Application status and optimization suggestions of tumor organoids and CAR-T cell co-culture models

Application status and optimization suggestions of tumor organoids and CAR-T cell co-culture models

Abstract Tumor organoids, especially patient-derived organoids (PDOs) exhibit marked similarities in histopathological morphology, genomic alterations, and specific marker expression profiles to those of primary tumour tissues. They are applied in various fields including drug screening, gene editin...

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Bibliographic Details
Main Authors: Rong-Xuan Ning, Cun-Yu Liu, Shi-Qi Wang, Wen-Kai Li, Xia Kong, Zhi-Wei He
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Cancer Cell International
Subjects:
Tumor organoid
CAR-T therapy
Co-culture models
Online Access:https://doi.org/10.1186/s12935-024-03272-x

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