Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation

Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation

<p>Abstract</p> <p>Background</p> <p>HIV-1 Nef protein contributes to pathogenesis via multiple functions that include enhancement of viral replication and infectivity, alteration of intracellular trafficking, and modulation of cellular signaling pathways. Nef stimulate...

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Bibliographic Details
Main Authors: Mukerji Joya, Olivieri Kevin C, Misra Vikas, Agopian Kristin A, Gabuzda Dana
Format: Article
Language:English
Published: BMC 2012-06-01
Series:Retrovirology
Subjects:
HIV
Nef
Exocyst complex
Intercellular nanotubes
Pak2 kinase
Fluorescence confocal microscopy
Online Access:http://www.retrovirology.com/content/9/1/33

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