Efficacy and safety of small-incision corneal intrastromal lenticule implantation for hyperopia correction: a systematic review and meta-analysis
PurposeTo assess the efficacy and safety of intrastromal lenticule implantation for the treatment of hyperopia.MethodsA systematic search of PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Internet, and Wan Fang Database identified studies on small-incision intrastromal le...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-02-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1320235/full |
| _version_ | 1797305273360056320 |
|---|---|
| author | Yue Wang Jingjing Zheng Zuofeng Guo Xuejun Fang Xuejun Fang |
| author_facet | Yue Wang Jingjing Zheng Zuofeng Guo Xuejun Fang Xuejun Fang |
| author_sort | Yue Wang |
| collection | DOAJ |
| description | PurposeTo assess the efficacy and safety of intrastromal lenticule implantation for the treatment of hyperopia.MethodsA systematic search of PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Internet, and Wan Fang Database identified studies on small-incision intrastromal lenticule implantation for hyperopia correction until January 2023. The Joanna Briggs Institute (JBI) critical appraisal tool was used to assess the quality of the retrospective research, and the Methodological Index for Non-randomized Studies (MINORS) was used to assess the quality of the prospective research. This study included postoperative visual outcomes, corneal morphology, and biomechanical outcomes.ResultsA total of 456 articles were identified, of which 10 were included in the meta-analysis. Ten single-arm studies involving 190 eyes were included. A meta-analysis demonstrated that corneal intrastromal lenticule implantation treatment significantly improved hyperopia. Uncorrected distance visual acuity (UDVA) significantly improved compared to the preoperative value (p = 0.027), corrected distance visual acuity showed no difference compared to the preoperative value (p = 0.27), and 87% eyes have no loss of one or more lines in the Snellen lines of CDVA (p < 0.00001). There was a significant difference between the spherical equivalent refractive (SE) and preoperative examination (p < 0.00001), 52% of eyes had ±0.5 diopters (D) postoperative SE (p < 0.00001), and 74% eyes had ±1.0 D postoperative SE (p < 0.00001). The central corneal thickness (CCT) increased by 72.68 μm compared to that preoperatively (p < 0.00001), and corneal curvature increased by 4.18D (p < 0.00001). The Q-value decreased by 0.82 (p < 0.00001), and higher-order aberration (HOA) decreased by 0.66 (p < 0.00001).ConclusionSmall-incision intrastromal lenticule implantation may be an effective solution for correcting hyperopia. The effect of improved vision is significant, but further exploration is needed for changes in corneal biomechanics and long-term safety.Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42023432343. |
| first_indexed | 2024-03-08T00:23:31Z |
| format | Article |
| id | doaj.art-08f08f90ac4040b3a8d68fa2aec6e48a |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-08T00:23:31Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-08f08f90ac4040b3a8d68fa2aec6e48a2024-02-16T04:20:44ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-02-011110.3389/fmed.2024.13202351320235Efficacy and safety of small-incision corneal intrastromal lenticule implantation for hyperopia correction: a systematic review and meta-analysisYue Wang0Jingjing Zheng1Zuofeng Guo2Xuejun Fang3Xuejun Fang4Ophthalmology, Liaoning Aier Eye Hospital, Shenyang, ChinaOphthalmology, Liaoning Aier Eye Hospital, Shenyang, ChinaOphthalmology, Liaoning Aier Eye Hospital, Shenyang, ChinaOphthalmology, Liaoning Aier Eye Hospital, Shenyang, ChinaAIER School of Ophthalmology, Central South University, Changsha, ChinaPurposeTo assess the efficacy and safety of intrastromal lenticule implantation for the treatment of hyperopia.MethodsA systematic search of PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Internet, and Wan Fang Database identified studies on small-incision intrastromal lenticule implantation for hyperopia correction until January 2023. The Joanna Briggs Institute (JBI) critical appraisal tool was used to assess the quality of the retrospective research, and the Methodological Index for Non-randomized Studies (MINORS) was used to assess the quality of the prospective research. This study included postoperative visual outcomes, corneal morphology, and biomechanical outcomes.ResultsA total of 456 articles were identified, of which 10 were included in the meta-analysis. Ten single-arm studies involving 190 eyes were included. A meta-analysis demonstrated that corneal intrastromal lenticule implantation treatment significantly improved hyperopia. Uncorrected distance visual acuity (UDVA) significantly improved compared to the preoperative value (p = 0.027), corrected distance visual acuity showed no difference compared to the preoperative value (p = 0.27), and 87% eyes have no loss of one or more lines in the Snellen lines of CDVA (p < 0.00001). There was a significant difference between the spherical equivalent refractive (SE) and preoperative examination (p < 0.00001), 52% of eyes had ±0.5 diopters (D) postoperative SE (p < 0.00001), and 74% eyes had ±1.0 D postoperative SE (p < 0.00001). The central corneal thickness (CCT) increased by 72.68 μm compared to that preoperatively (p < 0.00001), and corneal curvature increased by 4.18D (p < 0.00001). The Q-value decreased by 0.82 (p < 0.00001), and higher-order aberration (HOA) decreased by 0.66 (p < 0.00001).ConclusionSmall-incision intrastromal lenticule implantation may be an effective solution for correcting hyperopia. The effect of improved vision is significant, but further exploration is needed for changes in corneal biomechanics and long-term safety.Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42023432343.https://www.frontiersin.org/articles/10.3389/fmed.2024.1320235/fulllenticule implantationhyperopiasmall incision lenticule extractionrefractivemeta-analysis |
| spellingShingle | Yue Wang Jingjing Zheng Zuofeng Guo Xuejun Fang Xuejun Fang Efficacy and safety of small-incision corneal intrastromal lenticule implantation for hyperopia correction: a systematic review and meta-analysis Frontiers in Medicine lenticule implantation hyperopia small incision lenticule extraction refractive meta-analysis |
| title | Efficacy and safety of small-incision corneal intrastromal lenticule implantation for hyperopia correction: a systematic review and meta-analysis |
| title_full | Efficacy and safety of small-incision corneal intrastromal lenticule implantation for hyperopia correction: a systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of small-incision corneal intrastromal lenticule implantation for hyperopia correction: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of small-incision corneal intrastromal lenticule implantation for hyperopia correction: a systematic review and meta-analysis |
| title_short | Efficacy and safety of small-incision corneal intrastromal lenticule implantation for hyperopia correction: a systematic review and meta-analysis |
| title_sort | efficacy and safety of small incision corneal intrastromal lenticule implantation for hyperopia correction a systematic review and meta analysis |
| topic | lenticule implantation hyperopia small incision lenticule extraction refractive meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1320235/full |
| work_keys_str_mv | AT yuewang efficacyandsafetyofsmallincisioncornealintrastromallenticuleimplantationforhyperopiacorrectionasystematicreviewandmetaanalysis AT jingjingzheng efficacyandsafetyofsmallincisioncornealintrastromallenticuleimplantationforhyperopiacorrectionasystematicreviewandmetaanalysis AT zuofengguo efficacyandsafetyofsmallincisioncornealintrastromallenticuleimplantationforhyperopiacorrectionasystematicreviewandmetaanalysis AT xuejunfang efficacyandsafetyofsmallincisioncornealintrastromallenticuleimplantationforhyperopiacorrectionasystematicreviewandmetaanalysis AT xuejunfang efficacyandsafetyofsmallincisioncornealintrastromallenticuleimplantationforhyperopiacorrectionasystematicreviewandmetaanalysis |