Natural molecules as promising players against diabetic peripheral neuropathy: an emerging nutraceutical approach
ABSTRACTDiabetic peripheral neuropathy is one of the most prevalent complications of diabetes mellitus. It is the most common type of neuropathy characterized by decreased sensory functions in the lower extremities and substantial neuropathic pain. Based on clinical characterization, it is classifie...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-09-01
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| Series: | International Journal of Food Properties |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10942912.2023.2189569 |
| _version_ | 1797202440269856768 |
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| author | Rabia Akram Haseeb Anwar Muhammad Shahid Javed Ali Imran Azhar Rasul Shoaib Ahmad Malik Mobina Manzoor Fakhar Islam Ikram Ullah Khan Faiqa Sajid Tehreem Iman Muhammad Ajmal Shah Tao Sun Ghulam Hussain Mohd Asif Shah |
| author_facet | Rabia Akram Haseeb Anwar Muhammad Shahid Javed Ali Imran Azhar Rasul Shoaib Ahmad Malik Mobina Manzoor Fakhar Islam Ikram Ullah Khan Faiqa Sajid Tehreem Iman Muhammad Ajmal Shah Tao Sun Ghulam Hussain Mohd Asif Shah |
| author_sort | Rabia Akram |
| collection | DOAJ |
| description | ABSTRACTDiabetic peripheral neuropathy is one of the most prevalent complications of diabetes mellitus. It is the most common type of neuropathy characterized by decreased sensory functions in the lower extremities and substantial neuropathic pain. Based on clinical characterization, it is classified into symmetric and asymmetric neuropathy. The pathological changes and neuronal function impairment during diabetes are associated with various pathways, including polyol pathway activation, advanced glycation end-products formation, oxidative stress, protein kinase C activation, poly ADP-ribose polymerase, and hexosamine pathways. Demyelination, axonal atrophy, nerve fibre loss, reduced regeneration, and loss of neurovascular interactions are hallmarks. Although some symptomatic and supportive therapies, such as tricyclic agents, antiarrhythmics, opioid analgesics, incretin, aldose reductase, and protein kinase C inhibitors, are in practice, the outcome is not promising. To fill this gap, natural product-based therapy can prove prodigious as an effective alternative. This review aims to comprehend the available literature on the role of various biological molecules in ameliorating diabetic peripheral neuropathy. These molecules play a key role in reducing oxidative-nitrosative stress, aldose reductase activity, and neuronal apoptosis. They control glucose and HbA1c% levels and improve nerve conduction velocity, axonal regeneration, and antioxidant species (catalase, superoxide dismutase, malondialdehyde). They are known for their attenuating thermal and mechanical hyperalgesia and tactile allodynia. Therefore, there is a need to evaluate these molecules at the pre-clinical and clinical levels for efficacy. Hence, natural molecules may act as promising players against diabetic peripheral neuropathy and are a ray of hope for suffering individuals. |
| first_indexed | 2024-03-11T18:19:46Z |
| format | Article |
| id | doaj.art-08e7f81e94d248109c3e6055316f0a8f |
| institution | Directory Open Access Journal |
| issn | 1094-2912 1532-2386 |
| language | English |
| last_indexed | 2024-04-24T08:03:28Z |
| publishDate | 2023-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Food Properties |
| spelling | doaj.art-08e7f81e94d248109c3e6055316f0a8f2024-04-17T13:20:13ZengTaylor & Francis GroupInternational Journal of Food Properties1094-29121532-23862023-09-0126189491410.1080/10942912.2023.2189569Natural molecules as promising players against diabetic peripheral neuropathy: an emerging nutraceutical approachRabia Akram0Haseeb Anwar1Muhammad Shahid Javed2Ali Imran3Azhar Rasul4Shoaib Ahmad Malik5Mobina Manzoor6Fakhar Islam7Ikram Ullah Khan8Faiqa Sajid9Tehreem Iman10Muhammad Ajmal Shah11Tao Sun12Ghulam Hussain13Mohd Asif Shah14Neurochemicalbiology and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad, PakistanNeurochemicalbiology and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad, PakistanDepartment of Physiology, Sargodha Medical College, Sargodhakebri Dehar, PakistanDepartment of Food Sciences, Government College