Enhanced Design of Gold Catalysts for Bioorthogonal Polyzymes
Bioorthogonal chemistry introduces nonbiogenic reactions that can be performed in biological systems, allowing for the localized release of therapeutic agents. Bioorthogonal catalysts can amplify uncaging reactions for the in situ generation of therapeutics. Embedding these catalysts into a polymeri...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/15/18/6487 |
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| author | Cristina-Maria Hirschbiegel Stefano Fedeli Xianzhi Zhang Rui Huang Jungmi Park Yisheng Xu Vincent M. Rotello |
| author_facet | Cristina-Maria Hirschbiegel Stefano Fedeli Xianzhi Zhang Rui Huang Jungmi Park Yisheng Xu Vincent M. Rotello |
| author_sort | Cristina-Maria Hirschbiegel |
| collection | DOAJ |
| description | Bioorthogonal chemistry introduces nonbiogenic reactions that can be performed in biological systems, allowing for the localized release of therapeutic agents. Bioorthogonal catalysts can amplify uncaging reactions for the in situ generation of therapeutics. Embedding these catalysts into a polymeric nanoscaffold can protect and modulate the catalytic activity, improving the performance of the resulting bioorthogonal “polyzymes”. Catalysts based on nontoxic metals such as gold(I) are particularly attractive for therapeutic applications. Herein, we optimized the structural components of a metal catalyst to develop an efficient gold(I)-based polyzyme. Tailoring the ligand structure of gold phosphine-based complexes, we improved the affinity between the metal complex and polymer scaffold, resulting in enhanced encapsulation efficiency and catalytic rate of the polyzyme. Our findings show the dependence of the overall polyzyme properties on the structural properties of the encapsulated metal complex. |
| first_indexed | 2024-03-09T23:16:15Z |
| format | Article |
| id | doaj.art-08e8be729da1441892ecfd6216315220 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-09T23:16:15Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-08e8be729da1441892ecfd62163152202023-11-23T17:34:27ZengMDPI AGMaterials1996-19442022-09-011518648710.3390/ma15186487Enhanced Design of Gold Catalysts for Bioorthogonal PolyzymesCristina-Maria Hirschbiegel0Stefano Fedeli1Xianzhi Zhang2Rui Huang3Jungmi Park4Yisheng Xu5Vincent M. Rotello6Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USADepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USADepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USADepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USADepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USAState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USABioorthogonal chemistry introduces nonbiogenic reactions that can be performed in biological systems, allowing for the localized release of therapeutic agents. Bioorthogonal catalysts can amplify uncaging reactions for the in situ generation of therapeutics. Embedding these catalysts into a polymeric nanoscaffold can protect and modulate the catalytic activity, improving the performance of the resulting bioorthogonal “polyzymes”. Catalysts based on nontoxic metals such as gold(I) are particularly attractive for therapeutic applications. Herein, we optimized the structural components of a metal catalyst to develop an efficient gold(I)-based polyzyme. Tailoring the ligand structure of gold phosphine-based complexes, we improved the affinity between the metal complex and polymer scaffold, resulting in enhanced encapsulation efficiency and catalytic rate of the polyzyme. Our findings show the dependence of the overall polyzyme properties on the structural properties of the encapsulated metal complex.https://www.mdpi.com/1996-1944/15/18/6487bioorthogonal catalysisgold catalystspolymeric nanoparticlescatalyst design |
| spellingShingle | Cristina-Maria Hirschbiegel Stefano Fedeli Xianzhi Zhang Rui Huang Jungmi Park Yisheng Xu Vincent M. Rotello Enhanced Design of Gold Catalysts for Bioorthogonal Polyzymes Materials bioorthogonal catalysis gold catalysts polymeric nanoparticles catalyst design |
| title | Enhanced Design of Gold Catalysts for Bioorthogonal Polyzymes |
| title_full | Enhanced Design of Gold Catalysts for Bioorthogonal Polyzymes |
| title_fullStr | Enhanced Design of Gold Catalysts for Bioorthogonal Polyzymes |
| title_full_unstemmed | Enhanced Design of Gold Catalysts for Bioorthogonal Polyzymes |
| title_short | Enhanced Design of Gold Catalysts for Bioorthogonal Polyzymes |
| title_sort | enhanced design of gold catalysts for bioorthogonal polyzymes |
| topic | bioorthogonal catalysis gold catalysts polymeric nanoparticles catalyst design |
| url | https://www.mdpi.com/1996-1944/15/18/6487 |
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