Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors
The vast majority of studies on T cell biology in tumor immunity have focused on peptide-reactive conventional T cells that are restricted to polymorphic major histocompatibility complex molecules. However, emerging evidence indicated that unconventional T cells, including γδ T cells, natural killer...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/14/3578 |
| _version_ | 1797527426167734272 |
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| author | Emilie Barsac Carolina de Amat Herbozo Loïc Gonzalez Thomas Baranek Thierry Mallevaey Christophe Paget |
| author_facet | Emilie Barsac Carolina de Amat Herbozo Loïc Gonzalez Thomas Baranek Thierry Mallevaey Christophe Paget |
| author_sort | Emilie Barsac |
| collection | DOAJ |
| description | The vast majority of studies on T cell biology in tumor immunity have focused on peptide-reactive conventional T cells that are restricted to polymorphic major histocompatibility complex molecules. However, emerging evidence indicated that unconventional T cells, including γδ T cells, natural killer T (NKT) cells and mucosal-associated invariant T (MAIT) cells are also involved in tumor immunity. Unconventional T cells span the innate–adaptive continuum and possess the unique ability to rapidly react to nonpeptide antigens via their conserved T cell receptors (TCRs) and/or to activating cytokines to orchestrate many aspects of the immune response. Since unconventional T cell lineages comprise discrete functional subsets, they can mediate both anti- and protumoral activities. Here, we review the current understanding of the functions and regulatory mechanisms of protumoral unconventional T cell subsets in the tumor environment. We also discuss the therapeutic potential of these deleterious subsets in solid cancers and why further feasibility studies are warranted. |
| first_indexed | 2024-03-10T09:43:40Z |
| format | Article |
| id | doaj.art-09077822afa74987b22bf1a4a4f3a3af |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:43:40Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-09077822afa74987b22bf1a4a4f3a3af2023-11-22T03:25:40ZengMDPI AGCancers2072-66942021-07-011314357810.3390/cancers13143578Regulation and Functions of Protumoral Unconventional T Cells in Solid TumorsEmilie Barsac0Carolina de Amat Herbozo1Loïc Gonzalez2Thomas Baranek3Thierry Mallevaey4Christophe Paget5Centre d’Étude des Pathologies Respiratoires, UMR1100, INSERM (Institut National de la Santé et de la Recherche Médicale), Faculté de Médecine, Université de Tours, 37012 Tours, FranceDepartment of Immunology, University of Toronto, Toronto, ON M5S 1A8, CanadaCentre d’Étude des Pathologies Respiratoires, UMR1100, INSERM (Institut National de la Santé et de la Recherche Médicale), Faculté de Médecine, Université de Tours, 37012 Tours, FranceCentre d’Étude des Pathologies Respiratoires, UMR1100, INSERM (Institut National de la Santé et de la Recherche Médicale), Faculté de Médecine, Université de Tours, 37012 Tours, FranceDepartment of Immunology, University of Toronto, Toronto, ON M5S 1A8, CanadaCentre d’Étude des Pathologies Respiratoires, UMR1100, INSERM (Institut National de la Santé et de la Recherche Médicale), Faculté de Médecine, Université de Tours, 37012 Tours, FranceThe vast majority of studies on T cell biology in tumor immunity have focused on peptide-reactive conventional T cells that are restricted to polymorphic major histocompatibility complex molecules. However, emerging evidence indicated that unconventional T cells, including γδ T cells, natural killer T (NKT) cells and mucosal-associated invariant T (MAIT) cells are also involved in tumor immunity. Unconventional T cells span the innate–adaptive continuum and possess the unique ability to rapidly react to nonpeptide antigens via their conserved T cell receptors (TCRs) and/or to activating cytokines to orchestrate many aspects of the immune response. Since unconventional T cell lineages comprise discrete functional subsets, they can mediate both anti- and protumoral activities. Here, we review the current understanding of the functions and regulatory mechanisms of protumoral unconventional T cell subsets in the tumor environment. We also discuss the therapeutic potential of these deleterious subsets in solid cancers and why further feasibility studies are warranted.https://www.mdpi.com/2072-6694/13/14/3578unconventional T cellsγδTNKTMAITimmunoregulationcytokines |
| spellingShingle | Emilie Barsac Carolina de Amat Herbozo Loïc Gonzalez Thomas Baranek Thierry Mallevaey Christophe Paget Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors Cancers unconventional T cells γδT NKT MAIT immunoregulation cytokines |
| title | Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors |
| title_full | Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors |
| title_fullStr | Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors |
| title_full_unstemmed | Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors |
| title_short | Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors |
| title_sort | regulation and functions of protumoral unconventional t cells in solid tumors |
| topic | unconventional T cells γδT NKT MAIT immunoregulation cytokines |
| url | https://www.mdpi.com/2072-6694/13/14/3578 |
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