Applications of <i>Perilla frutescens</i> Extracts in Clinical Practice
(1) Background: <i>Perilla frutescens</i> (L.) Britt. is an important pharmaceutical crop that remains a focus point for researchers worldwide due to its complex phytochemical constituents, medicinal effects, and nutraceutical properties. The literature data are based on animal and cell...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/3/727 |
| _version_ | 1827751581630595072 |
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| author | Gigi Adam Silvia Robu Mihaela-Magdalena Flutur Oana Cioanca Ingrid-Andrada Vasilache Ana-Maria Adam Cornelia Mircea Aurel Nechita Valeriu Harabor AnaMaria Harabor Monica Hancianu |
| author_facet | Gigi Adam Silvia Robu Mihaela-Magdalena Flutur Oana Cioanca Ingrid-Andrada Vasilache Ana-Maria Adam Cornelia Mircea Aurel Nechita Valeriu Harabor AnaMaria Harabor Monica Hancianu |
| author_sort | Gigi Adam |
| collection | DOAJ |
| description | (1) Background: <i>Perilla frutescens</i> (L.) Britt. is an important pharmaceutical crop that remains a focus point for researchers worldwide due to its complex phytochemical constituents, medicinal effects, and nutraceutical properties. The literature data are based on animal and cell culture studies, so the clinical evidence for the therapeutic effects is poorly outlined. The aim of this review was to provide an updated and thorough understanding of <i>Perilla frutescens</i> applications in clinical practice using data derived from human studies, and to outline the potential directions and perspectives for further studies on this crop. (2) Methods: Medline, Embase, and Cochrane databases were used to find relevant studies. All interventional studies that evaluated the effect of <i>Perilla frutescens</i> in human subjects were assessed. (3) Results: The main perspectives that can be contoured from the presented literature evaluation are an important clinical effect of <i>Perilla frutescens</i> extracts on allergic rhinoconjuctivitis, especially in young populations, a potent hypolipemiant effect that, in conjunction with increased serum biological antioxidant potential, determines significant improvements in cognitive function and a wide variety of miscellaneous clinical effects that need further exploration. (4) Conclusions: Supplementary research is needed in order to demonstrate the therapeutic effects of <i>Perilla frutescens</i> in controlled clinical settings. |
| first_indexed | 2024-03-11T07:00:09Z |
| format | Article |
| id | doaj.art-0903458e217c485ab4087b97b44cf894 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T07:00:09Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-0903458e217c485ab4087b97b44cf8942023-11-17T09:18:55ZengMDPI AGAntioxidants2076-39212023-03-0112372710.3390/antiox12030727Applications of <i>Perilla frutescens</i> Extracts in Clinical PracticeGigi Adam0Silvia Robu1Mihaela-Magdalena Flutur2Oana Cioanca3Ingrid-Andrada Vasilache4Ana-Maria Adam5Cornelia Mircea6Aurel Nechita7Valeriu Harabor8AnaMaria Harabor9Monica Hancianu10Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaFaculty of Medicine and Pharmacy, “Dunarea de Jos” University, 35 Al. I. Cuza Street, 800216 Galati, RomaniaFaculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaFaculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Obstetrics and Gynecology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Medicine and Pharmacy, “Dunarea de Jos” University, 35 Al. I. Cuza Street, 800216 Galati, RomaniaFaculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaFaculty of Medicine and Pharmacy, “Dunarea de Jos” University, 35 Al. I. Cuza Street, 800216 Galati, RomaniaFaculty of Medicine and Pharmacy, “Dunarea de Jos” University, 35 Al. I. Cuza Street, 800216 Galati, RomaniaFaculty of Medicine and Pharmacy, “Dunarea de Jos” University, 35 Al. I. Cuza Street, 800216 Galati, RomaniaFaculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania(1) Background: <i>Perilla frutescens</i> (L.) Britt. is an important pharmaceutical crop that remains a focus point for researchers worldwide due to its complex phytochemical constituents, medicinal effects, and nutraceutical properties. The literature data are based on animal and cell culture studies, so the clinical evidence for the therapeutic effects is poorly outlined. The aim of this review was to provide an updated and thorough understanding of <i>Perilla frutescens</i> applications in clinical practice using data derived from human studies, and to outline the potential directions and perspectives for further studies on this crop. (2) Methods: Medline, Embase, and Cochrane databases were used to find relevant studies. All interventional studies that evaluated the effect of <i>Perilla frutescens</i> in human subjects were assessed. (3) Results: The main perspectives that can be contoured from the presented literature evaluation are an important clinical effect of <i>Perilla frutescens</i> extracts on allergic rhinoconjuctivitis, especially in young populations, a potent hypolipemiant effect that, in conjunction with increased serum biological antioxidant potential, determines significant improvements in cognitive function and a wide variety of miscellaneous clinical effects that need further exploration. (4) Conclusions: Supplementary research is needed in order to demonstrate the therapeutic effects of <i>Perilla frutescens</i> in controlled clinical settings.https://www.mdpi.com/2076-3921/12/3/727<i>Perilla frutescens</i>anti-inflammatory effectanti-allergic effectanti-oxidantshypolipemiant |
| spellingShingle | Gigi Adam Silvia Robu Mihaela-Magdalena Flutur Oana Cioanca Ingrid-Andrada Vasilache Ana-Maria Adam Cornelia Mircea Aurel Nechita Valeriu Harabor AnaMaria Harabor Monica Hancianu Applications of <i>Perilla frutescens</i> Extracts in Clinical Practice Antioxidants <i>Perilla frutescens</i> anti-inflammatory effect anti-allergic effect anti-oxidants hypolipemiant |
| title | Applications of <i>Perilla frutescens</i> Extracts in Clinical Practice |
| title_full | Applications of <i>Perilla frutescens</i> Extracts in Clinical Practice |
| title_fullStr | Applications of <i>Perilla frutescens</i> Extracts in Clinical Practice |
| title_full_unstemmed | Applications of <i>Perilla frutescens</i> Extracts in Clinical Practice |
| title_short | Applications of <i>Perilla frutescens</i> Extracts in Clinical Practice |
| title_sort | applications of i perilla frutescens i extracts in clinical practice |
| topic | <i>Perilla frutescens</i> anti-inflammatory effect anti-allergic effect anti-oxidants hypolipemiant |
| url | https://www.mdpi.com/2076-3921/12/3/727 |
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