Vulnerability of Triple-Negative Breast Cancer to Saponin Formosanin C-Induced Ferroptosis

Vulnerability of Triple-Negative Breast Cancer to Saponin Formosanin C-Induced Ferroptosis

Targeting ferritin via autophagy (ferritinophagy) to induce ferroptosis, an iron- and reactive oxygen species (ROS)-dependent cell death, provides novel strategies for cancer therapy. Using a ferroptosis-specific inhibitor and iron chelator, the vulnerability of triple-negative breast cancer (TNBC)...

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Bibliographic Details
Main Authors: Hsin-Chih Chen, Han-Hsuan Tang, Wei-Hsiang Hsu, Shan-Ying Wu, Wen-Hsing Cheng, Bao-Yuan Wang, Chun-Li Su
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Antioxidants
Subjects:
formosanin C
breast cancer
ferroptosis potential index
ferritinophagy
gene database
Online Access:https://www.mdpi.com/2076-3921/11/2/298

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