Diagnostic value of urine sCD163 levels for sepsis and relevant acute kidney injury: a prospective study
<p>Abstract</p> <p>Background</p> <p>Sepsis is a common syndrome in critically ill patients and easily leads to the occurrence of acute kidney injury (AKI), with high mortality rates. This study aimed to investigate the diagnostic value of urine soluble CD163 (sCD163) f...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-09-01
|
| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2369/13/123 |
| _version_ | 1818916246226206720 |
|---|---|
| author | Su Longxiang Feng Lin Liu Changting Jiang Zhaoxu Li Ming Xiao Kun Yan Peng Jia Yanhong Feng Dan Xie Lixin |
| author_facet | Su Longxiang Feng Lin Liu Changting Jiang Zhaoxu Li Ming Xiao Kun Yan Peng Jia Yanhong Feng Dan Xie Lixin |
| author_sort | Su Longxiang |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Sepsis is a common syndrome in critically ill patients and easily leads to the occurrence of acute kidney injury (AKI), with high mortality rates. This study aimed to investigate the diagnostic value of urine soluble CD163 (sCD163) for identification of sepsis, severity of sepsis, and for secondary AKI, and to assess the patients’ prognosis.</p> <p>Methods</p> <p>We enrolled 20 cases with systemic inflammatory response syndrome (SIRS), 40 cases with sepsis (further divided into 17 sepsis cases and 23 severe sepsis cases) admitted to the intensive care unit (ICU), and 20 control cases. Results for urine sCD163 were recorded on the day of admission to the ICU, and AKI occurrence was noted.</p> <p>Results</p> <p>On the day of ICU admission, the sepsis group exhibited higher levels of urine sCD163 (74.8 ng/ml; range: 47.9-148.3 ng/ml) compared with those in the SIRS group (31.9 ng/ml; 16.8-48.0, <it>P < 0.001</it>). The area under the curve (AUC) was 0.83 (95% confidence interval [CI]: 0.72-0.94, <it>P < 0.001</it>) the sensitivity was 0.83, and the specificity was 0.75 (based on a cut-off point of 43.0 ng/ml). Moreover, the severe sepsis group appeared to have a higher level of sCD163 compared with that in the sepsis group (76.2; 47.2-167.5 ng/ml vs. 74.2; 46.2-131.6 ng/ml), but this was not significant. For 15 patients with AKI, urine sCD163 levels at AKI diagnosis were significantly higher than those of the remaining 35 sepsis patients upon ICU admission (121.0; 74.6-299.1 ng/ml vs. 61.8; 42.8-128.3 ng/ml, <it>P = 0.049</it>). The AUC for urine sCD163 was 0.688 (95% CI: 0.51-0.87, <it>P = 0.049</it>). Sepsis patients with a poor prognosis showed a higher urine sCD163 level at ICU admission (98.6; 50.3-275.6 ng/ml vs. 68.0; 44.8-114.5 ng/ml), but this was not significant. Patients with AKI with a poor prognosis had higher sCD163 levels than those in patients with a better prognosis (205.9; 38.6-766.0 ng/ml vs. 80.9; 74.9-141.0 ng/ml), but this was not significant.</p> <p>Conclusions</p> <p>This study shows, for the first time, the potential value of urine sCD163 levels for identifying sepsis and diagnosing AKI, as well as for assessment of patients’ prognosis.</p> <p>Trial Registration</p> <p>ChiCTR-ONC-10000812</p> |
| first_indexed | 2024-12-20T00:15:07Z |
| format | Article |
| id | doaj.art-08fc3143e8e04823b825e80d62702958 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-20T00:15:07Z |
| publishDate | 2012-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-08fc3143e8e04823b825e80d627029582022-12-21T20:00:22ZengBMCBMC Nephrology1471-23692012-09-0113112310.1186/1471-2369-13-123Diagnostic value of urine sCD163 levels for sepsis and relevant acute kidney injury: a prospective studySu LongxiangFeng LinLiu ChangtingJiang ZhaoxuLi MingXiao KunYan PengJia YanhongFeng DanXie Lixin<p>Abstract</p> <p>Background</p> <p>Sepsis is a common syndrome in critically ill patients and easily leads to the occurrence of acute kidney injury (AKI), with high mortality rates. This study aimed to investigate the diagnostic value of urine soluble CD163 (sCD163) for identification of sepsis, severity of sepsis, and for secondary AKI, and to assess the patients’ prognosis.