Case report: Uncommon multiple metastases from occult breast cancer revealed by 68Ga-DOTATATE PET/CT
Occult breast cancer is an uncommon type of breast cancer and its diagnosis is challenging. It is usually invisible on multiple imaging examines. Metastases to the rectum and inguinal lymph nodes from occult breast lobular cancer are even rarer. 68Ga-DOTA peptides can image neuroendocrine tumors by...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1106890/full |
| _version_ | 1797900400901226496 |
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| author | Tianyuan Hu Rongqin Zhang Rongqin Zhang Bing Zhang Shanzhen He Lian Liu Yan Zou Junhao Huang Bing Wang Ping Hu Zhanwen Zhang |
| author_facet | Tianyuan Hu Rongqin Zhang Rongqin Zhang Bing Zhang Shanzhen He Lian Liu Yan Zou Junhao Huang Bing Wang Ping Hu Zhanwen Zhang |
| author_sort | Tianyuan Hu |
| collection | DOAJ |
| description | Occult breast cancer is an uncommon type of breast cancer and its diagnosis is challenging. It is usually invisible on multiple imaging examines. Metastases to the rectum and inguinal lymph nodes from occult breast lobular cancer are even rarer. 68Ga-DOTA peptides can image neuroendocrine tumors by targeting specific somatostatin receptors. Besides, other tumors, including breast cancer, have been shown to express somatostatin receptors. In this case, we presented a 63-year-old woman who underwent both 18F-FDG and 68Ga-DOTATATE PET/CT due to a rectal polyp. An endoscopic excision biopsy confirmed metastatic carcinoma of suspected breast origin, but subsequent ultrasound and MRI showed no signs of malignancy in the breast and adnexa uteri. PET/CT showed obvious 68Ga-DOTATATE activity in bilateral axillary and right inguinal lymph nodes with mild 18F-FDG uptake. Final histopathology at the left axillary, right inguinal lymph nodes, and rectum indicated metastases from breast cancer while the origin remained radiologically occult. Additionally, one uterine fibroids was found with positive uptake of 68Ga-DOTATATE and negative uptake of 18F-FDG. This case suggested that 68Ga-DOTATAE PET/CT may be an effective supplement in diagnosing OBC lymph node metastases with mild 18F-FDG uptake, and it may provide a new technology for the clinical diagnosis of occult breast cancer. |
| first_indexed | 2024-04-10T08:45:25Z |
| format | Article |
| id | doaj.art-08f7d52c5a2249b9b29ca9a959875dc5 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T08:45:25Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-08f7d52c5a2249b9b29ca9a959875dc52023-02-22T08:50:33ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-02-011310.3389/fonc.2023.11068901106890Case report: Uncommon multiple metastases from occult breast cancer revealed by 68Ga-DOTATATE PET/CTTianyuan Hu0Rongqin Zhang1Rongqin Zhang2Bing Zhang3Shanzhen He4Lian Liu5Yan Zou6Junhao Huang7Bing Wang8Ping Hu9Zhanwen Zhang10Department of Nuclear Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Nuclear Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Nuclear Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, ChinaDepartment of Nuclear Medicine and Medical Imaging, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Nuclear Medicine, Guangdong Provincial People’s Hospital, Guangzhou, Guangdong, ChinaDepartment of Nuclear Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Nuclear Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Nuclear Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Nuclear Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Nuclear Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Nuclear Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaOccult breast cancer is an uncommon type of breast cancer and its diagnosis is challenging. It is usually invisible on multiple imaging examines. Metastases to the rectum and inguinal lymph nodes from occult breast lobular cancer are even rarer. 68Ga-DOTA peptides can image neuroendocrine tumors by targeting specific somatostatin receptors. Besides, other tumors, including breast cancer, have been shown to express somatostatin receptors. In this case, we presented a 63-year-old woman who underwent both 18F-FDG and 68Ga-DOTATATE PET/CT due to a rectal polyp. An endoscopic excision biopsy confirmed metastatic carcinoma of suspected breast origin, but subsequent ultrasound and MRI showed no signs of malignancy in the breast and adnexa uteri. PET/CT showed obvious 68Ga-DOTATATE activity in bilateral axillary and right inguinal lymph nodes with mild 18F-FDG uptake. Final histopathology at the left axillary, right inguinal lymph nodes, and rectum indicated metastases from breast cancer while the origin remained radiologically occult. Additionally, one uterine fibroids was found with positive uptake of 68Ga-DOTATATE and negative uptake of 18F-FDG. This case suggested that 68Ga-DOTATAE PET/CT may be an effective supplement in diagnosing OBC lymph node metastases with mild 18F-FDG uptake, and it may provide a new technology for the clinical diagnosis of occult breast cancer.https://www.frontiersin.org/articles/10.3389/fonc.2023.1106890/full68Ga-DOTATATE18F-FDGPET/CToccult breast cancerlymph node metastases |
| spellingShingle | Tianyuan Hu Rongqin Zhang Rongqin Zhang Bing Zhang Shanzhen He Lian Liu Yan Zou Junhao Huang Bing Wang Ping Hu Zhanwen Zhang Case report: Uncommon multiple metastases from occult breast cancer revealed by 68Ga-DOTATATE PET/CT Frontiers in Oncology 68Ga-DOTATATE 18F-FDG PET/CT occult breast cancer lymph node metastases |
| title | Case report: Uncommon multiple metastases from occult breast cancer revealed by 68Ga-DOTATATE PET/CT |
| title_full | Case report: Uncommon multiple metastases from occult breast cancer revealed by 68Ga-DOTATATE PET/CT |
| title_fullStr | Case report: Uncommon multiple metastases from occult breast cancer revealed by 68Ga-DOTATATE PET/CT |
| title_full_unstemmed | Case report: Uncommon multiple metastases from occult breast cancer revealed by 68Ga-DOTATATE PET/CT |
| title_short | Case report: Uncommon multiple metastases from occult breast cancer revealed by 68Ga-DOTATATE PET/CT |
| title_sort | case report uncommon multiple metastases from occult breast cancer revealed by 68ga dotatate pet ct |
| topic | 68Ga-DOTATATE 18F-FDG PET/CT occult breast cancer lymph node metastases |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1106890/full |
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