Humanized Mouse Models for the Study of Periodontitis: An Opportunity to Elucidate Unresolved Aspects of Its Immunopathogenesis and Analyze New Immunotherapeutic Strategies

Humanized Mouse Models for the Study of Periodontitis: An Opportunity to Elucidate Unresolved Aspects of Its Immunopathogenesis and Analyze New Immunotherapeutic Strategies

Periodontitis is an oral inflammatory disease in which the polymicrobial synergy and dysbiosis of the subgingival microbiota trigger a deregulated host immune response, that leads to the breakdown of tooth-supporting tissues and finally tooth loss. Periodontitis is characterized by the increased pat...

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Bibliographic Details
Main Authors: Carolina Rojas, Michelle P. García, Alan F. Polanco, Luis González-Osuna, Alfredo Sierra-Cristancho, Samanta Melgar-Rodríguez, Emilio A. Cafferata, Rolando Vernal
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
periodontitis
animal model
humanized mice
immunopathogenesis
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.663328/full

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