Extended Infusion of Meropenem in Neonatal Sepsis: A Historical Cohort Study
This single-center historical cohort study investigated the effectiveness and safety of extended infusion (EI) compared with short-term infusion (STI) of meropenem in neonatal sepsis. Patient electronic health records from Peking University Third Hospital (1 December 2011–1 April 2021) were screened...
| Main Authors: | , , , , , |
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/3/341 |
| _version_ | 1797473178583302144 |
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| author | Guangna Cao Pengxiang Zhou Hua Zhang Bangkai Sun Xiaomei Tong Yan Xing |
| author_facet | Guangna Cao Pengxiang Zhou Hua Zhang Bangkai Sun Xiaomei Tong Yan Xing |
| author_sort | Guangna Cao |
| collection | DOAJ |
| description | This single-center historical cohort study investigated the effectiveness and safety of extended infusion (EI) compared with short-term infusion (STI) of meropenem in neonatal sepsis. Patient electronic health records from Peking University Third Hospital (1 December 2011–1 April 2021) were screened. Neonates diagnosed with sepsis and treated with meropenem in the neonatal intensive care unit were included (256 patients) as STI (0.5 h, 129 patients) and EI (2–3 h, 127 patients) groups. Three-day clinical effectiveness and three-day microbial clearance were considered the main outcomes. Univariate and multivariate analyses were performed. Baseline characteristics were similar in both groups. EI of meropenem was associated with a significantly higher 3-day clinical effectiveness rate (0.335 (0.180, 0.623), <i>p</i> = 0.001) and 3-day microbial clearance (4.127 (1.235, 13.784), <i>p</i> = 0.021) than STI, with comparable safety. Subgroup analyses showed that neonates with very low birth weight benefited from EI in terms of 3-day clinical effectiveness rate (75.6% versus 56.6%, <i>p</i> = 0.007), with no significant difference in the 3-day clinical effectiveness (85.1% versus 78.3%, <i>p</i> = 0.325) and microbial clearance (6% versus 5%, <i>p</i> > 0.999) rates between 3 h and 2 h infusions. Thus, EI of meropenem may be associated with better effectiveness and comparable safety in treating neonatal sepsis than STI. Nonetheless, historically analyzed safety evaluation might be biased, and these findings need confirmation in randomized controlled trials of larger sample sizes. |
| first_indexed | 2024-03-09T20:12:15Z |
| format | Article |
| id | doaj.art-08f49af30f7f4b75a875d19444e3b049 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T20:12:15Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-08f49af30f7f4b75a875d19444e3b0492023-11-24T00:10:57ZengMDPI AGAntibiotics2079-63822022-03-0111334110.3390/antibiotics11030341Extended Infusion of Meropenem in Neonatal Sepsis: A Historical Cohort StudyGuangna Cao0Pengxiang Zhou1Hua Zhang2Bangkai Sun3Xiaomei Tong4Yan Xing5Department of Pediatrics, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Pharmacy, Peking University Third Hospital, Beijing 100191, ChinaResearch Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, ChinaInformation Management and Big Data Center, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Pediatrics, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Pediatrics, Peking University Third Hospital, Beijing 100191, ChinaThis single-center historical cohort study investigated the effectiveness and safety of extended infusion (EI) compared with short-term infusion (STI) of meropenem in neonatal sepsis. Patient electronic health records from Peking University Third Hospital (1 December 2011–1 April 2021) were screened. Neonates diagnosed with sepsis and treated with meropenem in the neonatal intensive care unit were included (256 patients) as STI (0.5 h, 129 patients) and EI (2–3 h, 127 patients) groups. Three-day clinical effectiveness and three-day microbial clearance were considered the main outcomes. Univariate and multivariate analyses were performed. Baseline characteristics were similar in both groups. EI of meropenem was associated with a significantly higher 3-day clinical effectiveness rate (0.335 (0.180, 0.623), <i>p</i> = 0.001) and 3-day microbial clearance (4.127 (1.235, 13.784), <i>p</i> = 0.021) than STI, with comparable safety. Subgroup analyses showed that neonates with very low birth weight benefited from EI in terms of 3-day clinical effectiveness rate (75.6% versus 56.6%, <i>p</i> = 0.007), with no significant difference in the 3-day clinical effectiveness (85.1% versus 78.3%, <i>p</i> = 0.325) and microbial clearance (6% versus 5%, <i>p</i> > 0.999) rates between 3 h and 2 h infusions. Thus, EI of meropenem may be associated with better effectiveness and comparable safety in treating neonatal sepsis than STI. Nonetheless, historically analyzed safety evaluation might be biased, and these findings need confirmation in randomized controlled trials of larger sample sizes.https://www.mdpi.com/2079-6382/11/3/341meropenemextended infusionshort-term infusionneonatal sepsishistorical cohort study |
| spellingShingle | Guangna Cao Pengxiang Zhou Hua Zhang Bangkai Sun Xiaomei Tong Yan Xing Extended Infusion of Meropenem in Neonatal Sepsis: A Historical Cohort Study Antibiotics meropenem extended infusion short-term infusion neonatal sepsis historical cohort study |
| title | Extended Infusion of Meropenem in Neonatal Sepsis: A Historical Cohort Study |
| title_full | Extended Infusion of Meropenem in Neonatal Sepsis: A Historical Cohort Study |
| title_fullStr | Extended Infusion of Meropenem in Neonatal Sepsis: A Historical Cohort Study |
| title_full_unstemmed | Extended Infusion of Meropenem in Neonatal Sepsis: A Historical Cohort Study |
| title_short | Extended Infusion of Meropenem in Neonatal Sepsis: A Historical Cohort Study |
| title_sort | extended infusion of meropenem in neonatal sepsis a historical cohort study |
| topic | meropenem extended infusion short-term infusion neonatal sepsis historical cohort study |
| url | https://www.mdpi.com/2079-6382/11/3/341 |
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