Genome editing of CCR5 by AsCpf1 renders CD4+T cells resistance to HIV-1 infection

Genome editing of CCR5 by AsCpf1 renders CD4+T cells resistance to HIV-1 infection

Abstract Background The chemokine receptor CCR5 is one of the co-receptor of HIV-1 infection. People with homozygous CCR5Δ32 deletion resist HIV-1 infection, which makes the CCR5 an important target for HIV-1 gene therapy. Although the CRISPR/Cas9 has ever been used for HIV-1 study, the newly develo...

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Bibliographic Details
Main Authors: Zhepeng Liu, Jin Liang, Shuliang Chen, Kewu Wang, Xianhao Liu, Beibei Liu, Yang Xia, Mingxiong Guo, Xiaoshi Zhang, Guihong Sun, Geng Tian
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Cell & Bioscience
Subjects:
CCR5
HIV-1
CRISPR/AsCpf1
HIV-1 resistance
Selective advantage
Online Access:http://link.springer.com/article/10.1186/s13578-020-00444-w

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