Dynamic fluctuations provide the basis of a conformational switch mechanism in apo cyclic AMP receptor protein.

Dynamic fluctuations provide the basis of a conformational switch mechanism in apo cyclic AMP receptor protein.

Escherichia coli cyclic AMP Receptor Protein (CRP) undergoes conformational changes with cAMP binding and allosterically promotes CRP to bind specifically to the DNA. In that, the structural and dynamic properties of apo CRP prior to cAMP binding are of interest for the comprehension of the activati...

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Bibliographic Details
Main Authors: Burcu Aykaç Fas, Yusuf Tutar, Türkan Haliloğlu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3715548?pdf=render

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