Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites
Ganoderma lucidum is a versatile mushroom. Polysaccharides and triterpenoids are the major bioactive compounds and have been used as traditional medicinal mushrooms since ancient times. They are currently used as nutraceuticals and functional foods. G. lucidum extracts and their bioactive compounds...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024016384 |
| _version_ | 1797304386287828992 |
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| author | Md Faruque Ahmad Abdulrahman A. Alsayegh Fakhruddin Ali Ahmad Md Sayeed Akhtar Sirajudeen S. Alavudeen Farkad Bantun Shadma Wahab Awais Ahmed M. Ali Ehab Y. Elbendary António Raposo Nahla Kambal Mohamed H. Abdelrahman |
| author_facet | Md Faruque Ahmad Abdulrahman A. Alsayegh Fakhruddin Ali Ahmad Md Sayeed Akhtar Sirajudeen S. Alavudeen Farkad Bantun Shadma Wahab Awais Ahmed M. Ali Ehab Y. Elbendary António Raposo Nahla Kambal Mohamed H. Abdelrahman |
| author_sort | Md Faruque Ahmad |
| collection | DOAJ |
| description | Ganoderma lucidum is a versatile mushroom. Polysaccharides and triterpenoids are the major bioactive compounds and have been used as traditional medicinal mushrooms since ancient times. They are currently used as nutraceuticals and functional foods. G. lucidum extracts and their bioactive compounds have been used as an alternative to antioxidants and antimicrobial agents. Secondary metabolites with many medicinal properties make it a possible substitute that could be applied as immunomodulatory, anticancer, antimicrobial, anti-oxidant, anti-inflammatory, and anti-diabetic. The miraculous properties of secondary metabolites fascinate researchers for their development and production. Recent studies have paid close attention to the different physical, genetic, biochemical, and nutritional parameters that potentiate the production of secondary metabolites. This review is an effort to collect biologically active constituents from G. lucidum that reveal potential actions against diseases with the latest improvement in a novel technique to get maximum production of secondary metabolites. Studies are going ahead to determine the efficacy of numerous compounds and assess the valuable properties achieved by G. lucidum in favor of antimicrobial and antioxidant outcomes. |
| first_indexed | 2024-03-08T00:09:48Z |
| format | Article |
| id | doaj.art-09063b10271342d3bd4fab8344f03ed9 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T00:09:48Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-09063b10271342d3bd4fab8344f03ed92024-02-17T06:41:32ZengElsevierHeliyon2405-84402024-02-01103e25607Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolitesMd Faruque Ahmad0Abdulrahman A. Alsayegh1Fakhruddin Ali Ahmad2Md Sayeed Akhtar3Sirajudeen S. Alavudeen4Farkad Bantun5Shadma Wahab6Awais Ahmed7M. Ali8Ehab Y. Elbendary9António Raposo10Nahla Kambal11Mohamed H. Abdelrahman12Department of Clinical Nutrition, College of Applied Medical Science, Jazan University, Jazan, 45142, Saudi Arabia; Corresponding author.Department of Clinical Nutrition, College of Applied Medical Science, Jazan University, Jazan, 45142, Saudi ArabiaDepartment of Basic and Applied Science, School of Engineering and Science, G.D Goenka University, Gru Gram, 122103, Haryana, IndiaDepartment of Clinical Pharmacy, College of Pharmacy, King Khalid University, AlFara, Abha, 62223, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, King Khalid University, AlFara, Abha, 62223, Saudi ArabiaDepartment of Microbiology and Parasitology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, 62529, Saudi ArabiaDepartment of Management, Shri JJT University, Rajasthan, Post code; 333010, IndiaDepartment of Pharmacognosy, CBS College of Pharmacy & Technology (Pt. B. D. Sharma University of Health Sciences), Chandpur, Faridabad, Haryana, 121101, IndiaDepartment of Clinical Nutrition, College of Applied Medical Science, Jazan University, Jazan, 45142, Saudi ArabiaCBIOS (Research Center for Biosciences and Health Technologies), Universidade Lusófona de Humanidades Tecnologias, Campo Grande 376, 1749-024, Lisboa, PortugalDepartment of Clinical Nutrition, College of Applied Medical Science, Jazan University, Jazan, 45142, Saudi ArabiaCollege of Applied Medical Sciences, Medical Laboratory Sciences, Jazan University, Jazan, 45142, Saudi ArabiaGanoderma lucidum is a versatile mushroom. Polysaccharides and triterpenoids are the major bioactive compounds and have been used as traditional medicinal mushrooms since ancient times. They are currently used as nutraceuticals and functional foods. G. lucidum extracts and their bioactive compounds have been used as an alternative to antioxidants and antimicrobial agents. Secondary metabolites with many medicinal properties make it a possible substitute that could be applied as immunomodulatory, anticancer, antimicrobial, anti-oxidant, anti-inflammatory, and anti-diabetic. The miraculous properties of secondary metabolites fascinate researchers for their development and production. Recent studies have paid close attention to the different physical, genetic, biochemical, and nutritional parameters that potentiate the production of secondary metabolites. This review is an effort to collect biologically active constituents from G. lucidum that reveal potential actions against diseases with the latest improvement in a novel technique to get maximum production of secondary metabolites. Studies are going ahead to determine the efficacy of numerous compounds and assess the valuable properties achieved by G. lucidum in favor of antimicrobial and antioxidant outcomes.http://www.sciencedirect.com/science/article/pii/S2405844024016384AntimicrobialAntioxidantSecondary metabolitesTriterpenoids and polysaccharides |
| spellingShingle | Md Faruque Ahmad Abdulrahman A. Alsayegh Fakhruddin Ali Ahmad Md Sayeed Akhtar Sirajudeen S. Alavudeen Farkad Bantun Shadma Wahab Awais Ahmed M. Ali Ehab Y. Elbendary António Raposo Nahla Kambal Mohamed H. Abdelrahman Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites Heliyon Antimicrobial Antioxidant Secondary metabolites Triterpenoids and polysaccharides |
| title | Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites |
| title_full | Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites |
| title_fullStr | Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites |
| title_full_unstemmed | Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites |
| title_short | Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites |
| title_sort | ganoderma lucidum insight into antimicrobial and antioxidant properties with development of secondary metabolites |
| topic | Antimicrobial Antioxidant Secondary metabolites Triterpenoids and polysaccharides |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024016384 |
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