The Impact of Advanced Maternal Age on Pregnancy Outcomes: A Retrospective Multicenter Study
The aim of this multicenter retrospective cohort study was to examine the impact of maternal age on perinatal outcomes in multiparas, stratified according to maternal age in one- and two-year increments. The analysis involved 302,484 multiparas who delivered between the years 2003 and 2021 in four u...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/17/5696 |
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| author | Hila Hochler Michal Lipschuetz Yael Suissa-Cohen Ari Weiss Hen Y. Sela Simcha Yagel Joshua I. Rosenbloom Sorina Grisaru-Granovsky Misgav Rottenstreich |
| author_facet | Hila Hochler Michal Lipschuetz Yael Suissa-Cohen Ari Weiss Hen Y. Sela Simcha Yagel Joshua I. Rosenbloom Sorina Grisaru-Granovsky Misgav Rottenstreich |
| author_sort | Hila Hochler |
| collection | DOAJ |
| description | The aim of this multicenter retrospective cohort study was to examine the impact of maternal age on perinatal outcomes in multiparas, stratified according to maternal age in one- and two-year increments. The analysis involved 302,484 multiparas who delivered between the years 2003 and 2021 in four university-affiliated obstetrics departments. Maternal age was considered both as a continuous variable and in two-year intervals, as compared with a comparison group of parturients aged 25–30 years. The study focused on cesarean delivery and neonatal intensive care unit (NICU) admission as primary outcomes. The findings revealed that cesarean delivery rates increased as maternal age advanced, with rates ranging from 6.7% among 25–30 year olds, rising continuously from 13.5% to 19.9% between the age strata of 31 and 42, to exceeding 20% among those aged ≥ 43 years (<i>p</i> < 0.01 for each stratum when compared to 25–30 year old group). Similarly, NICU admission rates rose from 2.7% in the comparison group to 6% in parturients aged 45–46 years (<i>p</i> < 0.01 for each stratum when compared to 25–30 year old group). The study highlights the association between incrementally advanced maternal age and increased rates of maternal and neonatal complications, necessitating global awareness of these implications for family planning decisions and maternal care. |
| first_indexed | 2024-03-10T23:19:07Z |
| format | Article |
| id | doaj.art-08e80cc51273434298fcd1b15ef70ba1 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T23:19:07Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-08e80cc51273434298fcd1b15ef70ba12023-11-19T08:24:07ZengMDPI AGJournal of Clinical Medicine2077-03832023-09-011217569610.3390/jcm12175696The Impact of Advanced Maternal Age on Pregnancy Outcomes: A Retrospective Multicenter StudyHila Hochler0Michal Lipschuetz1Yael Suissa-Cohen2Ari Weiss3Hen Y. Sela4Simcha Yagel5Joshua I. Rosenbloom6Sorina Grisaru-Granovsky7Misgav Rottenstreich8Department of Obstetrics and Gynecology, Hadassah Medical Center Mount-Scopus, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9765422, IsraelDepartment of Obstetrics and Gynecology, Hadassah Medical Center Mount-Scopus, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9765422, IsraelDepartment of Obstetrics and Gynecology, Hadassah Medical Center Mount-Scopus, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9765422, IsraelDepartment of Obstetrics & Gynecology, Shaare Zedek Medical Center, Faculty of Medicine, Affiliated with the Hebrew University School of Medicine, Jerusalem 91031, IsraelDepartment of Obstetrics & Gynecology, Shaare Zedek Medical Center, Faculty of Medicine, Affiliated with the Hebrew University School of Medicine, Jerusalem 91031, IsraelDepartment of Obstetrics and Gynecology, Hadassah Medical Center Mount-Scopus, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9765422, IsraelDepartment of Obstetrics and Gynecology, Hadassah Medical Center Ein-Kerem, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91121, IsraelDepartment of Obstetrics & Gynecology, Shaare Zedek Medical Center, Faculty of Medicine, Affiliated with the Hebrew University School of Medicine, Jerusalem 91031, IsraelDepartment of Obstetrics & Gynecology, Shaare Zedek Medical Center, Faculty of Medicine, Affiliated with the Hebrew University School of Medicine, Jerusalem 91031, IsraelThe aim of this multicenter retrospective cohort study was to examine the impact of maternal age on perinatal outcomes in multiparas, stratified according to maternal age in one- and two-year increments. The analysis involved 302,484 multiparas who delivered between the years 2003 and 2021 in four university-affiliated obstetrics departments. Maternal age was considered both as a continuous variable and in two-year intervals, as compared with a comparison group of parturients aged 25–30 years. The study focused on cesarean delivery and neonatal intensive care unit (NICU) admission as primary outcomes. The findings revealed that cesarean delivery rates increased as maternal age advanced, with rates ranging from 6.7% among 25–30 year olds, rising continuously from 13.5% to 19.9% between the age strata of 31 and 42, to exceeding 20% among those aged ≥ 43 years (<i>p</i> < 0.01 for each stratum when compared to 25–30 year old group). Similarly, NICU admission rates rose from 2.7% in the comparison group to 6% in parturients aged 45–46 years (<i>p</i> < 0.01 for each stratum when compared to 25–30 year old group). The study highlights the association between incrementally advanced maternal age and increased rates of maternal and neonatal complications, necessitating global awareness of these implications for family planning decisions and maternal care.https://www.mdpi.com/2077-0383/12/17/5696advanced maternal ageperinatal outcomescesarean deliverypreterm deliveryNICU admissionneonatal asphyxia |
| spellingShingle | Hila Hochler Michal Lipschuetz Yael Suissa-Cohen Ari Weiss Hen Y. Sela Simcha Yagel Joshua I. Rosenbloom Sorina Grisaru-Granovsky Misgav Rottenstreich The Impact of Advanced Maternal Age on Pregnancy Outcomes: A Retrospective Multicenter Study Journal of Clinical Medicine advanced maternal age perinatal outcomes cesarean delivery preterm delivery NICU admission neonatal asphyxia |
| title | The Impact of Advanced Maternal Age on Pregnancy Outcomes: A Retrospective Multicenter Study |
| title_full | The Impact of Advanced Maternal Age on Pregnancy Outcomes: A Retrospective Multicenter Study |
| title_fullStr | The Impact of Advanced Maternal Age on Pregnancy Outcomes: A Retrospective Multicenter Study |
| title_full_unstemmed | The Impact of Advanced Maternal Age on Pregnancy Outcomes: A Retrospective Multicenter Study |
| title_short | The Impact of Advanced Maternal Age on Pregnancy Outcomes: A Retrospective Multicenter Study |
| title_sort | impact of advanced maternal age on pregnancy outcomes a retrospective multicenter study |
| topic | advanced maternal age perinatal outcomes cesarean delivery preterm delivery NICU admission neonatal asphyxia |
| url | https://www.mdpi.com/2077-0383/12/17/5696 |
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