Features to validate cerebral toxoplasmosis
Introduction Neurotoxoplasmosis (NT) sometimes manifests unusual characteristics. Methods We analyzed 85 patients with NT and AIDS according to clinical, cerebrospinal fluid, cranial magnetic resonance, and polymerase chain reaction (PCR) characteristics. Results In 8.5%, focal neurological defi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Medicina Tropical (SBMT)
2013-06-01
|
| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000300373&lng=en&tlng=en |
| _version_ | 1817977155224600576 |
|---|---|
| author | Carolina da Cunha Correia Heloisa Ramos Lacerda Melo Vlaudia Maria Assis Costa Alessandra Mertens Brainer |
| author_facet | Carolina da Cunha Correia Heloisa Ramos Lacerda Melo Vlaudia Maria Assis Costa Alessandra Mertens Brainer |
| author_sort | Carolina da Cunha Correia |
| collection | DOAJ |
| description | Introduction Neurotoxoplasmosis (NT) sometimes manifests unusual characteristics. Methods We analyzed 85 patients with NT and AIDS according to clinical, cerebrospinal fluid, cranial magnetic resonance, and polymerase chain reaction (PCR) characteristics. Results In 8.5%, focal neurological deficits were absent and 16.4% had single cerebral lesions. Increased sensitivity of PCR for Toxoplasma gondii DNA in the central nervous system was associated with pleocytosis and presence of >4 encephalic lesions. Conclusions Patients with NT may present without focal neurological deficit and NT may occur with presence of a single cerebral lesion. Greater numbers of lesions and greater cellularity in cerebrospinal fluid improve the sensitivity of PCR to T gondii. |
| first_indexed | 2024-04-13T22:13:20Z |
| format | Article |
| id | doaj.art-08fbc835d9134c5a9d64a415421a0ada |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T22:13:20Z |
| publishDate | 2013-06-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-08fbc835d9134c5a9d64a415421a0ada2022-12-22T02:27:39ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492013-06-0146337337610.1590/0037-8682-1202-2013S0037-86822013000300373Features to validate cerebral toxoplasmosisCarolina da Cunha CorreiaHeloisa Ramos Lacerda MeloVlaudia Maria Assis CostaAlessandra Mertens BrainerIntroduction Neurotoxoplasmosis (NT) sometimes manifests unusual characteristics. Methods We analyzed 85 patients with NT and AIDS according to clinical, cerebrospinal fluid, cranial magnetic resonance, and polymerase chain reaction (PCR) characteristics. Results In 8.5%, focal neurological deficits were absent and 16.4% had single cerebral lesions. Increased sensitivity of PCR for Toxoplasma gondii DNA in the central nervous system was associated with pleocytosis and presence of >4 encephalic lesions. Conclusions Patients with NT may present without focal neurological deficit and NT may occur with presence of a single cerebral lesion. Greater numbers of lesions and greater cellularity in cerebrospinal fluid improve the sensitivity of PCR to T gondii.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000300373&lng=en&tlng=enAIDSCerebral toxoplasmosisDiagnosis |
| spellingShingle | Carolina da Cunha Correia Heloisa Ramos Lacerda Melo Vlaudia Maria Assis Costa Alessandra Mertens Brainer Features to validate cerebral toxoplasmosis Revista da Sociedade Brasileira de Medicina Tropical AIDS Cerebral toxoplasmosis Diagnosis |
| title | Features to validate cerebral toxoplasmosis |
| title_full | Features to validate cerebral toxoplasmosis |
| title_fullStr | Features to validate cerebral toxoplasmosis |
| title_full_unstemmed | Features to validate cerebral toxoplasmosis |
| title_short | Features to validate cerebral toxoplasmosis |
| title_sort | features to validate cerebral toxoplasmosis |
| topic | AIDS Cerebral toxoplasmosis Diagnosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000300373&lng=en&tlng=en |
| work_keys_str_mv | AT carolinadacunhacorreia featurestovalidatecerebraltoxoplasmosis AT heloisaramoslacerdamelo featurestovalidatecerebraltoxoplasmosis AT vlaudiamariaassiscosta featurestovalidatecerebraltoxoplasmosis AT alessandramertensbrainer featurestovalidatecerebraltoxoplasmosis |