Polymorphisms in drug-resistant-related genes shared among drug-resistant and pan-susceptible strains of sequence type 10, Beijing family of Mycobacterium tuberculosis
Mutations in genes involved in drug metabolism have been well-associated with drug resistance. Sequence analysis of known antimycobacterial drug-resistant genes is often used to predict resistance to antibiotics. However, some polymorphisms in such genes may serve a phylogenetic purpose rather than...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | International Journal of Mycobacteriology |
| Subjects: | |
| Online Access: | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=1;spage=67;epage=72;aulast=Regmi |
| _version_ | 1818415466396254208 |
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| author | Sanjib Mani Regmi Olabisi Oluwabukola Coker Supasak Kulawonganunchai Sissades Tongsima Therdsak Prammananan Wasna Viratyosin Iyarit Thaipisuttikul Angkana Chaiprasert |
| author_facet | Sanjib Mani Regmi Olabisi Oluwabukola Coker Supasak Kulawonganunchai Sissades Tongsima Therdsak Prammananan Wasna Viratyosin Iyarit Thaipisuttikul Angkana Chaiprasert |
| author_sort | Sanjib Mani Regmi |
| collection | DOAJ |
| description | Mutations in genes involved in drug metabolism have been well-associated with drug resistance. Sequence analysis of known antimycobacterial drug-resistant genes is often used to predict resistance to antibiotics. However, some polymorphisms in such genes may serve a phylogenetic purpose rather than resistance to drugs. The Beijing family of Mycobacterium tuberculosis (MTB) is prevalent worldwide and has been associated with the emergence of multidrug resistance. Sequence type (ST) 10 of the Beijing family is the most predominant in countries like Peru, Taiwan and Thailand.
A sequence analysis was performed of 81 previously reported drug-resistant associated genes in multidrug-resistant and pan-susceptible strains of the Beijing family sequence type 10 of MTB. This analysis revealed 10 synonymous and 12 nonsynonymous single nucleotide polymorphisms (SNPs) that are shared by all strains under study. One frameshift mutation was also observed to be common to all. These data might be useful in excluding some observed SNPs in drug-resistant-associated genes of MTB Beijing ST 10 when performing genotypic drug susceptibility assay. |
| first_indexed | 2024-12-14T11:35:26Z |
| format | Article |
| id | doaj.art-08e74e3717cd4648a390714f8849f423 |
| institution | Directory Open Access Journal |
| issn | 2212-5531 2212-554X |
| language | English |
| last_indexed | 2024-12-14T11:35:26Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Mycobacteriology |
| spelling | doaj.art-08e74e3717cd4648a390714f8849f4232022-12-21T23:03:03ZengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriology2212-55312212-554X2015-01-0141677210.1016/j.ijmyco.2014.11.050Polymorphisms in drug-resistant-related genes shared among drug-resistant and pan-susceptible strains of sequence type 10, Beijing family of Mycobacterium tuberculosisSanjib Mani RegmiOlabisi Oluwabukola CokerSupasak KulawonganunchaiSissades TongsimaTherdsak PrammanananWasna ViratyosinIyarit ThaipisuttikulAngkana ChaiprasertMutations in genes involved in drug metabolism have been well-associated with drug resistance. Sequence analysis of known antimycobacterial drug-resistant genes is often used to predict resistance to antibiotics. However, some polymorphisms in such genes may serve a phylogenetic purpose rather than resistance to drugs. The Beijing family of Mycobacterium tuberculosis (MTB) is prevalent worldwide and has been associated with the emergence of multidrug resistance. Sequence type (ST) 10 of the Beijing family is the most predominant in countries like Peru, Taiwan and Thailand. A sequence analysis was performed of 81 previously reported drug-resistant associated genes in multidrug-resistant and pan-susceptible strains of the Beijing family sequence type 10 of MTB. This analysis revealed 10 synonymous and 12 nonsynonymous single nucleotide polymorphisms (SNPs) that are shared by all strains under study. One frameshift mutation was also observed to be common to all. These data might be useful in excluding some observed SNPs in drug-resistant-associated genes of MTB Beijing ST 10 when performing genotypic drug susceptibility assay.http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=1;spage=67;epage=72;aulast=RegmiPolymorphismDrug-resistant-related genesMycobacterium tuberculosisSequence type 10Beijing family |
| spellingShingle | Sanjib Mani Regmi Olabisi Oluwabukola Coker Supasak Kulawonganunchai Sissades Tongsima Therdsak Prammananan Wasna Viratyosin Iyarit Thaipisuttikul Angkana Chaiprasert Polymorphisms in drug-resistant-related genes shared among drug-resistant and pan-susceptible strains of sequence type 10, Beijing family of Mycobacterium tuberculosis International Journal of Mycobacteriology Polymorphism Drug-resistant-related genes Mycobacterium tuberculosis Sequence type 10 Beijing family |
| title | Polymorphisms in drug-resistant-related genes shared among drug-resistant and pan-susceptible strains of sequence type 10, Beijing family of Mycobacterium tuberculosis |
| title_full | Polymorphisms in drug-resistant-related genes shared among drug-resistant and pan-susceptible strains of sequence type 10, Beijing family of Mycobacterium tuberculosis |
| title_fullStr | Polymorphisms in drug-resistant-related genes shared among drug-resistant and pan-susceptible strains of sequence type 10, Beijing family of Mycobacterium tuberculosis |
| title_full_unstemmed | Polymorphisms in drug-resistant-related genes shared among drug-resistant and pan-susceptible strains of sequence type 10, Beijing family of Mycobacterium tuberculosis |
| title_short | Polymorphisms in drug-resistant-related genes shared among drug-resistant and pan-susceptible strains of sequence type 10, Beijing family of Mycobacterium tuberculosis |
| title_sort | polymorphisms in drug resistant related genes shared among drug resistant and pan susceptible strains of sequence type 10 beijing family of mycobacterium tuberculosis |
| topic | Polymorphism Drug-resistant-related genes Mycobacterium tuberculosis Sequence type 10 Beijing family |
| url | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=1;spage=67;epage=72;aulast=Regmi |
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