The combination of body mass index and fasting plasma glucose is associated with type 2 diabetes mellitus in Japan: a secondary retrospective analysis
BackgroundBody mass index (BMI) and fasting plasma glucose (FPG) are known risk factors for type 2 diabetes mellitus (T2DM), but data on the prospective association of the combination of BMI and FPG with T2DM are limited. This study sought to characterize the association of the combination of BMI an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1355180/full |
| _version_ | 1797311622862077952 |
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| author | Xiaofang Zhao Tianci Yao Bei Song Haohui Fan Ting Liu Guangyu Gao Kun Wang Weilin Lu Chengyun Liu |
| author_facet | Xiaofang Zhao Tianci Yao Bei Song Haohui Fan Ting Liu Guangyu Gao Kun Wang Weilin Lu Chengyun Liu |
| author_sort | Xiaofang Zhao |
| collection | DOAJ |
| description | BackgroundBody mass index (BMI) and fasting plasma glucose (FPG) are known risk factors for type 2 diabetes mellitus (T2DM), but data on the prospective association of the combination of BMI and FPG with T2DM are limited. This study sought to characterize the association of the combination of BMI and FPG (ByG) with T2DM.MethodsThe current study used the NAGALA database. We categorized participants by tertiles of ByG. The association of ByG with T2DM was expressed with hazard ratios (HRs) with 95% confidence intervals (CIs) after adjustment for potential risk factors.ResultsDuring a median follow-up of 6.19 years in the normoglycemia cohort and 5.58 years in the prediabetes cohort, the incidence of T2DM was 0.75% and 7.79%, respectively. Following multivariable adjustments, there were stepwise increases in T2DM with increasing tertiles of ByG. After a similar multivariable adjustment, the risk of T2DM was 2.57 (95% CI 2.26 - 2.92), 1.97 (95% CI 1.53 - 2.54) and 1.50 (95% CI 1.30 - 1.74) for a per-SD change in ByG in all populations, the normoglycemia cohort and the prediabetes cohort, respectively.ConclusionByG was associated with an increased risk of T2DM in Japan. The result reinforced the importance of the combination of BMI and FPG in assessing T2DM risk. |
| first_indexed | 2024-03-08T02:02:23Z |
| format | Article |
| id | doaj.art-08e52f0ceeed4344b2ca9a7633fdec26 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T02:02:23Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-08e52f0ceeed4344b2ca9a7633fdec262024-02-14T04:53:23ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-02-011510.3389/fendo.2024.13551801355180The combination of body mass index and fasting plasma glucose is associated with type 2 diabetes mellitus in Japan: a secondary retrospective analysisXiaofang ZhaoTianci YaoBei SongHaohui FanTing LiuGuangyu GaoKun WangWeilin LuChengyun LiuBackgroundBody mass index (BMI) and fasting plasma glucose (FPG) are known risk factors for type 2 diabetes mellitus (T2DM), but data on the prospective association of the combination of BMI and FPG with T2DM are limited. This study sought to characterize the association of the combination of BMI and FPG (ByG) with T2DM.MethodsThe current study used the NAGALA database. We categorized participants by tertiles of ByG. The association of ByG with T2DM was expressed with hazard ratios (HRs) with 95% confidence intervals (CIs) after adjustment for potential risk factors.ResultsDuring a median follow-up of 6.19 years in the normoglycemia cohort and 5.58 years in the prediabetes cohort, the incidence of T2DM was 0.75% and 7.79%, respectively. Following multivariable adjustments, there were stepwise increases in T2DM with increasing tertiles of ByG. After a similar multivariable adjustment, the risk of T2DM was 2.57 (95% CI 2.26 - 2.92), 1.97 (95% CI 1.53 - 2.54) and 1.50 (95% CI 1.30 - 1.74) for a per-SD change in ByG in all populations, the normoglycemia cohort and the prediabetes cohort, respectively.ConclusionByG was associated with an increased risk of T2DM in Japan. The result reinforced the importance of the combination of BMI and FPG in assessing T2DM risk.https://www.frontiersin.org/articles/10.3389/fendo.2024.1355180/fulltype 2 diabetes mellitusbody mass indexfasting plasma glucoseinsulin resistanceJapan |
| spellingShingle | Xiaofang Zhao Tianci Yao Bei Song Haohui Fan Ting Liu Guangyu Gao Kun Wang Weilin Lu Chengyun Liu The combination of body mass index and fasting plasma glucose is associated with type 2 diabetes mellitus in Japan: a secondary retrospective analysis Frontiers in Endocrinology type 2 diabetes mellitus body mass index fasting plasma glucose insulin resistance Japan |
| title | The combination of body mass index and fasting plasma glucose is associated with type 2 diabetes mellitus in Japan: a secondary retrospective analysis |
| title_full | The combination of body mass index and fasting plasma glucose is associated with type 2 diabetes mellitus in Japan: a secondary retrospective analysis |
| title_fullStr | The combination of body mass index and fasting plasma glucose is associated with type 2 diabetes mellitus in Japan: a secondary retrospective analysis |
| title_full_unstemmed | The combination of body mass index and fasting plasma glucose is associated with type 2 diabetes mellitus in Japan: a secondary retrospective analysis |
| title_short | The combination of body mass index and fasting plasma glucose is associated with type 2 diabetes mellitus in Japan: a secondary retrospective analysis |
| title_sort | combination of body mass index and fasting plasma glucose is associated with type 2 diabetes mellitus in japan a secondary retrospective analysis |
| topic | type 2 diabetes mellitus body mass index fasting plasma glucose insulin resistance Japan |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1355180/full |
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