Dietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysis
Abstract Background Accumulating evidence has suggested that dietary polyphenols may be protective against metabolic syndrome (MetS); however, the available evidence is contradictory. The aim of this meta-analysis was to assess the association between dietary intake of polyphenols and the odds of Me...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-024-01556-x |
| _version_ | 1797274275084763136 |
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| author | Pushpamala Ramaiah Kamilya Jamel Baljon Ahmed Hjazi Maytham T. Qasim Omar Abdulwahid Salih Al-ani Shad Imad Beneen M. Hussien Ali Alsalamy Nazila Garousi |
| author_facet | Pushpamala Ramaiah Kamilya Jamel Baljon Ahmed Hjazi Maytham T. Qasim Omar Abdulwahid Salih Al-ani Shad Imad Beneen M. Hussien Ali Alsalamy Nazila Garousi |
| author_sort | Pushpamala Ramaiah |
| collection | DOAJ |
| description | Abstract Background Accumulating evidence has suggested that dietary polyphenols may be protective against metabolic syndrome (MetS); however, the available evidence is contradictory. The aim of this meta-analysis was to assess the association between dietary intake of polyphenols and the odds of MetS. Methods The PubMed and Scopus databases were systematically searched to obtain eligible studies. The risk of MetS for the highest versus the lowest intakes of total, subclasses and individual polyphenols were examined by pooling odds ratios (OR) and 95% confidence intervals (95%CI) using the random effects model. Results A total of 14 studies (6 cohort and 8 cross-sectional studies) involving a total of 50,366 participants with 10,879 cases of MetS were included. When various polyphenol compounds were pooled, they were significantly related to a 22% decreased odds of MetS (([5 studies]; OR: 0.78; 95%CI: 0.72–0.85). Higher intakes of total flavonoids (([9 studies]; OR: 0.78; 95%CI: 0.72–0.85), flavan-3-ols (([2 studies]; OR: 0.64; 95%CI: 0.43–0.94), isoflavones (([3 studies]; OR: 0.84; 95%CI: 0.75–0.93), stilbenes (([4 studies]; OR: 0.86; 95%CI: 0.76–0.97), flavones (([2 studies]; OR: 0.79; 95%CI: 0.71–0.89), and quercetin (([2 studies]; OR: 0.63; 95%CI: 0.43–0.93) were also significantly associated with a decreased risk of MetS. The associations were not modified by the age of the participants. No association was found for total polyphenols, phenolic acids, lignans, anthocyanins, and flavonols. Conclusion The results of this meta-analysis supported that higher polyphenol intake can lower the risk of MetS. |
| first_indexed | 2024-03-07T14:57:06Z |
| format | Article |
| id | doaj.art-08e6c53db15b45578b5c791cc60ca682 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-03-07T14:57:06Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-08e6c53db15b45578b5c791cc60ca6822024-03-05T19:22:17ZengBMCBMC Endocrine Disorders1472-68232024-03-0124111410.1186/s12902-024-01556-xDietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysisPushpamala Ramaiah0Kamilya Jamel Baljon1Ahmed Hjazi2Maytham T. Qasim3Omar Abdulwahid Salih Al-ani4Shad Imad5Beneen M. Hussien6Ali Alsalamy7Nazila Garousi8Faculty of Nursing, Umm al- Qura UniversityFaculty of Nursing, Umm al- Qura UniversityDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz UniversityDepartment of Anesthesia, College of Health and Medical Technololgy, Al-Ayen UniversityDepartment of Pharmacy, Al Rafidain University CollegeMedical Technical College, Al-Farahidi UniversityMedical Laboratory Technology Department, College of Medical Technology, The Islamic UniversityCollege of medical technology, Imam Ja’afar Al-Sadiq UniversityDepartment of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesAbstract Background Accumulating evidence has suggested that dietary polyphenols may be protective against metabolic syndrome (MetS); however, the available evidence is contradictory. The aim of this meta-analysis was to assess the association between dietary intake of polyphenols and the odds of MetS. Methods The PubMed and Scopus databases were systematically searched to obtain eligible studies. The risk of MetS for the highest versus the lowest intakes of total, subclasses and individual polyphenols were examined by pooling odds ratios (OR) and 95% confidence intervals (95%CI) using the random effects model. Results A total of 14 studies (6 cohort and 8 cross-sectional studies) involving a total of 50,366 participants with 10,879 cases of MetS were included. When various polyphenol compounds were pooled, they were significantly related to a 22% decreased odds of MetS (([5 studies]; OR: 0.78; 95%CI: 0.72–0.85). Higher intakes of total flavonoids (([9 studies]; OR: 0.78; 95%CI: 0.72–0.85), flavan-3-ols (([2 studies]; OR: 0.64; 95%CI: 0.43–0.94), isoflavones (([3 studies]; OR: 0.84; 95%CI: 0.75–0.93), stilbenes (([4 studies]; OR: 0.86; 95%CI: 0.76–0.97), flavones (([2 studies]; OR: 0.79; 95%CI: 0.71–0.89), and quercetin (([2 studies]; OR: 0.63; 95%CI: 0.43–0.93) were also significantly associated with a decreased risk of MetS. The associations were not modified by the age of the participants. No association was found for total polyphenols, phenolic acids, lignans, anthocyanins, and flavonols. Conclusion The results of this meta-analysis supported that higher polyphenol intake can lower the risk of MetS.https://doi.org/10.1186/s12902-024-01556-xMetabolic syndromeFlavonoidsPolyphenolsMeta-analysis |
| spellingShingle | Pushpamala Ramaiah Kamilya Jamel Baljon Ahmed Hjazi Maytham T. Qasim Omar Abdulwahid Salih Al-ani Shad Imad Beneen M. Hussien Ali Alsalamy Nazila Garousi Dietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysis BMC Endocrine Disorders Metabolic syndrome Flavonoids Polyphenols Meta-analysis |
| title | Dietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysis |
| title_full | Dietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysis |
| title_fullStr | Dietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysis |
| title_full_unstemmed | Dietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysis |
| title_short | Dietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysis |
| title_sort | dietary polyphenols and the risk of metabolic syndrome a systematic review and meta analysis |
| topic | Metabolic syndrome Flavonoids Polyphenols Meta-analysis |
| url | https://doi.org/10.1186/s12902-024-01556-x |
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