Impaired JAK-STAT pathway signaling in leukocytes of the frail elderly

Impaired JAK-STAT pathway signaling in leukocytes of the frail elderly

Abstract Background Elderly often show reduced immune functioning and can develop chronic low-grade inflammation. Why some elderly are more prone to become frail is unknown. We investigated whether frailty is associated with altered cytokine signaling through the JAK-STAT pathway in leukocytes of 34...

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Main Authors: Leonard Daniël Samson, Peter Engelfriet, W. M. Monique Verschuren, H. Susan J. Picavet, José A. Ferreira, Mary-lène de Zeeuw-Brouwer, Anne-Marie Buisman, A. Mieke H. Boots
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Immunity & Ageing
Subjects:
Immunosenescence
Frailty
JAK-STAT pathway
Immune function
Phospho-flow cytometry
Chronic low-grade inflammation
Online Access:https://doi.org/10.1186/s12979-021-00261-w

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