University, Faisalabad, PakistanDepartment of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, PakistanDepartment of Biochemistry, Sargodha Medical College, Sargodha, PakistanInstitute of Pharmacy, Lahore College for Women University, Lahore, PakistanDepartment of Food Sciences, Government College University, Faisalabad, PakistanDepartment of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, PakistanNeurochemicalbiology and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad, PakistanNeurochemicalbiology and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad, PakistanDepartment of Pharmacy, Hazara University, Mansehra, PakistanCenter for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, Fujian Province, ChinaNeurochemicalbiology and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad, PakistanDepartment of Economics, Kebri Dehar University, Kebri Dehar, EthiopiaABSTRACTDiabetic peripheral neuropathy is one of the most prevalent complications of diabetes mellitus. It is the most common type of neuropathy characterized by decreased sensory functions in the lower extremities and substantial neuropathic pain. Based on clinical characterization, it is classified into symmetric and asymmetric neuropathy. The pathological changes and neuronal function impairment during diabetes are associated with various pathways, including polyol pathway activation, advanced glycation end-products formation, oxidative stress, protein kinase C activation, poly ADP-ribose polymerase, and hexosamine pathways. Demyelination, axonal atrophy, nerve fibre loss, reduced regeneration, and loss of neurovascular interactions are hallmarks. Although some symptomatic and supportive therapies, such as tricyclic agents, antiarrhythmics, opioid analgesics, incretin, aldose reductase, and protein kinase C inhibitors, are in practice, the outcome is not promising. To fill this gap, natural product-based therapy can prove prodigious as an effective alternative. This review aims to comprehend the available literature on the role of various biological molecules in ameliorating diabetic peripheral neuropathy. These molecules play a key role in reducing oxidative-nitrosative stress, aldose reductase activity, and neuronal apoptosis. They control glucose and HbA1c% levels and improve nerve conduction velocity, axonal regeneration, and antioxidant species (catalase, superoxide dismutase, malondialdehyde). They are known for their attenuating thermal and mechanical hyperalgesia and tactile allodynia. Therefore, there is a need to evaluate these molecules at the pre-clinical and clinical levels for efficacy. Hence, natural molecules may act as promising players against diabetic peripheral neuropathy and are a ray of hope for suffering individuals.https://www.tandfonline.com/doi/10.1080/10942912.2023.2189569Diabetesperipheral neuropathyaldose reductaseregenerationnatural molecules |
| spellingShingle | Rabia Akram Haseeb Anwar Muhammad Shahid Javed Ali Imran Azhar Rasul Shoaib Ahmad Malik Mobina Manzoor Fakhar Islam Ikram Ullah Khan Faiqa Sajid Tehreem Iman Muhammad Ajmal Shah Tao Sun Ghulam Hussain Mohd Asif Shah Natural molecules as promising players against diabetic peripheral neuropathy: an emerging nutraceutical approach International Journal of Food Properties Diabetes peripheral neuropathy aldose reductase regeneration natural molecules |
| title | Natural molecules as promising players against diabetic peripheral neuropathy: an emerging nutraceutical approach |
| title_full | Natural molecules as promising players against diabetic peripheral neuropathy: an emerging nutraceutical approach |
| title_fullStr | Natural molecules as promising players against diabetic peripheral neuropathy: an emerging nutraceutical approach |
| title_full_unstemmed | Natural molecules as promising players against diabetic peripheral neuropathy: an emerging nutraceutical approach |
| title_short | Natural molecules as promising players against diabetic peripheral neuropathy: an emerging nutraceutical approach |
| title_sort | natural molecules as promising players against diabetic peripheral neuropathy an emerging nutraceutical approach |
| topic | Diabetes peripheral neuropathy aldose reductase regeneration natural molecules |
| url | https://www.tandfonline.com/doi/10.1080/10942912.2023.2189569 |
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