Spectrophotometric Determination of Methimazole by Silicomolybdenum Blue
Under optimum reaction conditions, Ammonium silicomolybdate could be quantitatively reduced to silicomolybdenum blue by hydrosulfuryl(-SH) in methimazole molecule, and the content of methimazole was determinated indirectly through determinating the absorbance of the silicomolybdenum blue. A novel me...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2018-01-01
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| Series: | E3S Web of Conferences |
| Online Access: | https://doi.org/10.1051/e3sconf/20185301046 |
| _version_ | 1818556751444705280 |
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| author | Wen Xinrong Tu Changqing |
| author_facet | Wen Xinrong Tu Changqing |
| author_sort | Wen Xinrong |
| collection | DOAJ |
| description | Under optimum reaction conditions, Ammonium silicomolybdate could be quantitatively reduced to silicomolybdenum blue by hydrosulfuryl(-SH) in methimazole molecule, and the content of methimazole was determinated indirectly through determinating the absorbance of the silicomolybdenum blue. A novel method for the spectrophotometric determination of methimazole by silicomolybdenum blue has been established. The results showed that the maximum absorption wavelength of silicomolybdenum blue is 730 nm, good linear relationship is obtained between the absorbance of silicomolybdenum blue and the concentration of methimazole in the range of 8.000-160.0μg/mL, and the equation of the linear regression is A=0.0757+11.547ρ (mg/mL) with a linear correlation coefficient is 0.9998. This proposed method has been applied to determinate of methimazole in tablets, and the results agree well with those obtained by pharmacopoeial method. |
| first_indexed | 2024-12-13T23:51:15Z |
| format | Article |
| id | doaj.art-08eec7acde2640b09dc5d22cb2fc0a12 |
| institution | Directory Open Access Journal |
| issn | 2267-1242 |
| language | English |
| last_indexed | 2024-12-13T23:51:15Z |
| publishDate | 2018-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | E3S Web of Conferences |
| spelling | doaj.art-08eec7acde2640b09dc5d22cb2fc0a122022-12-21T23:26:45ZengEDP SciencesE3S Web of Conferences2267-12422018-01-01530104610.1051/e3sconf/20185301046e3sconf_icaeer2018_01046Spectrophotometric Determination of Methimazole by Silicomolybdenum BlueWen XinrongTu ChangqingUnder optimum reaction conditions, Ammonium silicomolybdate could be quantitatively reduced to silicomolybdenum blue by hydrosulfuryl(-SH) in methimazole molecule, and the content of methimazole was determinated indirectly through determinating the absorbance of the silicomolybdenum blue. A novel method for the spectrophotometric determination of methimazole by silicomolybdenum blue has been established. The results showed that the maximum absorption wavelength of silicomolybdenum blue is 730 nm, good linear relationship is obtained between the absorbance of silicomolybdenum blue and the concentration of methimazole in the range of 8.000-160.0μg/mL, and the equation of the linear regression is A=0.0757+11.547ρ (mg/mL) with a linear correlation coefficient is 0.9998. This proposed method has been applied to determinate of methimazole in tablets, and the results agree well with those obtained by pharmacopoeial method.https://doi.org/10.1051/e3sconf/20185301046 |
| spellingShingle | Wen Xinrong Tu Changqing Spectrophotometric Determination of Methimazole by Silicomolybdenum Blue E3S Web of Conferences |
| title | Spectrophotometric Determination of Methimazole by Silicomolybdenum Blue |
| title_full | Spectrophotometric Determination of Methimazole by Silicomolybdenum Blue |
| title_fullStr | Spectrophotometric Determination of Methimazole by Silicomolybdenum Blue |
| title_full_unstemmed | Spectrophotometric Determination of Methimazole by Silicomolybdenum Blue |
| title_short | Spectrophotometric Determination of Methimazole by Silicomolybdenum Blue |
| title_sort | spectrophotometric determination of methimazole by silicomolybdenum blue |
| url | https://doi.org/10.1051/e3sconf/20185301046 |
| work_keys_str_mv | AT wenxinrong spectrophotometricdeterminationofmethimazolebysilicomolybdenumblue AT tuchangqing spectrophotometricdeterminationofmethimazolebysilicomolybdenumblue |