Role of Surgery in Patients with Stage IE Primary Thyroid MALT Lymphoma Staged by a Modified Classification System: The Tokyo Classification
Purposes: To establish the appropriate staging system and assess the role of curative thyroidectomy alone (Surgery) vs. involved-site radiation therapy after open biopsy (OB-ISRT) in stage IE mucosa-associated lymphoid tissue (MALT) lymphoma. Methods: We examined the Tokyo Classification as a modifi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/5/1451 |
| _version_ | 1797615628108955648 |
|---|---|
| author | Yoshiyuki Saito Natsuko Watanabe Nami Suzuki Naoko Saito Hiroto Narimatsu Hiroshi Takami Kaori Kameyama Kana Yoshioka Chie Masaki Junko Akaishi Kiyomi Yamada Hames Masako Matsumoto Miho Fukushita Ai Yoshihara Ritsuko Okamura Chisato Tomoda Akifumi Suzuki Kenichi Matsuzu Wataru Kitagawa Mitsuji Nagahama Jaeduk Yoshimura Noh Kiminori Sugino Koichi Ito |
| author_facet | Yoshiyuki Saito Natsuko Watanabe Nami Suzuki Naoko Saito Hiroto Narimatsu Hiroshi Takami Kaori Kameyama Kana Yoshioka Chie Masaki Junko Akaishi Kiyomi Yamada Hames Masako Matsumoto Miho Fukushita Ai Yoshihara Ritsuko Okamura Chisato Tomoda Akifumi Suzuki Kenichi Matsuzu Wataru Kitagawa Mitsuji Nagahama Jaeduk Yoshimura Noh Kiminori Sugino Koichi Ito |
| author_sort | Yoshiyuki Saito |
| collection | DOAJ |
| description | Purposes: To establish the appropriate staging system and assess the role of curative thyroidectomy alone (Surgery) vs. involved-site radiation therapy after open biopsy (OB-ISRT) in stage IE mucosa-associated lymphoid tissue (MALT) lymphoma. Methods: We examined the Tokyo Classification as a modified classification. This retrospective cohort study included 256 patients with thyroid MALT lymphoma; 137 underwent standard therapy (i.e., OB-ISRT) and were enrolled for the Tokyo classification. Sixty stage IE patients with the same diagnosis were examined to compare Surgery with OB-ISRT. Results: Overall survival (<i>p</i> = 0.0092) and relapse-free survival (0.00113) were significantly better in stage IE vs. stage IIE under the Tokyo classification. No OB-ISRT and Surgery patients died, but three OB-ISRT patients relapsed. The incidence of permanent complications was 28% in OB-ISRT (mainly dry mouth) and 0% in Surgery (<i>p</i> = 0.027). The number of painkiller prescription days was significantly greater in OB-ISRT (<i>p</i> < 0.001). During follow-up, the rate of the new appearance/change of the low-density area in the thyroid gland was significantly higher in OB-ISRT (<i>p</i> = 0.031). Conclusions: The Tokyo classification allows an appropriate discrimination between stages IE and IIE MALT lymphoma. Surgery can provide a good prognosis in stage IE cases; it also avoids complications, shortens painful periods during treatment, and simplifies ultrasound follow-up. |
| first_indexed | 2024-03-11T07:29:22Z |
| format | Article |
| id | doaj.art-08ea67b47eb94ea4934da1e3b39d351d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T07:29:22Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-08ea67b47eb94ea4934da1e3b39d351d2023-11-17T07:24:17ZengMDPI AGCancers2072-66942023-02-01155145110.3390/cancers15051451Role of Surgery in Patients with Stage IE Primary Thyroid MALT Lymphoma Staged by a Modified Classification System: The Tokyo ClassificationYoshiyuki Saito0Natsuko Watanabe1Nami Suzuki2Naoko Saito3Hiroto Narimatsu4Hiroshi Takami5Kaori Kameyama6Kana Yoshioka7Chie Masaki8Junko Akaishi9Kiyomi Yamada Hames10Masako Matsumoto11Miho Fukushita12Ai Yoshihara13Ritsuko Okamura14Chisato Tomoda15Akifumi Suzuki16Kenichi Matsuzu17Wataru Kitagawa18Mitsuji Nagahama19Jaeduk Yoshimura Noh20Kiminori Sugino21Koichi Ito22Department of Surgery, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Radiology, Juntendo University, Tokyo 113-8431, JapanCancer Prevention and Control Division, Kanagawa Cancer Center, Yokohama 241-8515, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanDepartment of Pathology, Showa University Northern Yokohama Hospital, Yokohama 224-8503, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanDepartment of Internal Medicine, Ito Hospital, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, Tokyo 150-8308, JapanPurposes: To establish the appropriate staging system and assess the role of curative thyroidectomy alone (Surgery) vs. involved-site radiation therapy after open biopsy (OB-ISRT) in stage IE mucosa-associated lymphoid tissue (MALT) lymphoma. Methods: We examined the Tokyo Classification as a modified classification. This retrospective cohort study included 256 patients with thyroid MALT lymphoma; 137 underwent standard therapy (i.e., OB-ISRT) and were