HYPOGLYCEMIA IN SICK PRETERM INFANTS AND THE THERAPEUTIC EFFECT OF 12.5% DEXTROSE IN WATER COMPARED WITH 10% DEXTROSE IN WATER
Neonatal hypoglycemia is common and its prompt management is important to reduce neurological sequelae. To determine the effect of two different glucose concentrations of intravenous (IV) fluid therapy in the incidence of hypoglycemia in sick premature infants, 200 preterm infants weighing 1500-2...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2005-06-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/2989 |
| _version_ | 1818059282630836224 |
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| author | F. Nili M. Ghafuri |
| author_facet | F. Nili M. Ghafuri |
| author_sort | F. Nili M. Ghafuri |
| collection | DOAJ |
| description | Neonatal hypoglycemia is common and its prompt management is important to reduce neurological sequelae. To determine the effect of two different glucose concentrations of intravenous (IV) fluid therapy in the incidence of hypoglycemia in sick premature infants, 200 preterm infants weighing 1500-2500 g were selected and randomly assigned into two groups. Group 1 received 10% dextrose in water (DW) and for group 2 we used 12.5% DW with recommended fluid volume according to the infant’s condition. First blood glucose sample was obtained during 2-3 hours of life before starting IV therapy and the two others were measured between 4-24 hours of life after starting IV fluid therapy. Plasma glucose < 36 mg/dl during 2-3 hours of life and level below 45 mg/dl between 4-24 hours of life were considered as hypoglycemia. Birth weight, gestational age and type of diseases in two groups were matched. Although there was no difference between volume of fluid, statistical differences were found to be significant between amounts of calories (P = 0.000) and dextrose (P = 0.000) received in two groups. We detected 15 and 30 cases of hypoglycemia in group 1 and 2, respectively. After starting IV fluid therapy, the incidence of hypoglycemia decreased especially in group 2 and comparison of cases with two consecutive low plasma glucose in two groups showed significant difference (P= 0.024, relative risk= 2.67). We recommend 12.5% DW when initiation of peripheral IV therapy is indicated in sick preterm infants weighing 1500-2500 g, especially when restriction of fluid is mandated. |
| first_indexed | 2024-12-10T13:14:03Z |
| format | Article |
| id | doaj.art-08ebabd7c8c742f0b49da61b71273ef9 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-10T13:14:03Z |
| publishDate | 2005-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-08ebabd7c8c742f0b49da61b71273ef92022-12-22T01:47:36ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942005-06-01433HYPOGLYCEMIA IN SICK PRETERM INFANTS AND THE THERAPEUTIC EFFECT OF 12.5% DEXTROSE IN WATER COMPARED WITH 10% DEXTROSE IN WATER F. Nili M. Ghafuri0 Neonatal hypoglycemia is common and its prompt management is important to reduce neurological sequelae. To determine the effect of two different glucose concentrations of intravenous (IV) fluid therapy in the incidence of hypoglycemia in sick premature infants, 200 preterm infants weighing 1500-2500 g were selected and randomly assigned into two groups. Group 1 received 10% dextrose in water (DW) and for group 2 we used 12.5% DW with recommended fluid volume according to the infant’s condition. First blood glucose sample was obtained during 2-3 hours of life before starting IV therapy and the two others were measured between 4-24 hours of life after starting IV fluid therapy. Plasma glucose < 36 mg/dl during 2-3 hours of life and level below 45 mg/dl between 4-24 hours of life were considered as hypoglycemia. Birth weight, gestational age and type of diseases in two groups were matched. Although there was no difference between volume of fluid, statistical differences were found to be significant between amounts of calories (P = 0.000) and dextrose (P = 0.000) received in two groups. We detected 15 and 30 cases of hypoglycemia in group 1 and 2, respectively. After starting IV fluid therapy, the incidence of hypoglycemia decreased especially in group 2 and comparison of cases with two consecutive low plasma glucose in two groups showed significant difference (P= 0.024, relative risk= 2.67). We recommend 12.5% DW when initiation of peripheral IV therapy is indicated in sick preterm infants weighing 1500-2500 g, especially when restriction of fluid is mandated.https://acta.tums.ac.ir/index.php/acta/article/view/2989intravenous fluid therapypreterm infant |
| spellingShingle | F. Nili M. Ghafuri HYPOGLYCEMIA IN SICK PRETERM INFANTS AND THE THERAPEUTIC EFFECT OF 12.5% DEXTROSE IN WATER COMPARED WITH 10% DEXTROSE IN WATER Acta Medica Iranica intravenous fluid therapy preterm infant |
| title | HYPOGLYCEMIA IN SICK PRETERM INFANTS AND THE THERAPEUTIC EFFECT OF 12.5% DEXTROSE IN WATER COMPARED WITH 10% DEXTROSE IN WATER |
| title_full | HYPOGLYCEMIA IN SICK PRETERM INFANTS AND THE THERAPEUTIC EFFECT OF 12.5% DEXTROSE IN WATER COMPARED WITH 10% DEXTROSE IN WATER |
| title_fullStr | HYPOGLYCEMIA IN SICK PRETERM INFANTS AND THE THERAPEUTIC EFFECT OF 12.5% DEXTROSE IN WATER COMPARED WITH 10% DEXTROSE IN WATER |
| title_full_unstemmed | HYPOGLYCEMIA IN SICK PRETERM INFANTS AND THE THERAPEUTIC EFFECT OF 12.5% DEXTROSE IN WATER COMPARED WITH 10% DEXTROSE IN WATER |
| title_short | HYPOGLYCEMIA IN SICK PRETERM INFANTS AND THE THERAPEUTIC EFFECT OF 12.5% DEXTROSE IN WATER COMPARED WITH 10% DEXTROSE IN WATER |
| title_sort | hypoglycemia in sick preterm infants and the therapeutic effect of 12 5 dextrose in water compared with 10 dextrose in water |
| topic | intravenous fluid therapy preterm infant |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/2989 |
| work_keys_str_mv | AT fnilimghafuri hypoglycemiainsickpreterminfantsandthetherapeuticeffectof125dextroseinwatercomparedwith10dextroseinwater |