as newborns and elderly individuals. In an effort to trigger impactful collaborations, a community of scientists gathered in Boston in the United States for the first biennial International Precision Vaccines Conference, sponsored by the Boston Children’s Hospital Precision Vaccines Program, to discuss innovation in vaccinology. Recent advancements in the field of systems biology that can identify vaccine immunogenicity biomarkers for target populations, in human in vitro models, and in novel adjuvant and formulation strategies offer unprecedented opportunities to dissect the human immune response to vaccines and inform dramatic improvements in vaccine efficacy. These approaches are poised to have a major scientific and translational impact in vaccinology. |
| first_indexed | 2024-12-14T06:56:40Z |
| format | Article |
| id | doaj.art-08e3624228af4bf1825ba34e635d7fa8 |
| institution | Directory Open Access Journal |
| issn | 2379-5042 |
| language | English |
| last_indexed | 2024-12-14T06:56:40Z |
| publishDate | 2018-08-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mSphere |
| spelling | doaj.art-08e3624228af4bf1825ba34e635d7fa82022-12-21T23:12:37ZengAmerican Society for MicrobiologymSphere2379-50422018-08-013410.1128/mSphere.00214-18First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation VaccinesFrancesco Borriello0Simon D. van Haren1Ofer Levy2Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, USAPrecision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, USAPrecision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, USAABSTRACT Vaccines represent a remarkable success in the history of medicine since they have prevented and, in some instances, eradicated a range of infectious diseases. However, for many existing vaccines, immunogenicity is limited, requiring multiple booster doses, and we are still unable to target many pathogens due to intrinsic features of the microorganism, such as genetic/antigenic variability between strains, and our limited understanding of the variables that regulate vaccine responsiveness, including age- and sex-specific differences. Moreover, the traditional approach to vaccine development is often empirical, relying on inactivation of microorganisms or purification of their components, which are usually less immunogenic than the whole microorganism from which they derive. This approach has yielded multiple important vaccines but has failed to consistently generate vaccines that are sufficiently immunogenic in populations with limited immune responsiveness such as newborns and elderly individuals. In an effort to trigger impactful collaborations, a community of scientists gathered in Boston in the United States for the first biennial International Precision Vaccines Conference, sponsored by the Boston Children’s Hospital Precision Vaccines Program, to discuss innovation in vaccinology. Recent advancements in the field of systems biology that can identify vaccine immunogenicity biomarkers for target populations, in human in vitro models, and in novel adjuvant and formulation strategies offer unprecedented opportunities to dissect the human immune response to vaccines and inform dramatic improvements in vaccine efficacy. These approaches are poised to have a major scientific and translational impact in vaccinology.https://journals.asm.org/doi/10.1128/mSphere.00214-18adjuvantsimmunizationmeeting reportprecision vaccinessystems vaccinology |
| spellingShingle | Francesco Borriello Simon D. van Haren Ofer Levy First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines mSphere adjuvants immunization meeting report precision vaccines systems vaccinology |
| title | First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines |
| title_full | First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines |
| title_fullStr | First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines |
| title_full_unstemmed | First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines |
| title_short | First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines |
| title_sort | first international precision vaccines conference multidisciplinary approaches to next generation vaccines |
| topic | adjuvants immunization meeting report precision vaccines systems vaccinology |
| url | https://journals.asm.org/doi/10.1128/mSphere.00214-18 |
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