enrolled for the Tokyo classification. Sixty stage IE patients with the same diagnosis were examined to compare Surgery with OB-ISRT. Results: Overall survival (<i>p</i> = 0.0092) and relapse-free survival (0.00113) were significantly better in stage IE vs. stage IIE under the Tokyo classification. No OB-ISRT and Surgery patients died, but three OB-ISRT patients relapsed. The incidence of permanent complications was 28% in OB-ISRT (mainly dry mouth) and 0% in Surgery (<i>p</i> = 0.027). The number of painkiller prescription days was significantly greater in OB-ISRT (<i>p</i> < 0.001). During follow-up, the rate of the new appearance/change of the low-density area in the thyroid gland was significantly higher in OB-ISRT (<i>p</i> = 0.031). Conclusions: The Tokyo classification allows an appropriate discrimination between stages IE and IIE MALT lymphoma. Surgery can provide a good prognosis in stage IE cases; it also avoids complications, shortens painful periods during treatment, and simplifies ultrasound follow-up.https://www.mdpi.com/2072-6694/15/5/1451mucosa-associated lymphoid tissue lymphomaprimary thyroid lymphomainvolved-site radiation therapythyroidectomy |
| spellingShingle | Yoshiyuki Saito Natsuko Watanabe Nami Suzuki Naoko Saito Hiroto Narimatsu Hiroshi Takami Kaori Kameyama Kana Yoshioka Chie Masaki Junko Akaishi Kiyomi Yamada Hames Masako Matsumoto Miho Fukushita Ai Yoshihara Ritsuko Okamura Chisato Tomoda Akifumi Suzuki Kenichi Matsuzu Wataru Kitagawa Mitsuji Nagahama Jaeduk Yoshimura Noh Kiminori Sugino Koichi Ito Role of Surgery in Patients with Stage IE Primary Thyroid MALT Lymphoma Staged by a Modified Classification System: The Tokyo Classification Cancers mucosa-associated lymphoid tissue lymphoma primary thyroid lymphoma involved-site radiation therapy thyroidectomy |
| title | Role of Surgery in Patients with Stage IE Primary Thyroid MALT Lymphoma Staged by a Modified Classification System: The Tokyo Classification |
| title_full | Role of Surgery in Patients with Stage IE Primary Thyroid MALT Lymphoma Staged by a Modified Classification System: The Tokyo Classification |
| title_fullStr | Role of Surgery in Patients with Stage IE Primary Thyroid MALT Lymphoma Staged by a Modified Classification System: The Tokyo Classification |
| title_full_unstemmed | Role of Surgery in Patients with Stage IE Primary Thyroid MALT Lymphoma Staged by a Modified Classification System: The Tokyo Classification |
| title_short | Role of Surgery in Patients with Stage IE Primary Thyroid MALT Lymphoma Staged by a Modified Classification System: The Tokyo Classification |
| title_sort | role of surgery in patients with stage ie primary thyroid malt lymphoma staged by a modified classification system the tokyo classification |
| topic | mucosa-associated lymphoid tissue lymphoma primary thyroid lymphoma involved-site radiation therapy thyroidectomy |
| url | https://www.mdpi.com/2072-6694/15/5/1451 |
| work_keys_str_mv | AT yoshiyukisaito roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT natsukowatanabe roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT namisuzuki roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT naokosaito roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT hirotonarimatsu roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT hiroshitakami roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT kaorikameyama roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT kanayoshioka roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT chiemasaki roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT junkoakaishi roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT kiyomiyamadahames roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT masakomatsumoto roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT mihofukushita roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT aiyoshihara roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT ritsukookamura roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT chisatotomoda roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT akifumisuzuki roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT kenichimatsuzu roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT watarukitagawa roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT mitsujinagahama roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT jaedukyoshimuranoh roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT kiminorisugino roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification AT koichiito roleofsurgeryinpatientswithstageieprimarythyroidmaltlymphomastagedbyamodifiedclassificationsystemthetokyoclassification |