Evaluation of the Prevalence of HER-2 Expression and Its Relationship with Prognostic Parameters in Colorectal Carcinoma
Introduction:Colorectal carcinoma (CRC) is one of the most important causes of cancer-related deaths, and its incidence has been increasing in recent years. Considering the high mortality rates, new therapeutic targets are needed to improve survival in advanced disease. HER-2 is a member of the Epid...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2020-05-01
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| Series: | İstanbul Medical Journal |
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http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/evaluation-of-the-prevalence-of-her-2-expression-a/38478
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| _version_ | 1797922859042996224 |
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| author | Cansu Benli Işık Saime Gül Barut |
| author_facet | Cansu Benli Işık Saime Gül Barut |
| author_sort | Cansu Benli Işık |
| collection | DOAJ |
| description | Introduction:Colorectal carcinoma (CRC) is one of the most important causes of cancer-related deaths, and its incidence has been increasing in recent years. Considering the high mortality rates, new therapeutic targets are needed to improve survival in advanced disease. HER-2 is a member of the Epidermal Growth Factor Receptor family. Overexpression of HER-2 is related to malignant transformation, apoptosis and increased proliferation. In this study, the frequency of HER-2 expression in CRC and its relationship with prognostic parameters were examined.Methods:A total of 123 colorectal resection cases diagnosed as CRC in 2015-2016 in the Pathology Department of Haseki Research and Training Hospital were included in the study. Clinicopathological prognostic parameters were evaluated. Immunohistochemical staining of HER-2 was performed on slides obtained from selected paraffin blocks. The results of staining were scored as 0, 1+, 2+ or 3+. For statistical analysis, HER-2 scores of 0 and 1+ were considered as negative, (2+) scores as equivocal and (3+) scores as positive.Results:3+, 2+ and 1+ immunoreactivity (strong, medium and weak intensity of membrane staining, respectively) was detected in 13%, 21% and 16% of cases, respectively. When we compared the results of HER-2 status with the clinicopathological parameters, we found a correlation between HER-2 and distant metastasis. The distant metastasis rate was higher in HER-2-positive patients than in equivocal and negative patients. There was no significant relationship between HER-2 expression and other clinicopathological parameters we evaluated.Conclusion:Considering these HER-2 expression levels which not scarce, therapies targeting the HER-2 receptor can be a promising part of treatment regimes, although they are not the main treatment option in CRC. |
| first_indexed | 2024-04-10T14:38:55Z |
| format | Article |
| id | doaj.art-08fe3784d6124a01bd66eaaebcc10a5b |
| institution | Directory Open Access Journal |
| issn | 2619-9793 2148-094X |
| language | English |
| last_indexed | 2024-04-10T14:38:55Z |
| publishDate | 2020-05-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj.art-08fe3784d6124a01bd66eaaebcc10a5b2023-02-15T16:08:19ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2020-05-0121320721210.4274/imj.galenos.2020.5656313049054Evaluation of the Prevalence of HER-2 Expression and Its Relationship with Prognostic Parameters in Colorectal CarcinomaCansu Benli Işık0Saime Gül Barut1 University of Health Sciences Turkey, Samsun Training and Research Hospital, Clinic of Medical Pathology, Samsun, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Medical Pathology, İstanbul, Turkey Introduction:Colorectal carcinoma (CRC) is one of the most important causes of cancer-related deaths, and its incidence has been increasing in recent years. Considering the high mortality rates, new therapeutic targets are needed to improve survival in advanced disease. HER-2 is a member of the Epidermal Growth Factor Receptor family. Overexpression of HER-2 is related to malignant transformation, apoptosis and increased proliferation. In this study, the frequency of HER-2 expression in CRC and its relationship with prognostic parameters were examined.Methods:A total of 123 colorectal resection cases diagnosed as CRC in 2015-2016 in the Pathology Department of Haseki Research and Training Hospital were included in the study. Clinicopathological prognostic parameters were evaluated. Immunohistochemical staining of HER-2 was performed on slides obtained from selected paraffin blocks. The results of staining were scored as 0, 1+, 2+ or 3+. For statistical analysis, HER-2 scores of 0 and 1+ were considered as negative, (2+) scores as equivocal and (3+) scores as positive.Results:3+, 2+ and 1+ immunoreactivity (strong, medium and weak intensity of membrane staining, respectively) was detected in 13%, 21% and 16% of cases, respectively. When we compared the results of HER-2 status with the clinicopathological parameters, we found a correlation between HER-2 and distant metastasis. The distant metastasis rate was higher in HER-2-positive patients than in equivocal and negative patients. There was no significant relationship between HER-2 expression and other clinicopathological parameters we evaluated.Conclusion:Considering these HER-2 expression levels which not scarce, therapies targeting the HER-2 receptor can be a promising part of treatment regimes, although they are not the main treatment option in CRC. http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/evaluation-of-the-prevalence-of-her-2-expression-a/38478 colorectal carcinomaher-2c-erbb-2prognostic parameters |
| spellingShingle | Cansu Benli Işık Saime Gül Barut Evaluation of the Prevalence of HER-2 Expression and Its Relationship with Prognostic Parameters in Colorectal Carcinoma İstanbul Medical Journal colorectal carcinoma her-2 c-erbb-2 prognostic parameters |
| title | Evaluation of the Prevalence of HER-2 Expression and Its Relationship with Prognostic Parameters in Colorectal Carcinoma |
| title_full | Evaluation of the Prevalence of HER-2 Expression and Its Relationship with Prognostic Parameters in Colorectal Carcinoma |
| title_fullStr | Evaluation of the Prevalence of HER-2 Expression and Its Relationship with Prognostic Parameters in Colorectal Carcinoma |
| title_full_unstemmed | Evaluation of the Prevalence of HER-2 Expression and Its Relationship with Prognostic Parameters in Colorectal Carcinoma |
| title_short | Evaluation of the Prevalence of HER-2 Expression and Its Relationship with Prognostic Parameters in Colorectal Carcinoma |
| title_sort | evaluation of the prevalence of her 2 expression and its relationship with prognostic parameters in colorectal carcinoma |
| topic | colorectal carcinoma her-2 c-erbb-2 prognostic parameters |
| url |
http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/evaluation-of-the-prevalence-of-her-2-expression-a/38478
|
| work_keys_str_mv | AT cansubenliisık evaluationoftheprevalenceofher2expressionanditsrelationshipwithprognosticparametersincolorectalcarcinoma AT saimegulbarut evaluationoftheprevalenceofher2expressionanditsrelationshipwithprognosticparametersincolorectalcarcinoma |