</p> <p>Methods</p> <p>We enrolled 20 cases with systemic inflammatory response syndrome (SIRS), 40 cases with sepsis (further divided into 17 sepsis cases and 23 severe sepsis cases) admitted to the intensive care unit (ICU), and 20 control cases. Results for urine sCD163 were recorded on the day of admission to the ICU, and AKI occurrence was noted.</p> <p>Results</p> <p>On the day of ICU admission, the sepsis group exhibited higher levels of urine sCD163 (74.8 ng/ml; range: 47.9-148.3 ng/ml) compared with those in the SIRS group (31.9 ng/ml; 16.8-48.0, <it>P < 0.001</it>). The area under the curve (AUC) was 0.83 (95% confidence interval [CI]: 0.72-0.94, <it>P < 0.001</it>) the sensitivity was 0.83, and the specificity was 0.75 (based on a cut-off point of 43.0 ng/ml). Moreover, the severe sepsis group appeared to have a higher level of sCD163 compared with that in the sepsis group (76.2; 47.2-167.5 ng/ml vs. 74.2; 46.2-131.6 ng/ml), but this was not significant. For 15 patients with AKI, urine sCD163 levels at AKI diagnosis were significantly higher than those of the remaining 35 sepsis patients upon ICU admission (121.0; 74.6-299.1 ng/ml vs. 61.8; 42.8-128.3 ng/ml, <it>P = 0.049</it>). The AUC for urine sCD163 was 0.688 (95% CI: 0.51-0.87, <it>P = 0.049</it>). Sepsis patients with a poor prognosis showed a higher urine sCD163 level at ICU admission (98.6; 50.3-275.6 ng/ml vs. 68.0; 44.8-114.5 ng/ml), but this was not significant. Patients with AKI with a poor prognosis had higher sCD163 levels than those in patients with a better prognosis (205.9; 38.6-766.0 ng/ml vs. 80.9; 74.9-141.0 ng/ml), but this was not significant.</p> <p>Conclusions</p> <p>This study shows, for the first time, the potential value of urine sCD163 levels for identifying sepsis and diagnosing AKI, as well as for assessment of patients’ prognosis.</p> <p>Trial Registration</p> <p>ChiCTR-ONC-10000812</p>http://www.biomedcentral.com/1471-2369/13/123UrineSoluble CD163 (sCD163)SepsisSystemic inflammatory response syndrome (SIRS)PrognosisAcute kidney injury (AKI) |
| spellingShingle | Su Longxiang Feng Lin Liu Changting Jiang Zhaoxu Li Ming Xiao Kun Yan Peng Jia Yanhong Feng Dan Xie Lixin Diagnostic value of urine sCD163 levels for sepsis and relevant acute kidney injury: a prospective study BMC Nephrology Urine Soluble CD163 (sCD163) Sepsis Systemic inflammatory response syndrome (SIRS) Prognosis Acute kidney injury (AKI) |
| title | Diagnostic value of urine sCD163 levels for sepsis and relevant acute kidney injury: a prospective study |
| title_full | Diagnostic value of urine sCD163 levels for sepsis and relevant acute kidney injury: a prospective study |
| title_fullStr | Diagnostic value of urine sCD163 levels for sepsis and relevant acute kidney injury: a prospective study |
| title_full_unstemmed | Diagnostic value of urine sCD163 levels for sepsis and relevant acute kidney injury: a prospective study |
| title_short | Diagnostic value of urine sCD163 levels for sepsis and relevant acute kidney injury: a prospective study |
| title_sort | diagnostic value of urine scd163 levels for sepsis and relevant acute kidney injury a prospective study |
| topic | Urine Soluble CD163 (sCD163) Sepsis Systemic inflammatory response syndrome (SIRS) Prognosis Acute kidney injury (AKI) |
| url | http://www.biomedcentral.com/1471-2369/13/123 |
| work_keys_str_mv | AT sulongxiang diagnosticvalueofurinescd163levelsforsepsisandrelevantacutekidneyinjuryaprospectivestudy AT fenglin diagnosticvalueofurinescd163levelsforsepsisandrelevantacutekidneyinjuryaprospectivestudy AT liuchangting diagnosticvalueofurinescd163levelsforsepsisandrelevantacutekidneyinjuryaprospectivestudy AT jiangzhaoxu diagnosticvalueofurinescd163levelsforsepsisandrelevantacutekidneyinjuryaprospectivestudy AT liming diagnosticvalueofurinescd163levelsforsepsisandrelevantacutekidneyinjuryaprospectivestudy AT xiaokun diagnosticvalueofurinescd163levelsforsepsisandrelevantacutekidneyinjuryaprospectivestudy AT yanpeng diagnosticvalueofurinescd163levelsforsepsisandrelevantacutekidneyinjuryaprospectivestudy AT jiayanhong diagnosticvalueofurinescd163levelsforsepsisandrelevantacutekidneyinjuryaprospectivestudy AT fengdan diagnosticvalueofurinescd163levelsforsepsisandrelevantacutekidneyinjuryaprospectivestudy AT xielixin diagnosticvalueofurinescd163levelsforsepsisandrelevantacutekidneyinjuryaprospectivestudy |